Patents by Inventor Howard I. Pryor
Howard I. Pryor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10939989Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: November 1, 2017Date of Patent: March 9, 2021Assignees: The General Hospital Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 10327885Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: February 6, 2015Date of Patent: June 25, 2019Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Publication number: 20180256312Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: November 1, 2017Publication date: September 13, 2018Inventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Publication number: 20150366651Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: February 6, 2015Publication date: December 24, 2015Applicants: THE CHARLES STARK DRAPER LABORATORY, THE GENERAL HOSPITAL CORPORATIONInventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 8951302Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: October 9, 2009Date of Patent: February 10, 2015Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Howard I. Pryor, Ira Spool, David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 8591597Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: March 22, 2010Date of Patent: November 26, 2013Assignee: The General Hospital CorporationInventors: David M. Hoganson, Joseph P. Vacanti, Howard I. Pryor
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Publication number: 20110195056Abstract: The invention generally features methods for generating hepatocytes from a variety of pluripotent stem cells, including adipose mesenchymal stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.Type: ApplicationFiled: July 31, 2009Publication date: August 11, 2011Applicant: The General Hospital CorporationInventors: Howard I. Pryor, Joseph P. Vacanti, David H. Lum, Tim D. Ahfeldt, Chad Cowan
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Publication number: 20110129436Abstract: The present invention is directed to a method of preventing adhesions between two tissue surfaces. The method includes providing a film comprising a condensation polymer of glycerol and a diacid, wherein the film does not contain anti-inflammatory drugs and positioning the film between a first tissue surface and a second tissue surface under conditions effective to prevent adhesion between said first tissue surface and said second tissue surface.Type: ApplicationFiled: February 17, 2009Publication date: June 2, 2011Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Howard I. Pryor, II, Cathryn A. Sundback, Joseph P. Vacanti
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Publication number: 20110091930Abstract: A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid outlets in fluid communication with the assay well plates through conduits. Methods of using the system for cell culture and drug toxicity screening are also provided including coculturing cells such as hepatocytes, stem cells, fibroblasts and smooth muscle cells and selectively exposing cells to test compounds.Type: ApplicationFiled: February 13, 2009Publication date: April 21, 2011Applicant: The General Hospital CorporationInventors: Joseph P. Vacanti, Howard I. Pryor, Craig M. Neville, Ira Spool
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Publication number: 20100274353Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: March 22, 2010Publication date: October 28, 2010Applicant: The General Hospital CorporationInventors: Howard I. Pryor, David M. Hoganson, Joseph P. Vacanti
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Publication number: 20100234678Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: October 9, 2009Publication date: September 16, 2010Applicants: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Howard I. Pryor, Ira Spool, David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein