Patents by Inventor Howard J. Leonhardt

Howard J. Leonhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190030330
    Abstract: Described are a system and method that “reads” cancer tumors real time and custom delivers individualized bioelectric therapy to the patient. For example, the system reads a cancer tumor, and based upon this read, delivers to the subject “a confounding signal” to jam communication within that tumor. A cancer tumor may change its communication patterns and the therapy is designed to change with these patterns, attempting to always jam the relevant communication signaling pathway. The described system includes parameters not tied to communication jamming, which should also be customized to induce apoptosis to the cancer tumor. Such parameters include signals for starving a cancer tumor of blood supply and signals for changing the cancer tumor's surface proteins and/or charge so that the immune system attacks the cancer tumor.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 31, 2019
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20190022389
    Abstract: Described is a low voltage, pulsed electrical stimulation device for reducing inflammation in a subject, which can be useful in the treatment of concussions, traumatic brain injury, cancer, and so forth.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 24, 2019
    Inventor: Howard J. Leonhardt
  • Publication number: 20190022396
    Abstract: Described are a system and method that utilize bioelectric signaling to balance electrical potentials in a subject's body via neuro-hormonal circuit loops, to increase elasticity of the subject's arteries to promote protein release to dampen arterial blood pressure, and to change arterial electrical charges to reduce narrowing of the arteries. The described system is designed to localize and stimulate the fibers inside the vagus nerve without inadvertent stimulation of non-baroreceptive fibers causing side effects like bradycardia and bradypnea. The system also controls release of specific proteins known to lower blood pressures including tropoelastin (known to increase elasticity in the aorta and other peripheral blood vessels).
    Type: Application
    Filed: September 20, 2018
    Publication date: January 24, 2019
    Inventor: Howard J. Leonhardt
  • Publication number: 20190015661
    Abstract: Described is a skin regeneration therapy. The described therapy combines precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.
    Type: Application
    Filed: September 12, 2018
    Publication date: January 17, 2019
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20180064935
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 8, 2018
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20170274206
    Abstract: Described is a bioelectric stimulating device for reducing orthodontic treatment time (braces) with post-treatment stability enhancement. The device and associated methods provide a native sustainable optimal release of an increase in the quantity of the right cells and proteins over time and in the right sequence to optimize tooth movement with the braces by accelerating bone resorption at the leading edge of the tooth during movement. This acceleration phenomenon is responsible for being able to shorten orthodontic treatment time. Following the final alignment of the teeth, the same device can utilize the native response and accelerate the tooth/bone interface stability by targeting specific cells and proteins that are responsible for bone deposition (hardening) in order to shorten the retention phase, while greatly decreasing the chance of relapse (instability).
    Type: Application
    Filed: March 28, 2017
    Publication date: September 28, 2017
    Applicant: CalXStars Business Accelerator, Inc.
    Inventors: Howard J. Leonhardt, Jorge Genovese, John Joseph Marchetto
  • Publication number: 20170266371
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Applicant: CalXStars Business Accelerator, Inc.
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 8308708
    Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: November 13, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Howard J Leonhardt, Robert D. Lashinski
  • Patent number: 8133267
    Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: March 13, 2012
    Assignee: Medtronic Vascular, Inc.
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Publication number: 20100217383
    Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
    Type: Application
    Filed: March 1, 2010
    Publication date: August 26, 2010
    Applicant: Medtronic Vascular, Inc.
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Publication number: 20100137835
    Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
    Type: Application
    Filed: February 5, 2010
    Publication date: June 3, 2010
    Inventors: Howard J. Leonhardt, Robert D. Lashinski
  • Patent number: 7699885
    Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: April 20, 2010
    Assignee: Medtronic Vascular, Inc.
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Patent number: 7686799
    Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: March 30, 2010
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Howard J Leonhardt, Robert D Lashinski
  • Patent number: 7483749
    Abstract: The present invention provides a method for enhancing regeneration of the myocardium. The method comprises the steps of applying electrical stimulation to an injury site in the myocardium. The method can be used in combination with implantation of myogenic cells into the injury site. The electrical stimulation may be applied before or after the implantation.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: January 27, 2009
    Assignee: Bioheart, Inc.
    Inventors: Howard J. Leonhardt, Juan C. Chachques
  • Patent number: 7341062
    Abstract: The present invention provides a method for repairing damaged myocardium. The method comprises using a combination of cellular cardiomyoplasty and electrostimulation for myogenic predifferentiation of stem cells and to synchronize the contractions of the transplanted cells with the cardiac cells. The method comprises the steps of obtaining stem or myogenic cells from a donor, culturing and electrostimulating the isolated cells in vitro, and implanting the cells into the damaged myocardium.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: March 11, 2008
    Assignee: Bioheart, Inc.
    Inventors: Juan C. Chachques, Howard J. Leonhardt
  • Patent number: 6852116
    Abstract: A method for deploying an endoluminal prosthesis by introducing into a bifurcated vessel a sheath introducer having therein a bifurcated graft with a primary and contralateral limb. The contralateral limb being radially retained independent of the sheath introducer. The graft being positionable by an insertion catheter. When the graft is in position within the vessel, a retaining device about the contralateral limb is broken and the graft takes the shape of the vessel.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: February 8, 2005
    Assignee: World Medical Manufacturing Corporation
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Publication number: 20040236403
    Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
    Type: Application
    Filed: June 30, 2004
    Publication date: November 25, 2004
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Patent number: 6767358
    Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: July 27, 2004
    Assignee: World Medical Manufacturing Corporation
    Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
  • Patent number: 6690970
    Abstract: A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions. The implantation catheter has a central nerve cell injection needle connected to a syringe or the like via a cell injection tube, and two elongated lateral stabilizing needles. The catheter is inserted into a blood vessel in a patient's leg, arm, shoulder or the like, and advanced until the catheter's distal end is located above the malfunction area.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: February 10, 2004
    Inventors: Syde A. Taheri, Howard J. Leonhardt
  • Publication number: 20040010231
    Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
    Type: Application
    Filed: July 15, 2003
    Publication date: January 15, 2004
    Inventors: Howard J Leonhardt, Robert D Lashinski