Patents by Inventor Howard J. Leonhardt

Howard J. Leonhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220117719
    Abstract: Described is an intravascular device including a stent structure and at least one annular band. The stent structure may be sized for insertion into a blood vessel and configured to expand to contact the wall of a blood vessel after insertion therein. The annular band is configured to change in diameter in response to an applied electrical field. A method of maintaining and accelerating pulsatile blood flow includes positioning an annular band within a blood vessel, and causing the annular band to expand and contract in response to an electrical field.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 21, 2022
    Inventor: Howard J. Leonhardt
  • Publication number: 20220023623
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of sonic hedgehog (“Shh”), a useful protein, by tissues. Also described are methods of enhancing expression of sonic hedgehog in cells, particularly a method of stimulating the expression and/or release of Shh in a cell having a gene encoding Shh, wherein the method includes applying a bioelectric signal of less than 50 Hz (e.g., 5 Hz, 10 Hz, or 20 Hz) at a pulse width duration of, e.g., 1 ms, to the cell (e.g., directly, indirectly, or wirelessly), and wherein the amount of Shh expression enhanced by this bioelectric signal is greater than that seen with a prior art bioelectric muscle stimulation or bioelectric muscle contraction alone as may be determined by, e.g., by an analysis of the upregulation of mRNA level/GAPDH fold gene expression in the cell.
    Type: Application
    Filed: October 11, 2021
    Publication date: January 27, 2022
    Inventor: Howard J. Leonhardt
  • Publication number: 20210402184
    Abstract: Described is a low voltage, pulsed electrical stimulation device for upregulating expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Inventor: Howard J. Leonhardt
  • Patent number: 11185691
    Abstract: Described are a system and method that “reads” cancer tumors real time and custom delivers individualized bioelectric therapy to the patient. For example, the system reads a cancer tumor, and based upon this read, delivers to the subject “a confounding signal” to jam communication within that tumor. A cancer tumor may change its communication patterns and the therapy is designed to change with these patterns, attempting to always jam the relevant communication signaling pathway. The described system includes parameters not tied to communication jamming, which should also be customized to induce apoptosis to the cancer tumor. Such parameters include signals for starving a cancer tumor of blood supply and signals for changing the cancer tumor's surface proteins and/or charge so that the immune system attacks the cancer tumor.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: November 30, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 11167141
    Abstract: Described are a system and method that utilize bioelectric signaling to balance electrical potentials in a subject's body via neuro-hormonal circuit loops, to increase elasticity of the subject's arteries to promote protein release to dampen arterial blood pressure, and to change arterial electrical charges to reduce narrowing of the arteries. The described system is designed to localize and stimulate the fibers inside the vagus nerve without inadvertent stimulation of non-baroreceptive fibers causing side effects like bradycardia and bradypnea. The system also controls release of specific proteins known to lower blood pressures including tropoelastin (known to increase elasticity in the aorta and other peripheral blood vessels).
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: November 9, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventor: Howard J. Leonhardt
  • Publication number: 20210339018
    Abstract: A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 11110274
    Abstract: Described is a low voltage, pulsed electrical stimulation device for reducing inflammation in a subject, which can be useful in the treatment of concussions, traumatic brain injury, cancer, and so forth.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: September 7, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventor: Howard J. Leonhardt
  • Publication number: 20210236817
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Application
    Filed: March 29, 2021
    Publication date: August 5, 2021
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20210228870
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of Collagen Type XVII Alpha 1 chain (COL 17A1), a useful protein, by tissues. Also described are methods of COL17A1 in cells.
    Type: Application
    Filed: January 28, 2021
    Publication date: July 29, 2021
    Inventor: Howard J. Leonhardt
  • Patent number: 11052247
    Abstract: A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: July 6, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20210121681
    Abstract: A method of using a bioelectric stimulator for delivering an electrical signal to a subject's tissue, wherein the bioelectric stimulator utilizes the electrical signal to precisely control protein expression and/or release in the tissue on demand so as to increase milk production in a subject, the method including: delivering selected electrical signals to the subject so as to precisely control protein expressions and/or release to increase milk production in the subject.
    Type: Application
    Filed: April 1, 2019
    Publication date: April 29, 2021
    Inventors: Howard J. Leonhardt, Paul Norman, Jorge Genovese, Leslie Miller
  • Patent number: 10960206
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 30, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20210077687
    Abstract: A minimally invasive circulatory support platform that utilizes an aortic stent pump or pumps. The platform uses a low profile catheter-based techniques and provides temporary and chronic circulatory support depending on the needs of the patient. Further described is a wirelessly powered circulatory assist pump for providing chronic circulatory support for heart failure patients. The platform and system are relatively easy to place, have higher flow rates than existing systems, and provide improvements in the patient's renal function.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 18, 2021
    Inventor: Howard J. Leonhardt
  • Publication number: 20210008263
    Abstract: A minimally invasive circulatory support platform that utilizes an aortic stent pump or pumps. The platform uses a low profile catheter-based techniques and provides temporary and chronic circulatory support depending on the needs of the patient. Also described is a catheter-based temporary assist pump to treat patients with acute decompensated heart failure and provide circulatory support to subjects undergoing high risk percutaneous coronary intervention (“PCI”). Further described is a wirelessly powered circulatory assist pump for providing chronic circulatory support for heart failure patients. The platform and system are relatively easy to place, have higher flow rates than existing systems, and provide improvements in the patient's renal function.
    Type: Application
    Filed: March 20, 2019
    Publication date: January 14, 2021
    Inventor: Howard J. Leonhardt
  • Publication number: 20200330759
    Abstract: Described is a method of treating a subject diagnosed with cancer, breast cancer, bone cancer, lung cancer, osteoporosis, multiple myeloma, and a combination of any thereof by applying a bioelectric signal or signals that upregulate the expression of Osteoprotegerin (“OPG”) and thus beneficially effect the subject's OPG/RANKL/RANK pathway.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 22, 2020
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20200330753
    Abstract: Described is a bioelectric stimulating device for reducing orthodontic treatment time (braces or aligners) with post-treatment stability enhancement. The device and associated methods provide a native sustainable optimal upregulated expression and/or release of an increase in the quantity of the right cells and proteins over time and in the right sequence to optimize tooth movement with the braces or aligners by accelerating bone resorption at the leading edge of the tooth during movement. This acceleration phenomenon is responsible for being able to shorten orthodontic treatment time. Following the final alignment of the teeth, the same device can utilize the native response and accelerate the tooth/bone interface stability by targeting specific cells and proteins that are responsible for bone deposition (hardening) in order to shorten the retention phase, while greatly decreasing the chance of relapse (instability).
    Type: Application
    Filed: June 29, 2020
    Publication date: October 22, 2020
    Inventors: Howard J. Leonhardt, John Joseph Marchetto, Jorge Genovese, Alex Richardson
  • Publication number: 20200324106
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of sonic hedgehog (“Shh”), a useful protein, by tissues. Also described are methods of enhancing expression of sonic hedgehog in cells, particularly a method of stimulating the expression and/or release of Shh in a cell having a gene encoding Shh, wherein the method includes applying a bioelectric signal of less than 50 Hz (e.g., 5 Hz, 10 Hz, or 20 Hz) at a pulse width duration of, e.g., 1 ms, to the cell (e.g., directly, indirectly, or wirelessly), and wherein the amount of Shh expression enhanced by this bioelectric signal is greater than that seen with a prior art bioelectric muscle stimulation or bioelectric muscle contraction alone as may be determined by, e.g., by an analysis of the upregulation of mRNA level/GAPDH fold gene expression in the cell.
    Type: Application
    Filed: April 13, 2020
    Publication date: October 15, 2020
    Inventor: Howard J. Leonhardt
  • Publication number: 20200289826
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 17, 2020
    Inventor: Howard J. Leonhardt
  • Publication number: 20200289820
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells and treating a subject's kidneys.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 17, 2020
    Inventor: Howard J. Leonhardt
  • Publication number: 20200229831
    Abstract: Methods of heart valve decalcification may include mechanically removing calcium deposits on a heart valve, and removing debris from the mechanical decalcification via suction. The mechanical removal of the calcium deposits may be accomplished with a burr and/or an ultrasonic device. In some embodiments, mechanical removal of the calcium deposits may be accomplished with a handheld mechanical decalcification device comprising a bur extending from a hand piece. A catheter system for removing plaque deposits from a heart valve may include at least one mechanical decalcification device configured for cleaning the edges of heart valve leaflets, and at least one active aspiration device. The at least one mechanical decalcification device may comprise a bur and/or an ultrasonic device. The system may additionally include a deployable net apparatus configured to encompass at least a portion of a heart valve.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 23, 2020
    Inventors: Howard J. Leonhardt, Brett M. Burton, Kapil K. Sharma, Betty Vowles