Patents by Inventor Howard J. Schaeffer

Howard J. Schaeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5364516
    Abstract: Catalytic cracking catalysts/additives which comprise rare-earth, preferably lanthanum, oxide and/or oxychloride dispersed in an acid reacted metakaolin matrix. The catalysts/additives may be combined with zeolite-containing cracking catalysts to enhance catalytic activity/selectivity in the presence of metals (Ni and V).
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: November 15, 1994
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Ranjit Kumar, Ronald E. Ritter, Howard J. Schaeffer, III
  • Patent number: 5248642
    Abstract: Catalytic cracking catalysts/additives which comprise rare-earth, preferably lanthanum, oxide and/or oxychloride dispersed in an acid reacted metakaolin matrix. The catalysts/additives may be combined with zeolite-containing cracking catalysts to enhance catalytic activity/selectivity in the presence of metals (Ni and V).
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: September 28, 1993
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Ranjit Kumar, Ronald E. Ritter, Howard J. Schaeffer, III
  • Patent number: 4649140
    Abstract: The novel compound 6-deoxyacyclovir, which itself has antiviral activity against herpes viruses, is converted enzymatically to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxygenase.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: March 10, 1987
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4360522
    Abstract: 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.
    Type: Grant
    Filed: February 1, 1978
    Date of Patent: November 23, 1982
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4323573
    Abstract: Novel 2-amino substituted adenine compounds and their use as antiviral compounds are disclosed. In particular the compound 2-amino-9-(2-hydroxyethoxymethyl) adenine is particularly advantageous as an antiviral in that it has high oral absorption and that upon metabolism in mammals, it has the property of being converted to 9-(2-hydroxyethoxymethyl) guanine which is also a highly active antiviral.
    Type: Grant
    Filed: February 1, 1978
    Date of Patent: April 6, 1982
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4315920
    Abstract: Pharmaceutical preparations containing compounds of the formula ##STR1## where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: February 16, 1982
    Assignee: Burroughs Wellcome Co.
    Inventors: Howard J. Schaeffer, Paulo M. S. DeMiranda, Gertrude B. Elion, George H. Hitchings
  • Patent number: 4294831
    Abstract: 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.
    Type: Grant
    Filed: February 1, 1978
    Date of Patent: October 13, 1981
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4287188
    Abstract: 9-(2-Hydroxyethoxymethyl) (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharamceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-Hydroxyethoxymethyl)guanine and 2-amino-9-(2-hydroxyethoxymethyl) adenine are examples of especially active compounds of this invention. Also preferred because of its high oral absorption is the phosphate and especially the monophosphate of 9-(2-hydroxyethoxymethyl)guanine as well as pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: September 1, 1981
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4199574
    Abstract: 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulation containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: April 22, 1980
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer
  • Patent number: 4146715
    Abstract: Method of preparing 9-(2-hydroxyethoxymethyl)guanine which comprises preparing the compound ##STR1## wherein R and R.sup.1 are hydrogen, lower alkyl and phenyl and then hydrolyzing same. 9-(2-hydroxyethoxymethyl)guanine is useful as an antiviral.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: March 27, 1979
    Assignee: Burroughs Wellcome Co.
    Inventor: Howard J. Schaeffer