Abstract: The invention provides a composition and method for treatment of a subject suffering from liver disease comprising the oral administration of a slow release formulation of diltiazem and thiamine.

Abstract: The invention provides a composition and method for treatment of a subject suffering from liver disease comprising the oral administration of a slow release formulation of calcium channel blocker such as diltiazem and thiamine which is also an antioxidant which is relatively hydrophilic when compared with the calcium channel blocker.

Abstract: This invention relates to an oral composition for treatment or prevention of atherosclerosis comprising a low-dose aspirin and a low-dose of statin wherein the aspirin and statin are in a slow-release formulation. The invention also relates to a method of treatment or prevention of atherosclerosis using such a composition.

Abstract: A method of pharmaceutical therapy comprising administering at least one pharmaceutical, complementary medicine, or herbal product, orally at a dose sufficient to provide a clinically effective blood level in the portal vein and less than that required to provide a clinically effective blood level in the peripheral circulation to thereby provide a dose-delivery rate having a selective clinical effect in the liver.

Abstract: A predistortion power amplifier architecture has a power amplifier which receives an input via an amplitude modulator and a phase modulator. A sample of the output of the amplifier and a sample of the input to the amplifier are applied to an adaptive pre-distorter subsystem. The adaptive pre-distorter generates a gain correction signal which is applied to the amplitude modulator and a phase correction signal which is applied to the phase modulator. This serves to predistort the input signal to the power amplifier to compensate for non-linearities in the power amplifier. A switching arrangement alternately couples a sample of the input and output of the amplifier to a first and a second envelope detector. The outputs of the envelope detectors are applied to a difference amplifier. The switching arrangement has a chopping action on the signals which helps to offset imbalances in the characteristics of the two envelope detectors.

Abstract: A method of pharmaceutical therapy comprising administering at least one pharmaceutical, complementary medicine, or herbal product, orally at a dose sufficient to provide a clinically effective blood level in the portal vein and less than that required to provide a clinically effective blood level in the peripheral circulation to thereby provide a dose-delivery rate having a selective clinical effect in the liver.

Abstract: This invention relates to high power linear amplifiers. A high power linear amplifier is disclosed for communications such as CDMA communication systems. In accordance with the invention, there is provided a power amplifier comprising a power amplifier, a feedback circuit and a control element; wherein the architecture proposed uses an envelope detector to generate a baseband signal representing the amplitude envelope of the system input RF signal. This is digitised and used to generate phase and gain correction signals. The correction signals modulate the input signal to create a pre-distorted signal: which is applied to the power amplifier for amplification. The pre-distortion is such as to cancel the AM-AM and AM-PM distortion of the power amplifier thus resulting in an amplified output of improved spectral purity.