Abstract: Methods for treating a human having heptocellular carcinoma comprising administering to the human a therapeutically effective amount of Compound A: or a pharmaceutically acceptable salt thereof, wherein the human has a complete response or partial response.

Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.

Abstract: Provided is a screening method for compounds affecting fatty acid biosynthesis, the method comprising: providing a reaction mixture comprising: an acyl carrier moiety or enzymes and precursors sufficient to generate the acyl carrier moiety; a bacterial enzymatic pathway comprising at least two consecutively acting enzymes selected from the group consisting of: malonyl-CoA:ACP transacylase, beta-ketoacyl-ACP synthase III, NADPH dependent beta-ketoacyl-ACP reductase, beta-hydroxylacyl-ACP dehydrase and enoyl-ACP reductase; and substrates and cofactors required for the operation of the enzymes; contacting the reaction mixture with a prospective bioactive agent; conducting a high throughput measurement of the activity of the enzymatic pathway; and determining if the contacting altered the activity of the enzymatic pathway.

Abstract: The invention provides methods of modulating the activity of MurA polypeptides, particularly to treat disease.

Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.

Abstract: The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.

Abstract: The invention provides fabZ polypeptides and polynucleotides encoding fabZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabZ polypeptides to screen for antibacterial compounds.

Abstract: The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.

Abstract: The invention provides EF-Tu polypeptides and polynucleotides encoding EF-Tu polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing EF-Tu polypeptides to screen for antibacterial compounds.

Abstract: The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.

Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.

Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.

Abstract: The invention provides ratC polypeptides and polynucleotides encoding ratC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratC polypeptides to screen for antibacterial compounds.

Abstract: The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.

Abstract: The invention provides gidB polypeptides and polynucleotides encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.

Abstract: The invention provides topA polypeptides and polynucleotides encoding topA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing topA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.

Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.

Abstract: The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.

Abstract: The invention provides gidA1 polypeptides and DNA (RNA) encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.