Abstract: Provided herein are methods of producing and manufacturing iPSCs, such as iPSCs essentially free of exogeneous viral residuals, and RPE cells. Such methods may comprise cell seeding at low density (e.g., single-cell passaging) and/or culturing at elevated temperature.

Abstract: A nuclear reactor has an axially stratified fuel bed. The reactor features a reactor shell having a base, a top having an exhaust outlet, and an axis. The axially stratified fuel bed is within the reactor shell, and includes: a first zone configured to operate at a first temperature T1, the first zone comprising a plurality of first fuel particles, each first fuel particle comprising a first radioactive ceramic core and a first ceramic seal coating; and a second zone configured to operate at a second temperature T2, where T2>T1, the second zone comprising a plurality of second fuel particles, each second fuel particle comprising a second radioactive ceramic core and a second ceramic seal coating. A coolant fluid flow path carries a coolant fluid from the base of the reactor to the exhaust outlet, along a flow path passing sequentially through the first zone and the second zone.

Abstract: A nuclear reactor has an axially stratified fuel bed. The reactor features a reactor shell having a base, a top having an exhaust outlet, and an axis. The axially stratified fuel bed is within the reactor shell, and includes: a first zone configured to operate at a first temperature T1, the first zone comprising a plurality of first fuel particles, each first fuel particle comprising a first radioactive ceramic core and a first ceramic seal coating; and a second zone configured to operate at a second temperature T2, where T2>T1, the second zone comprising a plurality of second fuel particles, each second fuel particle comprising a second radioactive ceramic core and a second ceramic seal coating. A coolant fluid flow path carries a coolant fluid from the base of the reactor to the exhaust outlet, along a flow path passing sequentially through the first zone and the second zone.

Abstract: A method for monitoring and recording a process in a clean space and a system for implementing same are provided. The method involves providing an electronic process record to a user using at least one processor; monitoring, using at least one sensor, for an event associated with the electronic process record; detecting, using the at least one sensor, the event associated with the electronic process record; recording in at least one data storage, using the at least one processor, information associated with the detected event, the recorded information being associated with a record of the electronic process record in the at least one data storage; verifying, using the at least one processor in communication with the at least one data storage, the recorded information; and storing in the at least one data storage, using the at least one processor, an indication that the recorded information has been verified.

Abstract: A method for monitoring and recording a process in a clean space and a system for implementing same are provided. The method involves providing an electronic process record to a user using at least one processor; monitoring, using at least one sensor, for an event associated with the electronic process record; detecting, using the at least one sensor, the event associated with the electronic process record; recording in at least one data storage, using the at least one processor, information associated with the detected event, the recorded information being associated with a record of the electronic process record in the at least one data storage; verifying, using the at least one processor in communication with the at least one data storage, the recorded information; and storing in the at least one data storage, using the at least one processor, an indication that the recorded information has been verified.

Abstract: A method for monitoring and recording a process in a clean space and a system for implementing same are provided. The method involves providing an electronic process record to a user using at least one processor; monitoring, using at least one sensor, for an event associated with the electronic process record; detecting, using the at least one sensor, the event associated with the electronic process record; recording in at least one data storage, using the at least one processor, information associated with the detected event, the recorded information being associated with a record of the electronic process record in the at least one data storage; verifying, using the at least one processor in communication with the at least one data storage, the recorded information; and storing in the at least one data storage, using the at least one processor, an indication that the recorded information has been verified.

Abstract: A multi-inlet gas distributor for a fluidized bed chemical vapor deposition reactor that may include a distributor body having an inlet surface, an exit surface opposed to the inlet surface, and a side perimeter surface. The distributor body may also include multiple-inlets evenly spaced from each other, wherein the multiple-inlets penetrate the distributor body from the inlet surface to a first depth. The distributor body may additionally include cone-shaped apertures connecting to corresponding ones of the multiple-inlets at the first depth and extend from the first depth toward the exit surface. An apex may be formed on the exit surface at the intersection of the cone-shaped apertures.

Abstract: A method for monitoring and recording a process in a clean space and a system for implementing same are provided. The method involves providing an electronic process record to a user using at least one processor; monitoring, using at least one sensor, for an event associated with the electronic process record; detecting, using the at least one sensor, the event associated with the electronic process record; recording in at least one data storage, using the at least one processor, information associated with the detected event, the recorded information being associated with a record of the electronic process record in the at least one data storage; verifying, using the at least one processor in communication with the at least one data storage, the recorded information; and storing in the at least one data storage, using the at least one processor, an indication that the recorded information has been verified.

Abstract: A multi-inlet gas distributor for a fluidized bed chemical vapor deposition reactor that may include a distributor body having an inlet surface, an exit surface opposed to the inlet surface, and a side perimeter surface. The distributor body may also include multiple-inlets evenly spaced from each other, wherein the multiple-inlets penetrate the distributor body from the inlet surface to a first depth. The distributor body may additionally include cone-shaped apertures connecting to corresponding ones of the multiple-inlets at the first depth and extend from the first depth toward the exit surface. An apex may be formed on the exit surface at the intersection of the cone-shaped apertures.