Patents by Inventor Howard L. Elford

Howard L. Elford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating or preventing neuroinflammation or autoimmune diseases
    Publication number: 20170100352
    Abstract: Disclosed herein are ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.
    Type: Application
    Filed: December 21, 2016
    Publication date: April 13, 2017
    Inventor: Howard L. Elford
  • Methods for treating or preventing neuroinflammation or autoimmune diseases
    Patent number: 9526707
    Abstract: Disclosed herein are ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: December 27, 2016
    Inventor: Howard L. Elford
  • Methods for treating or preventing restenosis and other vascular proliferative disorders
    Patent number: 8932617
    Abstract: Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: January 13, 2015
    Inventors: Howard L. Elford, Arturo J. Cardounel
  • Methods for Treating or Preventing Restenosis and Other Vascular Proliferative Disorders
    Publication number: 20120329870
    Abstract: Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders.
    Type: Application
    Filed: September 16, 2011
    Publication date: December 27, 2012
    Inventors: Howard L. Elford, Arturo J. Cardounel
  • Methods for treating or preventing restenosis and other vascular proliferative disorders
    Patent number: 8029815
    Abstract: Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: October 4, 2011
    Inventors: Howard L. Elford, Arturo J. Cardounel
  • Methods for treating or preventing neuroinflammation or autoimmune diseases
    Publication number: 20090047250
    Abstract: Disclosed herein are ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.
    Type: Application
    Filed: August 13, 2008
    Publication date: February 19, 2009
    Inventor: Howard L. Elford
  • Therapeutic process for inhibiting NF-?B
    Patent number: 6924308
    Abstract: A therapeutic process is provided for the inhibition of NF-?B in mammals in whose cells NF-?B has been activated by an agency external to said cell.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: August 2, 2005
    Inventor: Howard L. Elford
  • Method of treating viral diseases
    Patent number: 6248782
    Abstract: A therapeutic process for treating disease in mammals caused by retroviruses in which the infected mammal is treated with a ribonucleotide reductase inhibitor such as a polyhydroxy benzoic, mandelic or phenylacetic acid derivative, such as N,3,4-trihydroxybenzamide, a hlydroxyurea, a thiosemicarbazone or other ribonucleotide reductase inhibitor. The polyhydroxybenzoic acid derivatives are also useful in the treatment of diseases in mammals caused by DNA viruses.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: June 19, 2001
    Inventors: Howard L. Elford, Bartholomeus van't Riet
  • Method of treating hemoglobinopathies
    Patent number: 5366996
    Abstract: A therapeutic process for treating anemias in primates, including man, particularly those anemias of genetic origin including sickle-cell anemia, which comprises administering to an anemic primate an amount of a polyhydroxy benzoic, mandelic or phenylacetic acid derivative as specified at a dose level sufficient to increase fetal hemoglobin.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: November 22, 1994
    Inventors: Howard L. Elford, Bartholomeus van't Riet
  • Therapeutic process for the treatment of septic shock
    Patent number: 5350770
    Abstract: A therapeutic process for treating septic shock comprising the administration of a polyhydroxy-substituted benzamide or phenylacetamide derivative to a human suffering from, or in danger of contracting, septic shock.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: September 27, 1994
    Inventors: Howard L. Elford, Bartholomeus van't Riet
  • Polyhydroxybenzoic acid derivatives
    Patent number: 5183828
    Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: February 2, 1993
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Polyhydroxybenzoic acid derivatives
    Patent number: 4942253
    Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: July 17, 1990
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Polyhydroxybenzoic acid derivatives
    Patent number: 4623659
    Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: November 18, 1986
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors
    Patent number: 4448730
    Abstract: Di, tri and tetrahydroxybenzohydroxamic acids, amides and the corresponding di, tri and tetrahydroxy substituted phenylalkanohydroxamic acids, amides and phenyl esters, ribonucleotide reductase inhibitors.
    Type: Grant
    Filed: April 20, 1982
    Date of Patent: May 15, 1984
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors
    Patent number: 4394389
    Abstract: Di and trihydroxybenzohydroxamic acids, amides, alkyl substituted amides and phenyl esters, ribonucleotide reductase inhibitors.
    Type: Grant
    Filed: March 24, 1981
    Date of Patent: July 19, 1983
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Hydroxy benzohydroxamic acids and benzamides
    Patent number: 4263322
    Abstract: Di or trihydroxybenzohydroxamic acids or N-substituted benzamides, inhibitors or ribonucleotide reductase.
    Type: Grant
    Filed: March 1, 1979
    Date of Patent: April 21, 1981
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler