Patents by Inventor Howard Norman Ernest Stevens
Howard Norman Ernest Stevens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11452696Abstract: A method for making a controlled release material, comprising the steps of: — (a) forming granules comprising one or more wax and one or more disintegrant; (b) spheronisation of the granules and (c) compaction of the spheronised granules of step so as to form the controlled release material. The invention also relates to a tablet and delayed and sustained release material made according to the method.Type: GrantFiled: November 16, 2015Date of Patent: September 27, 2022Assignee: DRUG DELIVERY INTERNATIONAL LTD.Inventors: Howard Norman Ernest Stevens, Alexander Balfour Mullen, Vivekanand Bhardwaj, Fiona Jane MacDougall, David Smith
-
Patent number: 10675247Abstract: A press coated tablet for delayed release of an active ingredient comprising: (a) a core comprising one or more active ingredients, and; (b) an erodible delayed release barrier surrounding the core and comprising a wax and two or more grades of L-HPC, wherein the wax and L-HPC are provided in a weight ratio of wax to L-HPC of from 30%:70% to 70%:30%. The invention also relates to a method of making the press coated tablet.Type: GrantFiled: November 16, 2015Date of Patent: June 9, 2020Assignee: Drug Delivery International Ltd.Inventors: Howard Norman Ernest Stevens, Alexander Balfour Mullen, David Smith, Fiona Jane Macdougall, Vivekanand Bhardwaj
-
Patent number: 10646448Abstract: A method of forming an erodible sustained release tablet comprising the steps of:—a. mixing one or more therapeutic agents, one or more disintegrant and one or more molten wax, whilst retaining the wax in molten form; b. solidifying and granulating the mixture; c. forming a tablet by compression of the granules. The invention also relates to a sustained release tablet made according to the method.Type: GrantFiled: November 16, 2015Date of Patent: May 12, 2020Assignee: Drug Delivery International Ltd.Inventors: Howard Norman Ernest Stevens, Alexander Balfour Mullen, Fiona Jane MacDougall, Claire Helen Ordoyno
-
Publication number: 20180055773Abstract: A method for making a controlled release material, comprising the steps of: — (a) forming granules comprising one or more wax and one or more disintegrant; (b) spheronisation of the granules and (c) compaction of the spheronised granules of step so as to form the controlled release material. The invention also relates to a tablet and delayed and sustained release material made according to the method.Type: ApplicationFiled: November 16, 2015Publication date: March 1, 2018Applicant: Drug Delivery International Ltd.Inventors: Howard Norman Ernest STEVENS, Alexander Balfour MULLEN, Vivekanand BHARDWAJ, Fiona Jane MACDOUGALL, David SMITH
-
Publication number: 20180008542Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.Type: ApplicationFiled: June 2, 2017Publication date: January 11, 2018Inventors: Barry Douglas Moore, Marie Claire Parker, Johann Partridge, Jan Vos, Michaela Maria Kreiner, Howard Norman Ernest Stevens, Maria Victoria Flores, Alistair Ross
-
Publication number: 20170333355Abstract: A press coated tablet for delayed release of an active ingredient comprising: (a) a core comprising one or more active ingredients, and; (b) an erodible delayed release barrier surrounding the core and comprising a wax and two or more grades of L-HPC, wherein the wax and L-HPC are provided in a weight ratio of wax to L-HPC of from 30%:70% to 70%:30%. The invention also relates to a method of making the press coated tablet.Type: ApplicationFiled: November 16, 2015Publication date: November 23, 2017Inventors: Howard Norman Ernest Stevens, Alexander Balfour Mullen, David Smith, Fiona Jane Macdougall, Vivekanand Bhardwaj
-
Publication number: 20170258731Abstract: A method of forming an erodible sustained release tablet comprising the steps of:—a. mixing one or more therapeutic agents, one or more disintegrant and one or more molten wax, whilst retaining the wax in molten form; b. solidifying and granulating the mixture; c. forming a tablet by compression of the granules. The invention also relates to a sustained release tablet made according to the method.Type: ApplicationFiled: November 16, 2015Publication date: September 14, 2017Inventors: Howard Norman Ernest STEVENS, Alexander Balfour MULLEN, Fiona Jane MACDOUGALL, Claire Helen ORDOYNO
-
Publication number: 20170014345Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.Type: ApplicationFiled: December 22, 2015Publication date: January 19, 2017Inventors: Barry Douglas Moore, Marie Claire Parker, Johann Partridge, Jan Vos, Michaela Maria Kreiner, Howard Norman Ernest Stevens, Maria Victoria Flores, Alistair Ross
-
Patent number: 7014869Abstract: The present invention relates to protein-coated micro-crystals and their method of preparation. The protein-coated micro-crystals may find particular application in preparing enzymes for use as biocatalysts; preparation of therapeutic proteins for use in pharmaceutical formulations; production of cleansing agents comprising enzymes; production of paints, varnishes, coatings, films and the like comprising proteins which impart protective and/or antifouling properties; production of films, polymers, inks, coatings, electrodes and/or optical materials comprising proteins for diagnostic kits and/or biosensor applications; use of proteins for studies of molecular recognition, molecular binding and inhibitor binding in non-aqueous media; and preparation of protein based food additives.Type: GrantFiled: November 13, 2001Date of Patent: March 21, 2006Assignee: University of StrathclydeInventors: Barry Douglas Moore, Marie Claire Parker, Peter James Halling, Johann Partridge, Howard Norman Ernest Stevens
-
Publication number: 20030099693Abstract: The present invention concerns a wafer composition comprising: a polymer substrate; a surfactant; and water; characterised in that the wafer further comprises stable, i.e. stable of size and form, crystalline particles of a pharmaceutically active wound healing agent.Type: ApplicationFiled: October 30, 2002Publication date: May 29, 2003Inventors: Anthony David Auffret, Gillian Margaret Eccleston, Michael John Humphrey, Kerr Hugh Matthews, Howard Norman Ernest Stevens
-
Patent number: 5897874Abstract: A delivery device for delivering an active substance to a patient at a predetermined time after administration comprises a male hydrogel plug engaged in the neck of a female body. An expandable excipient such as a hydrogel powder or a pharmaceutical disintegrant in powder, slug or tablet form is provided beneath the active substance. In contact with an aqueous medium, the excipient absorbs water and swells such as to rapidly expel the active substance and effectively deliver it from the device.Type: GrantFiled: September 20, 1996Date of Patent: April 27, 1999Assignee: R. P. Scherer CorporationInventors: Howard Norman Ernest Stevens, Abdul Rashid, Massoud Bakhshaee, Julie Stephanie Binns, Christopher Jon Miller
-
Patent number: 5770224Abstract: A controlled release capsule comprises a male plug (2) formed of a water swellable hydrogel which is engaged within a neck portion (4) of a female body (6). The capsule contains a pharmaceutically active material. In contact with an aqueous medium, such as in the gastrointestinal tract, the hydrogel plug swells and becomes disengaged from the body, thereby releasing the active material. In order to facilitate insertion of the male plug into the neck of the body, the body has a flared mouth portion (14) which is wider than the neck. The neck itself may be wider or narrower than the remainder of the body. A water-soluble cap (8) has detentes (18) which clip over the flared mouth portion so as to lock the cap thereto.Type: GrantFiled: June 26, 1995Date of Patent: June 23, 1998Assignee: R. P. Scherer CorporationInventors: Abdul Rashid, Howard Norman Ernest Stevens, Massoud Bakhshaee, James Robertson Miller Kelso, Mark Hegarty, James Leonard Mackie
-
Patent number: 5750143Abstract: A controlled release capsule comprises a male plug (2) formed of a water-swellable hydrogel which is engaged with a neck portion (4) of a female body (6). The capsule is intended to deliver two dosages of pharmaceutically active material at different times. A water soluble cap (8) is fitted over mouth (14) of the body, and defines a first volume (9) containing a first unit dosage (10). A second unit dosage (12) is contained within a second volume (11) defined by the plug and the female body. When the capsule is swallowed by a patient, the cap dissolves quickly in the aqueous medium within the gastro-intestinal tract and releases the first dosage. The aqueous medium then comes into contact with the hydrogel plug which swells and becomes disengaged from the body, usually in the intestine, thereby releasing the second dosage a predetermined time after the first dosage.Type: GrantFiled: June 27, 1995Date of Patent: May 12, 1998Assignee: R.P. Scherer CorporationInventors: Abdul Rashid, Howard Norman Ernest Stevens, Julie Stephanie Binns, James Leonard Mackie