Patents by Inventor Howard O. Nornes

Howard O. Nornes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of stable integration of DNA into neurons
    Patent number: 6555369
    Abstract: The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene along with the DNA encoding PCNA and RFC causes stable integration of the functional gene.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: April 29, 2003
    Assignee: Spinal Cord Society
    Inventors: Toomas Neuman, Howard O. Nornes
  • Method for inducing DNA synthesis in neurons
    Publication number: 20030027779
    Abstract: A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector.
    Type: Application
    Filed: January 25, 2002
    Publication date: February 6, 2003
    Applicant: Spinal Cord Society
    Inventors: Toomas Neuman, Kikuo Suda, Howard O. Nornes
  • Method for inducing DNA synthesis in neurons
    Patent number: 6372721
    Abstract: A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: April 16, 2002
    Assignee: Spinal Cord society
    Inventors: Toomas Neuman, Kikuo Suda, Howard O. Nornes
  • Method of stable integration of DNA into neurons
    Publication number: 20020031832
    Abstract: The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene along with the DNA encoding PCNA and RFC causes stable integration of the functional gene.
    Type: Application
    Filed: June 21, 2001
    Publication date: March 14, 2002
    Applicant: Spinal Cord Society
    Inventors: Toomas Neuman, Howard O. Nornes
  • Method of stable integration of DNA into neurons
    Patent number: 6268174
    Abstract: The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene along with the DNA encoding PCNA and RFC causes stable integration of the functional gene.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: July 31, 2001
    Assignee: Spinal Cord Society
    Inventors: Toomas Neuman, Howard O. Nornes
  • Method for inducing DNA synthesis in neurons
    Patent number: 6087171
    Abstract: A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: July 11, 2000
    Assignee: Spinal Cord Society
    Inventors: Toomas Neuman, Kikuo Suda, Howard O. Nornes
  • Method for upregulation of TRKB and TRKC receptors in central nervous system neurons
    Patent number: 5880153
    Abstract: The present invention provides compositions and methods for inducing expression of neurotrophic factor receptors trkB and trkC in neurons. The compositions include a material that activates a nuclear hormone receptor, a material that activates the second messenger response system, and a material that elevates Ca.sup.2+.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 9, 1999
    Assignee: Spinal Cord Society
    Inventors: Toomas Neuman, Henry Connor, Howard O. Nornes