Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.

Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.

Abstract: A system for illuminating an eye useful for tracking movement of an eye during vision correction treatments includes a generally arcuate main body having. The main body is constructed and arranged to be mounted in spaced relation to an eye to be tracked. An infrared light source is carried by the main body on at least a significant portion of its inner circumferential surface to direct infrared light toward the eye being treated at an angle from about 20 to 45 degrees with respect to an iris base plane of the eye being tracked.

Abstract: A system for illuminating an eye useful for tracking movement of an eye during vision correction treatments includes a generally arcuate main body having. The main body is constructed and arranged to be mounted in spaced relation to an eye to be tracked. An infrared light source is carried by the main body on at least a significant portion of its inner circumferential surface to direct infrared light toward the eye being treated at an angle from about 20 to 45 degrees with respect to an iris base plane of the eye being tracked.

Abstract: A system for illuminating an eye useful for tracking movement of an eye during vision correction treatments includes a generally arcuate main body having. The main body is constructed and arranged to be mounted in spaced relation to an eye to be tracked. An infrared light source is carried by the main body on at least a significant portion of its inner circumferential surface to direct infrared light toward the eye being treated at an angle from about 20 to 45 degrees with respect to an iris base plane of the eye being tracked.

Abstract: A system for illuminating an eye useful for tracking movement of an eye during vision correction treatments includes a generally arcuate main body having. The main body is constructed and arranged to be mounted in spaced relation to an eye to be tracked. An infrared light source is carried by the main body on at least a significant portion of its inner circumferential surface to direct infrared light toward the eye being treated at an angle from about 20 to 45 degrees with respect to an iris base plane of the eye being tracked.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliance. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or by means of a volume of known characteristics. The detected pressures and volume of air removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. Also, systolic and pulse pressures are determined using only these determined values.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliance. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or using a volume of known characteristics. The detected pressures and volume of air removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. A display of these characteristics as a function of pre and post anesthetic administration is particularly useful to the anesthesiologist and surgeon.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliance. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or by means of a volume of know characteristics. The detected pressures and volume of air removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. Also, systolic and pulse pressures are determined using only these determined values.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliance. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or by means of a volume of know characteristics. The detected pressures and volume of air, removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. A display of these characteristics as a function of pre and post anesthetic administration is particularly useful to the anesthesiologist and surgeon.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliance. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or by means of a volume of know characteristics. The detected pressures and volume of air removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. A display of these characteristics as a function of pre and post anesthetic administration is particularly useful to the anesthesiologist and surgeon.

Abstract: A method and apparatus are described for determining characteristics of peripheral arterial volume and compliane. A blood pressure cuff is inflated and deflated around a limb of the body and pressure measurements are taken. The volume of air removed from the cuff is determined in a quantifiable manner, such as by expelling air through an orifice of known characteristics or by means of a volume of know characteristics. The detected pressures and volume of air removed are used to compute oscillation volume, which in turn is used to display arterial capacity and compliance as a function of transmural pressure and time. Arterial capacity may be displayed in terms of arterial radius, arterial cross-sectional area, or arterial volume. A display of these characteristics as a function of pre and post anesthetic administration is particularly useful to the anesthesiologist and surgeon.

Abstract: A pressure cuff on the patient is inflated to a predetermined pressure above systolic, and then is deflated incrementally. At each decrement, oscillatory complexes are detected, and respective peaks are compared and evaluated as "true" complexes if they are within certain size matching criteria. After such "true" complexes are identified at a predetermined number of levels (e.g. 2 or 3), only a single complex is investigated at subsequent levels, provided specified size and timing criteria are met.

Abstract: An esophageal cardiac pulse probe includes a lumen for insertion into the esophagus, the end of the lumen preferably being closed by a flexible diaphragm. Pressure variations imparted to the fluid within the lumen in response to sounds from the heart and the lungs are transmitted to an electrical transducer which produces an electrical signal proportional to the time-varying frequency and intensity of the pressure variations. This signal is selectively filtered to effectively eliminate signal components due to respiratory noise and audible heart sounds and the resulting signal is fed to an appropriate visual display apparatus. Direct acoustic cardiac sound monitoring is also achievable with an earpiece connected to the lumen. Several probe geometries and a method of cardiac pulse waveform monitoring are also disclosed.

Abstract: An esophageal cardiac pulse probe includes a lumen for insertion into the esophagus, the end of the lumen preferably being closed by a flexible diaphragm. Pressure variations imparted to the fluid within the lumen in response to sounds from the heart and the lungs are transmitted to an electrical transducer which produces an electrical signal proportional to the time-varying frequency and intensity of the pressure variations. This signal is selectively filtered to effectively eliminate signal components due to respiratory noise and audible heart sounds and the resulting signal is fed to an appropriate visual display apparatus. Direct acoustic cardiac sound monitoring is also achievable with an earpiece connected to the lumen. Several probe geometries and a method of cardiac pulse waveform monitoring are also disclosed.