Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: An improved mechanism for processing client requests is disclosed. The first time a client request for a particular resource is received by a server, it is processed by stepping through a configuration file, and selectively executing directives specified in the configuration file. As the request is processed, a list of executed directives is compiled. This list of directives is stored for future reference. The next time a request for that same resource is received, the configuration file is not consulted. Instead, the stored list of directives is accessed and used to process the request. More specifically, all of the directives on the list are executed to process the request. Processing the subsequent request in this way eliminates much of the overhead associated with request processing. There is no need to open or to step through the configuration file, and there is no need to step through the directives themselves.

Abstract: Invented is a method of treating cardiovascular disease by employing a steriod 5-alpha-reductase inhibiting compound.