Patents by Inventor Howard R. Clarke

Howard R. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED RECOMBINANT PROTEIN EXPRESSION USING A HYBRID CHEF1 PROMOTER
    Publication number: 20210340560
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Application
    Filed: January 6, 2021
    Publication date: November 4, 2021
    Inventor: Howard R. Clarke
  • RECOMBINANT PROTEIN EXPRESSION USING A HYBRID CHEF1 PROMOTER
    Publication number: 20190071691
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Application
    Filed: March 29, 2018
    Publication date: March 7, 2019
    Inventor: Howard R. Clarke
  • Recombinant protein expression using a hybrid CHEF1 promoter
    Patent number: 9957525
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 1, 2018
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • RECOMBINANT PROTEIN EXPRESSION USING A HYBRID CHEF1 PROMOTER
    Publication number: 20160177335
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 23, 2016
    Inventor: Howard R. Clarke
  • Recombinant protein expression using a hybrid CHEF1 promoter
    Patent number: 9297024
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: March 29, 2016
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • Methods for improving recombinant protein expression
    Patent number: 9212367
    Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: December 15, 2015
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • RECOMBINANT PROTEIN EXPRESSION USING A HYBRID CHEF1 PROMOTER
    Publication number: 20140273208
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • Methods for Improving Recombinant Protein Expression
    Publication number: 20120214203
    Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.
    Type: Application
    Filed: August 6, 2010
    Publication date: August 23, 2012
    Applicant: CMC ICOS BIOLOGICS ,INC.
    Inventor: Howard R. Clarke