Patents by Inventor Howard Robert Marshall

Howard Robert Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indoles as modulators of nicotinic acetylcholine receptor subtype alpha-7
    Patent number: 8377941
    Abstract: The present invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 19, 2013
    Assignee: Proximagen Limited
    Inventors: Kevin Dinnell, Andrew P Lightfoot, Howard Robert Marshall
  • Indole modulators of the alpha 7 nicotinic acetylcholine receptor
    Patent number: 8283365
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: October 9, 2012
    Assignee: Proximagen Limited
    Inventors: Kevin Dinnell, Andrew P Lightfoot, Howard Robert Marshall
  • INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
    Publication number: 20110034515
    Abstract: This invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
    Type: Application
    Filed: April 16, 2009
    Publication date: February 10, 2011
    Inventors: Kevin Dinnell, Andrew P. Lightfoot, Howard Robert Marshall
  • INDOLES AS MODULATORS OF NICOTICIC ACETYLCHOLINE RECEPTOR SUBTYPE ALPHA-7
    Publication number: 20110028486
    Abstract: The present invention relates to modulation of the ?7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-5-(trifluoromethyl)-2-pyrimidinecarboxamide.
    Type: Application
    Filed: April 16, 2009
    Publication date: February 3, 2011
    Inventors: Kevin Dinnell, Andrew P. Lightfoot, Howard Robert Marshall
  • GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
    Publication number: 20110009440
    Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R1, R2, R6, R7, R8, R9 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises pharmaceutical formulations comprising these compounds and combinations of these compounds and one or more other therapeutic agents.
    Type: Application
    Filed: January 30, 2008
    Publication date: January 13, 2011
    Inventor: Howard Robert Marshall
  • OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS
    Publication number: 20100137428
    Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: June 3, 2010
    Inventors: Andrea Bozzoli, Clive Leslie Branch, Jacqueline Anne MacRitchie, Howard Robert Marshall, Roderick Alan Porter, Simone Spada
  • GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders
    Publication number: 20100105713
    Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R6, R7, R9, R10, R11, X, n, p, Ar and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
    Type: Application
    Filed: January 30, 2008
    Publication date: April 29, 2010
    Applicants: GLAXO GROUP LIMITED, UNIVERSITY OF NOTTINGHAM
    Inventors: Nadia Mamoona Ahmad, Daniele Andereotti, Justine Yeun Quai Lai, Howard Robert Marshall, David John Nash, Roderick Alan Porter
  • GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders
    Publication number: 20090325993
    Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, X, n, p and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
    Type: Application
    Filed: January 30, 2008
    Publication date: December 31, 2009
    Inventors: Nadia Mamoona Ahmad, Justine Yeun Quai Lai, Howard Robert Marshall, David John Nash, Roderick Alan Porter
  • N-Phenyl-2-0X0-1,4-Diazaspiro [4.5] Dec-3-EN-1-YL Acetamide Derivatives And Their Use As Glycine Transporter Inhibitors
    Publication number: 20090326027
    Abstract: Compounds of formula (I) and salts and solvates are provided. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: March 14, 2007
    Publication date: December 31, 2009
    Inventors: Steven Coulton, Howard Robert Marshall, David John Nash, Roderick Alan Porter
  • 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES
    Publication number: 20090286828
    Abstract: The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: November 19, 2009
    Inventors: Andrea Bozzoli, Clive Leslie Branch, Jacqueline Anne Macritchie, Howard Robert Marshall, Roderick Alan Porter, Simone Spada
  • GLYCINE TRANSPORT INHIBITORS
    Publication number: 20090270510
    Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: October 29, 2009
    Applicant: GLAXO GROUP LIMITED
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Martin Leonard Gilpin, Andrew Jonathan Harris, Justine Yeun Quai Lai, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simone Spada, Kevin Michael Thewlis, Simon Edward Ward
  • Compounds Which Inhibit the Glycine Transporter and Uses Thereof
    Publication number: 20090062360
    Abstract: Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 to R8 and n are defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: March 14, 2007
    Publication date: March 5, 2009
    Inventors: Steven Coulton, Howard Robert Marshall, David John Nash, Roderick Alan Porter
  • Glycine Transport Inhibitors
    Publication number: 20080287547
    Abstract: The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: November 20, 2008
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Martin Leonard Gilpin, Andrew Jonathan Harris, Albert Andrzej Jaxa-Chamiec, Justine Yeun Quai Lai, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simone Spada, Kevin Michael Thewlis, Simon Edward Ward
  • Acylated Piperidines as Glycine Transporter Inhibitors
    Publication number: 20080255144
    Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
    Type: Application
    Filed: March 9, 2006
    Publication date: October 16, 2008
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Anthony William Dean, Paul Martin Doyle, Brian Evans, Martin Leonard Gilpin, Sharon Lisa Gough, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simon Edward Ward