Abstract: A method of treating a chemical dependency disorder, an abuse syndrome or a combination thereof in a mammal in need thereof, which entails administering, to a mammal in need thereof, an amount of a .beta.-carboline alkaloid, hydrolyzable derivative thereof or pharmaceutically-acceptable salt thereof effective to treat said chemical dependency disorder, abuse syndrome or a combination thereof in the mammal.

Abstract: The administration to a poly-drug addict of ibogaine, ibogaine, tabernanthine, alkaloids in the family of apocynaceae, or their non-toxic salts have been discovered to interrupt the physiological and psychological aspects of poly-drug dependency (heroin, cocaine, alcohol, nicotine, caffeine, amphetamine, desoxyephedrine or methadone in combinations thereof). A single treatment or series of treatments may be effective for one to eighteen months or longer. Treatment consists of the oral or rectal administration of ibogaine, ibogamine, tabernanthine or their salts or derivatives in dosage ranges of 1 mg/kg to 60 mg/kg.

Abstract: The administration to a nicotine or tobacco addict of ibogaine, ibogamine or tabernanthine or non-toxic salts of those alkaloids, of the family apocynaceae, has been discovered to interrupt the physiological and psychological aspects of nicotine or tobacco dependency. A single treatment or series of treatments may be effective for one to eighteen months or longer. Treatment consists of the oral, rectal infusion or suppository administration of ibogaine, ibogamine, tabernanthine or their salts in dosage ranges of 1 mg/kg to 60 mg/kg.

Abstract: The administration to an alcohol dependent of ibogaine, ibogaine HCl or other non-toxic salts of ibogaine, an alkaloid of the family apocynaceae, has been discovered to unexpectedly diminish the physiological and psychological aspect of the alcohol dependency syndrome. A single treatment will be effective for about 6 months. The treatments consisted of the oral administration of ibogaine or its salts in dosage ranges of 4 mg/kg to 25 mg/kg. The minimum effective dose was 400 mgs. and dosage increases above 1200 mgs. were found to be for the most part unnecessary.

Abstract: The administration to a cocaine or amphetamine abuser of ibogaine, ibogaine HCl or other non toxic salts of ibogaine, an alkaloid of the family apocynaceae, has been discovered to unexpectedly interrupt the physiological and psychological aspect of the cocaine and/or amphetamine abuse syndrome. A single treatment was effective for about 6 months, and a series of 4 treatments was effective for approximately 3 years. The treatments consisted of the oral administration of ibogaine or its salts in dosage ranges of 6 mg/kg to 19 mg/kg. The minimum effective dose was 400 mgs and dosage increases above 1000 mgs were found to be unnecessary. Treatments were effective in 100% of the cases.

Abstract: The administration to a heroin addict of ibogaine, ibogaine HCl or other non toxic salts of ibogaine, an alkaloid of the family apocynaceae, has been discovered to unexpectedly interrupt the physiological and psychological aspects of the opiate addiction syndrome. A single treatment was effective for about 6 months, and a series of 4 treatments was effective for approximately 3 years. The treatments consisted of the oral administration of ibogaine or its salts in dosage ranges of 6 mg/kg to 19 mg/kg. The minimum effective dose was 400 mgs and dosage increases above 1000 mgs were found to be unnecessary. Treatments were effective in 71% of the cases.