Patents by Inventor Howard Seeherman

Howard Seeherman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OSTEOINDUCTIVE SUBSTRATES AND METHODS OF MAKING THE SAME
    Publication number: 20160082156
    Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule is loaded with an osteoinductive material, and then placed in contact with a biocompatible matrix material.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 24, 2016
    Inventors: Christopher G. WILSON, Eric J. Vanderploeg, Howard Seeherman, Zachary Decker, Eric Schmidt, Bethany Moore, Alexander Heubeck
  • OSTEOGENIC PROTEINS
    Publication number: 20160052984
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: April 6, 2015
    Publication date: February 25, 2016
    Inventors: John WOZNEY, Howard Seeherman, Christopher Todd Brown
  • Designer osteogenic proteins
    Patent number: 8952131
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: February 10, 2015
    Assignee: Wyeth LLC
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Wozney, Howard Seeherman, Z. Sean Juo, Valerie P. Calabro, Christopher Todd Brown
  • Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
    Patent number: 8507008
    Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: August 13, 2013
    Assignees: ETEX Corporation, Wyeth LLC
    Inventors: Rebecca Li, Howard Seeherman, Hyun Kim
  • DESIGNER OSTEOGENIC PROTEINS
    Publication number: 20120046227
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: WYETH LLC
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Wozney, Howard Seeherman, Z. Sean Juo, Valerie Calabro, Christopher Todd Brown
  • Calcium phosphate delivery vehicles for osteoinductive proteins
    Patent number: 8003133
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: August 23, 2011
    Assignees: Wyeth LLC, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • Injectable Calcium Phosphate Solid Rods and Pastes for Delivery of Osteogenic Proteins
    Publication number: 20100273706
    Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
    Type: Application
    Filed: July 2, 2010
    Publication date: October 28, 2010
    Inventors: Rebecca Li, Howard Seeherman, Hyun Kim
  • Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
    Patent number: 7771755
    Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: August 10, 2010
    Assignees: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Hyun Kim
  • CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS
    Publication number: 20100074876
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Application
    Filed: September 23, 2009
    Publication date: March 25, 2010
    Applicants: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • Calcium phosphate delivery vehicles for osteoinductive proteins
    Patent number: 7622139
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: November 24, 2009
    Assignees: Wyeth, ETEX Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
    Patent number: 7608580
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: October 27, 2009
    Assignees: Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
  • USE OF FIBROUS TISSUE INDUCING PROTEINS FOR HERNIA REPAIR
    Publication number: 20090156462
    Abstract: The present disclosure relates to hernia repair and methods for stimulating growth of fascia tissue employing compositions comprising fibrous tissue inducing proteins.
    Type: Application
    Filed: February 19, 2009
    Publication date: June 18, 2009
    Applicant: Wyeth
    Inventors: James H. Pickar, Joanne M. Archambault, Howard Seeherman
  • Calcium phosphate delivery vehicles for osteoinductive proteins
    Patent number: 7413753
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 19, 2008
    Assignees: Wyeth, Etex Corporation
    Inventors: Rebecca H. Li, Howard Seeherman
  • CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS
    Publication number: 20080096797
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 24, 2008
    Applicants: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • Bone Cement Mixing Systems and Related Methods
    Publication number: 20080065088
    Abstract: Bone cement mixing systems and related methods are disclosed. The bone cement mixing systems can include a first chamber, a second chamber, and a passage fluidly connecting the first and second chambers. A first piston can be disposed in the first chamber, and a second piston can be disposed in the second chamber.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 13, 2008
    Applicant: WYETH
    Inventors: Martin Hughes, Darren Seymour, Colin Turner, Paul Harmer, Richard Cornell, Howard Seeherman
  • INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS
    Publication number: 20070134342
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Application
    Filed: January 18, 2007
    Publication date: June 14, 2007
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
  • Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
    Patent number: 7226587
    Abstract: Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses compositions and methods for systemic administration of bone morphogenetic proteins for promotion of osteogenesis. These compositions and methods may be used in bone fracture healing and repair. These composition of the invention may be further utilized in increasing bone mineral density.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: June 5, 2007
    Assignee: Wyeth
    Inventors: Brian Clancy, Debra Pittman, Howard Seeherman
  • Use of fibrous tissue inducing proteins for hernia repair
    Publication number: 20070111937
    Abstract: The present disclosure relates to hernia repair and methods for stimulating growth of fascia tissue employing compositions comprising fibrous tissue inducing proteins.
    Type: Application
    Filed: March 23, 2006
    Publication date: May 17, 2007
    Inventors: James Pickar, Joanne Archambault, Howard Seeherman
  • Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
    Patent number: 7189392
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 13, 2007
    Assignees: Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
  • Use of sFRPs as markers of BMP activity
    Publication number: 20060166251
    Abstract: The disclosure provides assay systems for evaluating the presence of bone morphogenetic protein (BMP) activity in a cell by evaluating the gene expression of secreted Frizzled Related Protein 2 and 3 (sFRP2 and sFRP3). The sFRP2 and sFRP3 gene expression may be detected at the RNA or protein levels. The methods include methods for evaluating exogenous and endogenous BMP expression and utilize both genomic sFRP2 and sFRP3 genes and reporter constructs.
    Type: Application
    Filed: January 26, 2006
    Publication date: July 27, 2006
    Inventors: Joanne Archambault, Scott Jelinsky, Michael Agostino, Li Li, Howard Seeherman