Abstract: A device for accurately locate the tumor in a radiation therapy machine (RTM) based on the patient's CT image is disclosed. The device immobilizes a patient in a repeatable location when a CT scan is made and the radiation therapy is given. The device includes a base plate to support the patient, on which there are: a pair of pins to constrain the armpits of the patient, a pair of shoulder pads to constrain the shoulders of the patient, a headrest and head pads to constrain the head of the patient, markers, and a jaw restrainer secured to the head pads. Coordinate transformations will be used to locate the tumor in the RTM.

Abstract: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.

Abstract: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.

Abstract: A cuff clip secures a loose trouser leg to a shoe, and support the lower edge of such trouser leg above the ground. A fastener is embedded within a lower portion of the shoe, leaving a coupling head exposed outside the shoe. The cuff clip engages the bottom edge of the trouser leg. The cuff clip includes a snap coupler that mates with the coupling head of the fastener embedded within the shoe. An outwardly-directed exterior wall of the cuff clip includes a bottom lip and opposing side lips to releasably receive a rectangular logo.

Abstract: A system and a method are described for managing the process of simultaneously teaching a large number of students, who have a widely varying range of skills in a content area, by using individualized instruction. The system and the method achieve this by allowing the teacher's resources to be utilized more efficiently, which makes the teaching more effective. In addition, it allows the teacher to determine the mastery criteria and the scope and sequence of a content area. Students accelerate through a sequence of skills determined by the teacher using their prior knowledge until they encounter a skill deficiency. Pre- and post-testing is used in conjunction with highly-focused, individualized instruction, in a feedback-loop-cycle until the student masters the specific skill. The system and the method are applicable to any subject area where learning is enhanced by a sequential learning process.

Abstract: A cuff clip secures a loose trouser leg to a shoe, and supports the lower edge of such trouser leg above the ground. A fastener is secured to a lower portion of the shoe, leaving a coupling head or stud exposed outside the shoe. The cuff clip includes a channel to engage the bottom edge of the trouser leg. The cuff clip includes a snap coupler that mates with the coupling head or stud of the fastener embedded within the shoe. An exterior wall of the cuff clip is used to display a logo or other indicia. Such exterior wall has retaining lips to releasably receive indicia to be displayed thereon.

Abstract: This invention defines novel research and clinical laboratory methodology and compositions related thereto appropriate for use in (a) determining the presence of a neurodegenerative disease selected from the group limited solely to Charcot-Marie-Tooth disease, familial Alzheimer's disease, familial Parkinson's disease, Huntington's disease, spinal muscular atrophy, Friedreich'a ataxia, giant axon neuropathy, juvenile ceroid-lipofuscinosis, familial motor neuron diseases, juvenile diabetic polyneuropathy and Down's syndrome, (b) monitoring the ongoing status of the physiological expression of said disease and (c) screening candidate therapeutic drug agents for possible effectiveness.

Abstract: This invention defines novel compositions that can be used for clinical treatment of a class of chronic inflammatory diseases. Increased generation of carbonyl substances, namely aldehydes and ketones, occurs at sites of chronic inflammation and is common to the etiologies of all of the clinical disorders addressed herein. Such carbonyl substances are cytotoxic and additionally serve to perpetuate and disseminate the inflammatory process. This invention defines use of compositions, the orally administered required primary agents of which are primary amine derivatives of benzoic acid capable of covalently reacting with the carbonyl substances. p-Aminobenzoic acid (or PABA) is an example of the required primary agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group which reacts with carbonyl-containing substances and is tolerated by the body in relatively high dosages for extended periods.