Patents by Inventor Howard Stern
Howard Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240302349Abstract: Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting likelihood of the subject responding to a therapy, such as a cell therapy, e.g., a chimeric antigen receptor (CAR) T cell therapy. In some aspects, the predicting is based on detecting certain biomarkers of immune cells associated with and/or that correlate with response following administration of the therapy. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is likely to respond to the therapy. The present disclosure also provides methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment the biomarker. Also provided herein are reagents and kits for performing the methods.Type: ApplicationFiled: May 24, 2024Publication date: September 12, 2024Applicant: Juno Therapeutics, Inc.Inventors: Trevor DO, Howard STERN, Christina SWANSON
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Patent number: 12031975Abstract: Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting likelihood of the subject responding to a therapy, such as a cell therapy, e.g., a chimeric antigen receptor (CAR) T cell therapy. In some aspects, the predicting is based on detecting certain biomarkers of immune cells associated with and/or that correlate with response following administration of the therapy. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is likely to respond to the therapy. The present disclosure also provides methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment the biomarker. Also provided herein are reagents and kits for performing the methods.Type: GrantFiled: October 31, 2018Date of Patent: July 9, 2024Assignee: Juno Therapeutics, Inc.Inventors: Trevor Do, Howard Stern, Christina Swanson
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Publication number: 20210132042Abstract: Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting likelihood of the subject responding to a therapy, such as a cell therapy, e.g., a chimeric antigen receptor (CAR) T cell therapy. In some aspects, the predicting is based on detecting certain biomarkers of immune cells associated with and/or that correlate with response following administration of the therapy. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is likely to respond to the therapy. The present disclosure also provides methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment the biomarker. Also provided herein are reagents and kits for performing the methods.Type: ApplicationFiled: October 31, 2018Publication date: May 6, 2021Applicant: Juno Therapeutics, Inc.Inventors: Trevor DO, Howard STERN, Christina SWANSON
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Publication number: 20190323089Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: ApplicationFiled: July 2, 2019Publication date: October 24, 2019Applicant: Genentech, Inc.Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Patent number: 10385405Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: GrantFiled: November 30, 2016Date of Patent: August 20, 2019Assignee: Genentech, Inc.Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Publication number: 20170073777Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: ApplicationFiled: November 30, 2016Publication date: March 16, 2017Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Patent number: 9551033Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: GrantFiled: August 12, 2010Date of Patent: January 24, 2017Assignee: Genentech, Inc.Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Publication number: 20110151454Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: ApplicationFiled: August 12, 2010Publication date: June 23, 2011Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Publication number: 20100298156Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.Type: ApplicationFiled: June 4, 2008Publication date: November 25, 2010Inventors: Si Tuen Lee-Hoeflich, Howard Stern
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Publication number: 20100277717Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.Type: ApplicationFiled: October 30, 2009Publication date: November 4, 2010Applicant: Rudolph Technologies, Inc.Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauer
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Patent number: 7616328Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.Type: GrantFiled: November 7, 2007Date of Patent: November 10, 2009Assignee: Rudolph Technologies, Inc.Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauer
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Publication number: 20080165357Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.Type: ApplicationFiled: November 7, 2007Publication date: July 10, 2008Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauber
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Publication number: 20080062424Abstract: A compact ringlight that emulates the performance of a much larger ringlight is disclosed. The invention utilizes a ringlight source and a conical or cylindrical reflector such that light first crosses the optical axis and then is reflected back towards the inspection area. This light is particularly useful for inspecting electronic semiconductor devices.Type: ApplicationFiled: September 5, 2007Publication date: March 13, 2008Inventors: Mark Richard Shires, Howard Stern
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Publication number: 20050155087Abstract: The present invention is directed to a novel, target-blind approach to drug discovery. The concept is to model human phenotypes in a teleost, such as a zebrafish, and then screen compounds, e.g., small molecules, for their ability to alter the phenotype. Because the screen is performed with a whole vertebrate organism and uses a phenotype as the output, the need to first identify target genes is eliminated. This approach is powerful because a single screen can theoretically detect drugs affecting any target relevant to the phenotype being observed, even if those targets are not yet characterized.Type: ApplicationFiled: December 17, 2002Publication date: July 14, 2005Inventors: Leonard Zon, Howard Stern, Ryan Murphey
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Publication number: 20050112178Abstract: This invention relates to a nutritional kit for use in preparing an individual for a predetermined activity which requires a clean digestive tract, particularly the colon. Such predetemined activities include, but are not limited to, gastrointestinal surgery and colon screenings. Specifially, the present invention provides an individual low amounts of fat, dietary fiber and solid food content to minimize stool formation and/or facilitate removal of stool from the digestive tract prior to the predetermined activity. The present invention also provides the individual with sufficient calories and nutrition to enable the individual to conduct daily, routine activities while utilizing the present invention.Type: ApplicationFiled: August 10, 2004Publication date: May 26, 2005Inventor: Howard Stern
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Publication number: 20050092843Abstract: A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in an environment where the imager is anywhere from 1.5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector.Type: ApplicationFiled: November 16, 2004Publication date: May 5, 2005Inventors: John Dowling, Howard Stern, Luis Fizarella, Harry McKinley, Philip McKinley, Jason Lee
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Patent number: 6860428Abstract: A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in environment where the imager is anywhere from 1.5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector.Type: GrantFiled: September 11, 1998Date of Patent: March 1, 2005Assignee: Robotic Vision Systems Inc.Inventors: John H. Dowling, Howard Stern, Harry R. McKinley, Philip E. McKinley, Jason J. Lee, Luis Alberto Figarella
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Patent number: 6661521Abstract: An illumination apparatus is provided for a hand-held imager preferably to provide diffuse illumination for encoded symbology carried directly upon an article (component, etc) or upon a substrate carried by an article. The illumination apparatus is disposed proximate the front of the hand-held imager and is configured to permit light reflected from the target to pass through the illumination apparatus and onto a CCD image receiver. An array of unlensed LED's is disposed to cast approximately or substantially lambertian illumination in a direction away from the target to be imaged and into the hand-held housing to impinge upon surfaces of an illuminator to receive the illumination and, in turn, project efficient and diffuse dark field illumination through the array of unlensed LED's and towards and onto a location where a target to be imaged would be disposed.Type: GrantFiled: September 11, 1998Date of Patent: December 9, 2003Assignee: Robotic Vision Systems, Inc.Inventor: Howard Stern
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Publication number: 20030215127Abstract: A system and method for simultaneously obtaining a plurality of images of an object or pattern from a plurality of different viewpoints is provided. In an exemplary embodiment, proper image contrast is obtained by replacing the light sources of earlier systems with equivalent light sensitive devices and replacing the cameras of earlier systems with equivalent light sources. With such a system, bright-field images and dark-field images may be simultaneously obtained. In one aspect of the invention, a light source is positioned to illuminate at least a portion of an object. A plurality of light guides having input ends are positioned to simultaneously receive light reflected from the object and transmit the received light to a plurality of photodetectors. The light guides are arranged such that their respective input ends are spaced substantially equally along at least a portion of a surface of an imaginary hemisphere surrounding the object.Type: ApplicationFiled: March 12, 2003Publication date: November 20, 2003Inventors: Howard Stern, Fereydoun Maali
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Patent number: 6603874Abstract: A system and method for simultaneously obtaining a plurality of images of an object or pattern from a plurality of different viewpoints is provided. In an exemplary embodiment, proper image contrast is obtained by replacing the light sources of earlier systems with equivalent light sensitive devices and replacing the cameras of earlier systems with equivalent light sources. With such a system, bright-field images and dark-field images may be simultaneously obtained. In one aspect of the invention, a light source is positioned to illuminate at least a portion of an object. A plurality of light guides having input ends are positioned to simultaneously receive light reflected from the object and transmit the received light to a plurality of photodetectors. The light guides are arranged such that their respective input ends are spaced substantially equally along at least a portion of a surface of an imaginary hemisphere surrounding the object.Type: GrantFiled: March 3, 2000Date of Patent: August 5, 2003Assignee: Robotic Vision Systems, Inc.Inventors: Howard Stern, Fereydoun Maali