Patents by Inventor Howard Stern

Howard Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190323089
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Applicant: Genentech, Inc.
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Patent number: 10419516
    Abstract: A system and method for managing the delivery of targeted content. When a user desires to opt-out of receiving targeted content, the user registers with a do-not-target (DNT) registry and is issued a DNT cookie. The DNT cookie is a domain cookie that is stored on a user network access device. A provider of targeted content may look for the DNT cookie stored on the user's network access device. When the DNT cookie is not found, then the provider may deliver targeted content to the user. When the DNT cookie is found, then the provider may not deliver targeted content to the user. A Web site may offer the user an “override” cookie that allows that Web site to provide targeted content, or selected targeted content, even when the user has a DNT cookie. Alternatively, a DNT header can be added to a Web page request that indicates that the user does not want to receive targeted content. The DNT header may be overridden by an override cookie.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 17, 2019
    Assignee: TIME WARNER CABLE ENTERPRISES LLC
    Inventors: Howard Pfeffer, Peter Stern, Michael Dillon
  • Patent number: 10385405
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: August 20, 2019
    Assignee: Genentech, Inc.
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Publication number: 20170073777
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 16, 2017
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Patent number: 9551033
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: January 24, 2017
    Assignee: Genentech, Inc.
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Publication number: 20110151454
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Application
    Filed: August 12, 2010
    Publication date: June 23, 2011
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Publication number: 20100298156
    Abstract: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.
    Type: Application
    Filed: June 4, 2008
    Publication date: November 25, 2010
    Inventors: Si Tuen Lee-Hoeflich, Howard Stern
  • Publication number: 20100277717
    Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.
    Type: Application
    Filed: October 30, 2009
    Publication date: November 4, 2010
    Applicant: Rudolph Technologies, Inc.
    Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauer
  • Patent number: 7616328
    Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: November 10, 2009
    Assignee: Rudolph Technologies, Inc.
    Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauer
  • Publication number: 20080165357
    Abstract: A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.
    Type: Application
    Filed: November 7, 2007
    Publication date: July 10, 2008
    Inventors: Howard Stern, Mark Krichever, Murray Lawrence, James Drannbauber
  • Publication number: 20080062424
    Abstract: A compact ringlight that emulates the performance of a much larger ringlight is disclosed. The invention utilizes a ringlight source and a conical or cylindrical reflector such that light first crosses the optical axis and then is reflected back towards the inspection area. This light is particularly useful for inspecting electronic semiconductor devices.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 13, 2008
    Inventors: Mark Richard Shires, Howard Stern
  • Publication number: 20050155087
    Abstract: The present invention is directed to a novel, target-blind approach to drug discovery. The concept is to model human phenotypes in a teleost, such as a zebrafish, and then screen compounds, e.g., small molecules, for their ability to alter the phenotype. Because the screen is performed with a whole vertebrate organism and uses a phenotype as the output, the need to first identify target genes is eliminated. This approach is powerful because a single screen can theoretically detect drugs affecting any target relevant to the phenotype being observed, even if those targets are not yet characterized.
    Type: Application
    Filed: December 17, 2002
    Publication date: July 14, 2005
    Inventors: Leonard Zon, Howard Stern, Ryan Murphey
  • Publication number: 20050112178
    Abstract: This invention relates to a nutritional kit for use in preparing an individual for a predetermined activity which requires a clean digestive tract, particularly the colon. Such predetemined activities include, but are not limited to, gastrointestinal surgery and colon screenings. Specifially, the present invention provides an individual low amounts of fat, dietary fiber and solid food content to minimize stool formation and/or facilitate removal of stool from the digestive tract prior to the predetermined activity. The present invention also provides the individual with sufficient calories and nutrition to enable the individual to conduct daily, routine activities while utilizing the present invention.
    Type: Application
    Filed: August 10, 2004
    Publication date: May 26, 2005
    Inventor: Howard Stern
  • Publication number: 20050092843
    Abstract: A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in an environment where the imager is anywhere from 1.5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector.
    Type: Application
    Filed: November 16, 2004
    Publication date: May 5, 2005
    Inventors: John Dowling, Howard Stern, Luis Fizarella, Harry McKinley, Philip McKinley, Jason Lee
  • Patent number: 6860428
    Abstract: A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in environment where the imager is anywhere from 1.5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: March 1, 2005
    Assignee: Robotic Vision Systems Inc.
    Inventors: John H. Dowling, Howard Stern, Harry R. McKinley, Philip E. McKinley, Jason J. Lee, Luis Alberto Figarella
  • Patent number: 6661521
    Abstract: An illumination apparatus is provided for a hand-held imager preferably to provide diffuse illumination for encoded symbology carried directly upon an article (component, etc) or upon a substrate carried by an article. The illumination apparatus is disposed proximate the front of the hand-held imager and is configured to permit light reflected from the target to pass through the illumination apparatus and onto a CCD image receiver. An array of unlensed LED's is disposed to cast approximately or substantially lambertian illumination in a direction away from the target to be imaged and into the hand-held housing to impinge upon surfaces of an illuminator to receive the illumination and, in turn, project efficient and diffuse dark field illumination through the array of unlensed LED's and towards and onto a location where a target to be imaged would be disposed.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: December 9, 2003
    Assignee: Robotic Vision Systems, Inc.
    Inventor: Howard Stern
  • Publication number: 20030215127
    Abstract: A system and method for simultaneously obtaining a plurality of images of an object or pattern from a plurality of different viewpoints is provided. In an exemplary embodiment, proper image contrast is obtained by replacing the light sources of earlier systems with equivalent light sensitive devices and replacing the cameras of earlier systems with equivalent light sources. With such a system, bright-field images and dark-field images may be simultaneously obtained. In one aspect of the invention, a light source is positioned to illuminate at least a portion of an object. A plurality of light guides having input ends are positioned to simultaneously receive light reflected from the object and transmit the received light to a plurality of photodetectors. The light guides are arranged such that their respective input ends are spaced substantially equally along at least a portion of a surface of an imaginary hemisphere surrounding the object.
    Type: Application
    Filed: March 12, 2003
    Publication date: November 20, 2003
    Inventors: Howard Stern, Fereydoun Maali
  • Patent number: 6603874
    Abstract: A system and method for simultaneously obtaining a plurality of images of an object or pattern from a plurality of different viewpoints is provided. In an exemplary embodiment, proper image contrast is obtained by replacing the light sources of earlier systems with equivalent light sensitive devices and replacing the cameras of earlier systems with equivalent light sources. With such a system, bright-field images and dark-field images may be simultaneously obtained. In one aspect of the invention, a light source is positioned to illuminate at least a portion of an object. A plurality of light guides having input ends are positioned to simultaneously receive light reflected from the object and transmit the received light to a plurality of photodetectors. The light guides are arranged such that their respective input ends are spaced substantially equally along at least a portion of a surface of an imaginary hemisphere surrounding the object.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 5, 2003
    Assignee: Robotic Vision Systems, Inc.
    Inventors: Howard Stern, Fereydoun Maali
  • Patent number: 6429934
    Abstract: An imager for illuminating and imaging encoded symbology to facilitate decoding of the symbology and which provides both “bright field” and “dark field” illumination patterns is provided with an illumination directing device to direct the “bright field” illumination pattern into an alternative “dark field” illumination pattern. In one embodiment the illumination directing device takes the configuration of a disc that is selectively positionable in front of the imager and removable therefrom depending upon whether or not the illumination pattern is to be changed. The disc snap fits into a position at the front of the imager housing and includes a fresnel configured outer ring, a light blocking inner ring, and a light transmissive center. The fresnel configuration receives light and redirects the light forward of the imager and towards a center line passing through the device to provide the alternative illumination pattern.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: August 6, 2002
    Assignee: Robotic Vision Systems, Inc.
    Inventors: Sheila B. Dunn, John J. Merva, Howard Stern
  • Publication number: 20010053949
    Abstract: A secure tracking system and method of tracking for articles which are secure and include authentication and verification of users and user devices for data and information access and input. Each article to be tracked is provided with a unique secure indicia applied to the article and through which chronological histories are generated and maintained from creation of each article until at least the time when article is scrapped or otherwise destroyed. The articles can include manufactured components, assemblies, device and equipment for aircraft, automotive, military and other users, as well as jewelry and works of art.
    Type: Application
    Filed: March 13, 2001
    Publication date: December 20, 2001
    Applicant: Robotic Vision Systems, Inc.
    Inventors: Curtis W. Howes, C. Deniz Akyuz, Brian A. Arthur, Richard G. Ouellette, Howard Stern