Abstract: As it is generally known, when a medication fails to work properly it is increased in dosage and/or changed to another medication. Sulfonylurea medication has known to have secondary failure which increases blood glucose since the mid-1950s. (1) From new research, I have found a new way to overcome sulfonylurea Glimepiride's effectiveness to continue lowering blood glucose when secondary failure occurs which increases blood glucose. The new way is made by stopping taking it for 3 or 5 days which automatically also lower blood glucose and then resuming it which further lowers more blood glucose like the first day taking it. It is assumed that it works because it fools the human body like it's the first day when resuming taking it.