Patents by Inventor Howland D. T. Jones

Howland D. T. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230098156
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Application
    Filed: August 12, 2022
    Publication date: March 30, 2023
    Applicant: COR HEALTH, INC.
    Inventors: Robert G. MESSERSCHMIDT, Howland D.T. JONES
  • Patent number: 11428574
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 30, 2022
    Assignee: NUEON INC.
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones
  • Patent number: 11371882
    Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: June 28, 2022
    Assignee: NUEON INC.
    Inventors: Robert Messerschmidt, Howland D.T. Jones
  • Publication number: 20210364421
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Application
    Filed: June 11, 2021
    Publication date: November 25, 2021
    Applicant: NUEON INC.
    Inventors: Robert G. MESSERSCHMIDT, Howland D. T. JONES
  • Patent number: 11060967
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 13, 2021
    Assignee: NUEON INC.
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones
  • Publication number: 20210041290
    Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.
    Type: Application
    Filed: August 26, 2020
    Publication date: February 11, 2021
    Applicant: NUEON INC.
    Inventors: Robert MESSERSCHMIDT, Howland D.T. JONES
  • Patent number: 10760965
    Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: September 1, 2020
    Assignee: NUEON INC.
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones
  • Publication number: 20190226910
    Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.
    Type: Application
    Filed: September 20, 2018
    Publication date: July 25, 2019
    Inventors: Robert G. Messerschmidt, Howland D.T. Jones
  • Publication number: 20180136193
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Application
    Filed: December 19, 2017
    Publication date: May 17, 2018
    Inventors: Robert G. Messerschmidt, Howland D.T. Jones
  • Publication number: 20170350814
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Application
    Filed: June 12, 2017
    Publication date: December 7, 2017
    Inventors: Robert G. MESSERSCHMIDT, Howland D. T. JONES
  • Patent number: 9797836
    Abstract: A hyperspectral imaging flow cytometer can acquire high-resolution hyperspectral images of particles, such as biological cells, flowing through a microfluidic system. The hyperspectral imaging flow cytometer can provide detailed spatial maps of multiple emitting species, cell morphology information, and state of health. An optimized system can image about 20 cells per second. The hyperspectral imaging flow cytometer enables many thousands of cells to be characterized in a single session.
    Type: Grant
    Filed: February 18, 2013
    Date of Patent: October 24, 2017
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Michael B. Sinclair, Howland D. T. Jones
  • Publication number: 20150338338
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Application
    Filed: February 27, 2015
    Publication date: November 26, 2015
    Inventors: Robert G. MESSERSCHMIDT, Howland D. T. JONES
  • Patent number: 8557031
    Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: October 15, 2013
    Assignee: Sandia Corporation
    Inventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
  • Patent number: 8530002
    Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: September 10, 2013
    Assignee: Sandia Corporation
    Inventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
  • Patent number: 8529681
    Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: September 10, 2013
    Assignee: Sandia Corporation
    Inventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
  • Patent number: 7202091
    Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: April 10, 2007
    Assignee: InLight Solutions, Inc.
    Inventors: Howland D. T. Jones, David J. Nunez, Stephen J. Vanslyke, Robert D. Johnson, Edward L. Hull
  • Publication number: 20040241736
    Abstract: A method and apparatus for determining an attribute of a sample from a spectrum of the sample. The invention comprises samplers and methods of sampling that provide controlled optical pathlengths through the sample, increasing the accuracy of the attribute determinations. The invention is applicable, for example, in determining analyte concentrations in biological samples, such as concentrations of analytes such as glucose in human blood.
    Type: Application
    Filed: May 21, 2004
    Publication date: December 2, 2004
    Inventors: Shonn P. Hendee, Howland D. T. Jones, Dashiell A. Birnkrant, Robert D. Johnson, Russell E. Abbink, Robert G. Messerschmidt
  • Publication number: 20040082070
    Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.
    Type: Application
    Filed: October 28, 2002
    Publication date: April 29, 2004
    Inventors: Howland D. T. Jones, David J. Nunez, Stephen J. Vanslyke, Robert D. Johnson, Edward L. Hull
  • Publication number: 20040027659
    Abstract: A sample holder comprising a material that is functionally transparent to wavelengths of light that are important to visual analysis of the sample, and to wavelengths of light that are important to spectroscopic analysis of the sample. Embodiments of the invention are amenable to total internal reflection of light useful in spectroscopic analysis. Specific materials and configurations are described. Methods and apparatuses using such sample holders for measurement of sample properties, including cancer screening of cervical samples, are described.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 12, 2004
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones, Robert D. Johnson, V. Gerald Grafe
  • Publication number: 20030087456
    Abstract: An apparatus and method for infrared spectral analysis of samples to determine if the samples are normal or abnormal or to otherwise classify the sample. More specifically, the apparatus and method classify the sample on the basis of attenuation of infrared radiation at different wavelengths using a within-sample variance model. Further, the method and apparatus can include merging the output of multivariate classification models with the within-sample variance model applied to the infrared spectra sample such that their combined output results in a classification accuracy that is greater than any single model. The invention is useful in classifying, for example, biological samples such as human tissue, including cervical cells.
    Type: Application
    Filed: October 2, 2002
    Publication date: May 8, 2003
    Inventors: Howland D.T. Jones, Craig M. Gardner, Edward L. Hull, Kristin A. Nixon, M. Ries Robinson