Patents by Inventor Hrayr S. Karagueuzian

Hrayr S. Karagueuzian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6094593
    Abstract: A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: July 25, 2000
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, George A. Diamond, Steven S. Khan, Timothy A. Denton, Steven Evans
  • Patent number: 6021345
    Abstract: A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation, that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: February 1, 2000
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, Timothy A. Denton
  • Patent number: 5817132
    Abstract: An implanted defibrillator continuously monitors a patient's heart to detect the presence of fibrillation and repeatedly, automatically computes the approximate entropy of a series of data representing the fibrillating heart at a moment in time. The first approximate entropy score that meets a predetermined relation with respect to a predetermined threshold value activates an energy delivery system to defibrillate the heart with a low level shock. The process continues until defibrillation is successful. An external defibrillator incorporates the approximate entropy algorithm to achieve low level defibrillation. A method is disclosed which times the delivery of a defibrillating shock to a fibrillating heart to coincide with the moment that the defibrillation threshold is at a minimum.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: October 6, 1998
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, Peng-Sheng Chen
  • Patent number: 5678561
    Abstract: A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation, that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: October 21, 1997
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, George A. Diamond, Steven S. Khan, Timothy A. Denton, Steven Evans
  • Patent number: 5643325
    Abstract: A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
    Type: Grant
    Filed: January 24, 1996
    Date of Patent: July 1, 1997
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, George A. Diamond, Steven S. Khan, Timothy A. Denton, Steven Evans
  • Patent number: 5555889
    Abstract: A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation, that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: September 17, 1996
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hrayr S. Karagueuzian, George A. Diamond, Steven S. Khan, Timothy A. Denton, Steven Evans