Patents by Inventor Hsiang-Ying Lee

Hsiang-Ying Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient generation of human red blood cells via enriching peripheral blood erythroid progenitors
    Patent number: 11371019
    Abstract: A population of early-stage burst-forming unit-eryhtoid (BFU-E) cells characterized by low expression of the Type III Transforming Growth Factor ? Receptor (TGFRPIII) and uses thereof for producing red blood cells in vitro, genotoxicity analysis of chemicals, drug sensitivity assessment, and drug development. Also described herein are methods for producing the population of early-stage BFU-E cells and methods for producing red blood cells.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: June 28, 2022
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Xiaofei Gao, Hsiang-Ying Lee
  • IN VITRO PRODUCTION OF RED BLOOD CELLS WITH PROTEINS COMPRISING SORTASE RECOGNITION MOTIFS
    Publication number: 20200069736
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Application
    Filed: September 16, 2019
    Publication date: March 5, 2020
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • In vitro production of red blood cells with proteins comprising sortase recognition motifs
    Patent number: 10471099
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 12, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • EFFICIENT GENERATION OF HUMAN RED BLOOD CELL VIA ENRICHING PERIPHERAL BLOOD ERYTHROID PROGENITORS
    Publication number: 20190093080
    Abstract: A population of early-stage burst-forming unit-eryhtoid (BFU-E) cells characterized by low expression of the Type III Transforming Growth Factor ? Receptor (TGFRPIII) and uses thereof for producing red blood cells in vitro, genotoxicity analysis of chemicals, drug sensitivity assessment, and drug development. Also described herein are methods for producing the population of early-stage BFU-E cells and methods for producing red blood cells.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 28, 2019
    Applicant: Whitehead Institute for Biomedical Reseach
    Inventors: Harvey Lodish, Xiaofei Gao, Hsiang-Ying Lee
  • IN VITRO PRODUCTION OF RED BLOOD CELLS WITH SORTAGGABLE PROTEINS
    Publication number: 20160082046
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 24, 2016
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Kundrat, Novalia Pishesha