Abstract: Described herein are pharmaceutical compositions and methods for treating and preventing conformational diseases such as, TDP-43 proteinopathies, SMA, amyloid positive cancer, normal and premature aging. Also disclosed are in vitro screening methods for screening a therapeutic candidate to treat conformation diseases, by measuring the expression level of prion-like folding of aggregation-prone proteins or a P53 aggregate.

Abstract: A resistive random access memory (RRAM) including a substrate, a conductive layer, a resistive switching layer, a copper-containing oxide layer, and an electron supply layer is provided. The conductive layer is disposed on the substrate. The resistive switching layer is disposed on the conductive layer. The copper-containing oxide layer is disposed on the resistive switching layer. The electron supply layer is disposed on the copper-containing oxide layer.