Abstract: A method for manufacturing anisotropic polymer particles includes the steps of: (a) preparing on a substrate a polymeric composite which includes a film of a first polymer and a plurality of microspheres of a second polymer, (b) subjecting the polymeric composite on the substrate to a first solvent vapor annealing treatment in a vapor atmosphere of a first solvent, and (c) after step b), subjecting the polymeric composite on the substrate to a second solvent vapor annealing treatment in a vapor atmosphere of a second solvent so as to transform the microspheres of the second polymer into the anisotropic polymer particles.