Patents by Inventor Hsiao-hua Yu
Hsiao-hua Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210154472Abstract: Nano-patterned devices for triggered intracellular delivery of active materials are disclosed. The device may comprise a nano-sized polyelectrolyte multilayer (PEM) comprising at least one layer of an electroactive polyelectrolyte polymer, where the PEM is configured to hold or receive an active material to be disposed within the multilayer and to release the active material under an electric field.Type: ApplicationFiled: November 25, 2020Publication date: May 27, 2021Inventors: Roy SHENHAR, Meital RECHES, Hsiao-hua YU
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Patent number: 10444233Abstract: A device for capturing preselected cell types from a fluid sample that includes a plurality of cell types includes a substrate, a plurality of nanowires at least one of attached to or integral with a surface of the substrate such that each nanowire of the plurality of nanowires has an unattached end, and a layer of temperature-responsive material formed on at least the unattached end of each of the plurality of nanowires. The layer of temperature-responsive material has a compact configuration at a first temperature and an expanded configuration at a second temperature so as to facilitate release of cells captured at the first temperature to be released at the second temperature.Type: GrantFiled: July 31, 2013Date of Patent: October 15, 2019Assignees: The Regents of the University of California, RikenInventors: Hsian-Rong Tseng, Shuang Hou, Libo Zhao, Hsiao-Hua Yu, Shyh-Chyang Luo, Haichao Zhao
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Publication number: 20150260710Abstract: A device for capturing preselected cell types from a fluid sample that includes a plurality of cell types includes a substrate, a plurality of nanowires at least one of attached to or integral with a surface of the substrate such that each nanowire of the plurality of nanowires has an unattached end, and a layer of temperature-responsive material formed on at least the unattached end of each of the plurality of nanowires. The layer of temperature-responsive material has a compact configuration at a first temperature and an expanded configuration at a second temperature so as to facilitate release of cells captured at the first temperature to be released at the second temperature.Type: ApplicationFiled: July 31, 2013Publication date: September 17, 2015Inventors: Hsian-Rong Tseng, Shuang Hou, Libo Zhao, Hsiao-Hua Yu, Shyh-Chyang Luo, Haichao Zhao
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Patent number: 8114955Abstract: The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described.Type: GrantFiled: September 26, 2006Date of Patent: February 14, 2012Assignee: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Hsiao-Hua Yu, Emril Mohamed Ali, Eric Assen B Kantchev
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Publication number: 20110028676Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from ?-? stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.Type: ApplicationFiled: February 8, 2010Publication date: February 3, 2011Applicants: Massachusetts Institute of Technology, Secreatary of the Navy, United StatesInventors: Patrick A. Anquetil, Ian W. Hunter, John D. Madden, Peter G. Madden, Anthony E. Pullen, Timothy M. Swager, Bing Xu, Hsiao-hua Yu
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Publication number: 20100126880Abstract: The invention provides a compound of structure (I): wherein X is S, O or NRN, where RN is H or alkyl; L is a linker group; Q is a group capable of binding with dsDNA; G and G? are, independently, absent or have between 1 and 20 main chain atoms; FG is a functional moiety comprising at least one O or N atom or a transition metal complex; and R is selected from the group consisting of H, alkyl, alkoxy or OCRaRb coupled to an atom in L so as to form a six-membered ring. Ra and Rb are independently H or optionally substituted alkyl.Type: ApplicationFiled: November 9, 2007Publication date: May 27, 2010Inventors: Hsiao-Hua Yu, Jackie Y. Ying, Natalia C. Tansil, Eric Assen B. Kantchev
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Publication number: 20100116682Abstract: The present invention generally relates to electronic devices and methods. In some cases, the invention provides a sensor device comprising a pair of interdigitated microelectrodes (60), coated with an electrically conducting polymer material (70). The microelectrodes (60) may be surrounded by a first electrode (22), a second electrode (40), and a hydrophobic wall (50).Type: ApplicationFiled: September 13, 2007Publication date: May 13, 2010Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Pavel Neuzil, Hsiao-Hua Yu, Jackie Y. Ying
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Publication number: 20100048815Abstract: The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described.Type: ApplicationFiled: September 26, 2006Publication date: February 25, 2010Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jackie Y. Ying, Hsiao-Hua Yu, Emril Mohamed Ali, Eric Assen B. Kantchev
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Patent number: 7658868Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from ?-? stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.Type: GrantFiled: November 21, 2006Date of Patent: February 9, 2010Assignees: Massachusetts Institute of Technology, The United States of America as represented by the Secretary of the NavyInventors: Patrick A Anquetil, Ian W Hunter, John D Madden, Peter G Madden, Anthony E Pullen, Timothy M Swager, Bing Xu, Hsiao-Hua Yu
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Publication number: 20090186419Abstract: The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors.Type: ApplicationFiled: January 20, 2006Publication date: July 23, 2009Applicant: Agency for Science ,Technology and ResearchInventors: Jackie Y. Ying, Hsiao-Hua Yu, Emril Mohamed Ali
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Publication number: 20070215839Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from ?-? stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.Type: ApplicationFiled: November 21, 2006Publication date: September 20, 2007Applicant: Massachusetts Institute of TechnologyInventors: Patrick Anquetil, Ian Hunter, John Madden, Peter Madden, Anthony Pullen, Timothy Swager, Bing Xu, Hsiao-hua Yu
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Publication number: 20070141726Abstract: The present invention relates to methods for determination of an analyte. The invention provides various methods involving exposure of a luminescent material to an analyte wherein, upon interaction with the analyte, a change in luminescence may be observed as a function of the duration of exposure to electromagnetic radiation, thereby determining the analyte. Some embodiments of the invention include the use of highly emissive semiconductor nanocrystals.Type: ApplicationFiled: December 19, 2005Publication date: June 21, 2007Applicant: Agency for Science, Technology and ResearchInventors: Jackie Ying, Hsiao-Hua Yu, Emril Ali, Nikhil Jana
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Patent number: 7138075Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from ?—? stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.Type: GrantFiled: March 19, 2003Date of Patent: November 21, 2006Assignee: Massachusetts Institute of TechnologyInventors: Patrick A. Anquetil, Ian W. Hunter, John D. Madden, Peter G. Madden, Anthony E. Pullen, Timothy M. Swager, Bing Xu, Hsiao-hua Yu
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Publication number: 20040007695Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from &pgr;-&pgr; stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.Type: ApplicationFiled: March 19, 2003Publication date: January 15, 2004Inventors: Patrick A. Anquetil, Ian W. Hunter, John D. Madden, Peter G. Madden, Anthony E. Pullen, Timothy M. Swager, Bing Xu, Hsiao-hua Yu