Patents by Inventor Hsieh-Hsun HO

Hsieh-Hsun HO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230201280
    Abstract: Disclosed herein are methods for improving gastrointestinal barrier function, alleviating a gastrointestinal barrier dysfunction-associated disorder, and inhibiting growth of enteric pathogenic bacteria using a composition containing Lactobacillus rhamnosus MP108, Bifidobacterium longum subsp. infantis BLI-02, and Bifidobacterium animalis subsp. lactis BB-115, which are deposited at the China General Microbiological Culture Collection Center (CGMCC) respectively under accession numbers CGMCC 21225, CGMCC 15212, and CGMCC 21840. A number ratio of Lactobacillus rhamnosus MP108, Bifidobacterium longum subsp. infantis BLI-02, and Bifidobacterium animalis subsp. lactis BB-115 ranges from 1:0.2:0.67 to 1:9:9.
    Type: Application
    Filed: April 27, 2022
    Publication date: June 29, 2023
    Inventors: Hsieh-Hsun HO, Jui-Fen CHEN, Yi-Wei KUO, Chi-Huei LIN
  • Publication number: 20230173000
    Abstract: The present invention discloses an anti-aging composition, which includes: (a) isolated lactic acid bacterial strains or a fermented product thereof; and (b) an excipient, a diluent, or a carrier; wherein the isolated lactic acid bacterial strains include: Bifidobacterium bifidum VDD088 strains, Bifidobacterium breve Bv-889 strains, and Bifidobacterium longum BLI-02 strains. The present invention further provides a method for preventing aging by administering the foregoing anti-aging composition to a subject in need thereof.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 8, 2023
    Inventors: Hsieh-Hsun Ho, Yi-Wei Kuo, Wen-Yang Lin, Jia-Hung Lin, Yen-Yu Huang, Chi-Huei Lin, Shin-Yu Tsai
  • Publication number: 20230149480
    Abstract: The present invention provides a lactic acid bacterial composition for inhibiting the activity of Escherichia coli and/or treating or preventing jaundice, the composition including: a Bifidobacterium animalis subsp. lactis CP-9 strain or a Lactobacillus salivarius subsp. salicinius AP-32 strain. The present invention further provides a method for inhibiting growth of Escherichia coli, the method including the step(s) of: administering the foregoing lactic acid bacterial composition to a subject in need thereof. The present invention additionally provides a method for treating or preventing jaundice, the method including the step(s) of: administering the foregoing lactic acid bacterial composition to a subject in need thereof.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 18, 2023
    Inventors: Hsieh-Hsun HO, Yi-Wei KUO, Jia-Hung LIN, Hui-Shan WANG, Yen-Yu HUANG, Wen-Yang LIN, Ko-Chiang HSIA
  • Publication number: 20230131386
    Abstract: Disclosed herein is a probiotic culture prepared by cultivating a probiotic mixture in a collagen solution. The probiotic mixture includes, in a number ratio of, Lactobacillus acidophilus TYCA06 deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 15210, to Lactobacillus salivarius subsp. salicinius AP-32 deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2011127, and to Bifidobacterium animalis subsp. lactis CP-9 deposited at the CCTCC under an accession number CCTCC M 2014588, which ranges from 1:0.125:0.125 to 1:8:8. Also disclosed herein is use of the probiotic culture for improving skin condition and for inhibiting pathogenic infection.
    Type: Application
    Filed: April 21, 2022
    Publication date: April 27, 2023
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yu-Fen HUANG, Tsai-Hsuan YI, Yi-Wei KUO, Jia-Hung LIN, Shin-Yu TSAI
  • Publication number: 20230100778
    Abstract: Disclosed herein is a method for promoting growth of a probiotic microorganism. The method includes cultivating the probiotic microorganism in a growth medium containing a fermented culture of lactic acid bacterial strains that include Lactobacillus salivarius subsp. salicinius AP-32 deposited at the China Center for Type Culture Collection (CCTCC) under CCTCC M 2011127, Lactobacillus plantarum LPL28 deposited at the China General Microbiological Culture Collection Center (CGMCC) under CGMCC 17954, Lactobacillus acidophilus TYCA06 deposited at the CGMCC under CGMCC 15210, and Bifidobacterium longum subsp. infantis BLI-02 deposited at the CGMCC under CGMCC 15212.
    Type: Application
    Filed: April 19, 2022
    Publication date: March 30, 2023
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yu-Fen HUANG, Cheng-Chi LIN, Chen-Hung HSU, Tsai-Hsuan YI, Yu-Wen CHU, Yi-Wei KUO, Jui-Fen CHEN, Shin-Yu TSAI
  • Patent number: 11612171
    Abstract: A food composition and pharmaceutical composition with strains of lactic acid bacteria for modulating blood glucose are provided, comprising an isolated lactic acid bacteria strain. The isolated lactic acid bacteria strain is at least one selected from a group including a GL-104 strain of Lactobacillus reuteri (CCTCC NO: M209138), an AP-32 strain of Lactobacillus salivarius subsp. salicinius (CCTCC NO: M2011127), a TYCA06 strain of Lactobacillus acidophilus (CGMCC No: 15210), and an MH-68 strain of Lactobacillus johnsonii (CCTCC NO: M2011128), or a combination thereof.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: March 28, 2023
    Assignee: GLAC BIOTECH CO., LTD.
    Inventors: Pei-Shan Hsieh, Chung-Wei Kuo, Yi-Chun Tsai, Hsieh-Hsun Ho, Yi Wei Kuo
  • Publication number: 20230031534
    Abstract: Disclosed herein are methods for alleviating an enteric pathogenic bacterium-associated disorder and inhibiting growth of enteric pathogenic bacteria using a composition containing cultures of Lactobacillus rhamnosus MP108 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225, and Lactobacillus paracasei MP137 which is deposited at the CGMCC under an accession number CGMCC 21224.
    Type: Application
    Filed: January 11, 2022
    Publication date: February 2, 2023
    Inventors: Hsieh-Hsun HO, Yi-Wei Kuo, Ching-Wei Chen, Jui-Fen Chen, Shu-Hui Chen
  • Publication number: 20230036629
    Abstract: Disclosed herein are methods for inhibiting growth of oral pathogenic bacteria and alleviating an oral pathogenic bacteria-associated disorder using a culture of at least one lactic acid bacterial strain selected from the group consisting of Lactobacillus rhamnosus MP108 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225, and Lactobacillus paracasei MP137 which is deposited at the CGMCC under an accession number CGMCC 21224.
    Type: Application
    Filed: January 11, 2022
    Publication date: February 2, 2023
    Inventors: Hsieh-Hsun Ho, Yi-Wei Kuo, Ching-Wei Chen, Wen-Yang Lin, Jui-Fen Chen, Shu-Hui Chen
  • Publication number: 20230000930
    Abstract: A composition, which comprises at least one of an AP-32 strain of Lactobacillus salivarius subsp. salicinius, a BLI-02 strain of Bifidobacterium longum subsp. infantis and fermentation metabolites thereof, has a physiological activity of elevating ability of brain tissue. The present invention may be used in form of a food composition or a pharmaceutical composition to elevate the ability of brain tissue.
    Type: Application
    Filed: April 22, 2022
    Publication date: January 5, 2023
    Inventors: HSIEH-HSUN HO, YI WEI KUO, KO-CHIANG HSIA, WEN-YANG LIN, JIA-HUNG LIN, CHI-HUEI LIN, CHENG-RUEI LIU, SHU-HUI CHEN
  • Publication number: 20220347238
    Abstract: The present invention provides a lactic acid bacteria composition, which comprises: a Lactobacillus plantarum PL-02 strain, a Lactobacillus acidophilusTYCA06 strain, a Lactobacillus casei CS-773 strain, and a physiologically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 3, 2022
    Inventors: Chi-Chang HUANG, Mon-Chien LEE, Yi-Ju HSU, Hsieh-Hsun HO, Yi-Wei KUO, Wen-Yang LIN, Jia-Hung LIN, Chi-Huei LIN
  • Publication number: 20220313752
    Abstract: Disclosed herein is a probiotic composition that includes Lactobacillus salivarius subsp. salicinius AP-32, Lactobacillus johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9, which are deposited at the China Center for Type Culture Collection (CCTCC) respectively under accession numbers CCTCC M 2011127, CCTCC M 2011128, and CCTCC M 2014588. A number ratio of Lactobacillus salivarius subsp. salicinius AP-32, Lactobacillus johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 ranges from 1:0.1:0.1 to 1:1:8. Also disclosed herein is use of the probiotic composition for alleviating type 1 diabetes mellitus (T1DM).
    Type: Application
    Filed: November 18, 2021
    Publication date: October 6, 2022
    Inventors: Hsieh-Hsun HO, Wen-Yang LIN, Yi-Wei KUO, Yen-Yu HUANG, Jia-Hung LIN
  • Publication number: 20220315960
    Abstract: A method for producing ?-aminobutyric acid includes cultivating, in a culture medium containing glutamic acid or a salt thereof, a probiotic composition including at least one lactic acid bacterial strain selected from the group consisting of Bifidobacterium breve CCFM1025 which is deposited at the Guangdong Microbial Culture Collection Center under an accession number GDMCC 60386, Lactobacillus acidophilus TYCA06, Lactobacillus plantarum LPL28, and Bifidobacterium longum subsp. infantis BLI-02 which are deposited at the China General Microbiological Culture Collection Center respectively under accession numbers CGMCC 15210, CGMCC 17954, and CGMCC 15212, Lactobacillus salivarius subsp. salicinius AP-32 which is deposited at the China Center for Type Culture Collection under an accession number CCTCC M 2011127, and combinations thereof.
    Type: Application
    Filed: January 7, 2022
    Publication date: October 6, 2022
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yu-Fen HUANG, Chen-Hung HSU, Wen-Yang LIN, Yi-Wei KUO, Shin-Yu TSAI
  • Publication number: 20220313756
    Abstract: Disclosed herein is use of a culture of at least one lactic acid bacterial strain for alleviating a Helicobacter pylori-associated disorder. The at least one lactic acid bacterial strain is selected from the group consisting of Lactobacillus rhamnosus F-1 which is deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2011124, Lactobacillus plantarum LPL28 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 17954, and Lactobacillus acidophilus TYCA06 which is deposited at the CGMCC under an accession number CGMCC 15210.
    Type: Application
    Filed: October 1, 2021
    Publication date: October 6, 2022
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yi-Wei KUO, Chi-Huei LIN, Jui-Fen CHEN
  • Publication number: 20220273734
    Abstract: Disclosed herein are methods for reducing purine content in an edible material and alleviating a disorder of uric acid metabolism using Lactobacillus plantarum TSP05 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 16710.
    Type: Application
    Filed: December 6, 2021
    Publication date: September 1, 2022
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yi-Wei KUO, Jui-Fen CHEN
  • Publication number: 20220273735
    Abstract: The invention provides a method of increasing an amount of oral immunoglobulin A (IgA) and/or inhibiting oral pathogens in a subject in need thereof, which utilizes a composition including a therapeutically effective amount of probiotics as an effective ingredient. The probiotics include Lactobacillus plantarum LPL28, which can efficiently increase the amount of oral IgA and/or inhibit the oral pathogens, and thus have a potential to prevent teeth cavities and/or periodontal diseases.
    Type: Application
    Filed: October 27, 2021
    Publication date: September 1, 2022
    Inventors: Hsieh-Hsun Ho, Wen-Yang Lin, Yi-Wei Kuo, Yen-Yu Huang, Jia-Hung Lin, Chi-Huei Lin, Cheng-Ruei Liu, Shu-Hui Chen
  • Publication number: 20220265736
    Abstract: Disclosed herein is a probiotic composition including Lactobacillus salivarius subsp. salicinius AP-32 that is deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2011127, and Bifidobacterium longum subsp. longum OLP-01 that is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 17345. Also disclosed herein are use of at least one of the abovementioned lactic acid bacterial strains for treating obesity and/or an obesity-related disorder, and for inhibiting fat absorption.
    Type: Application
    Filed: October 1, 2021
    Publication date: August 25, 2022
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yu-Fen HUANG, Yi-Wei KUO, Wen-Yang LIN, Yen-Yu HUANG
  • Publication number: 20220104527
    Abstract: A food composition and pharmaceutical composition with strains of lactic acid bacteria for reducing blood uric acid concentration are provided, comprising at least one or two isolated lactic acid bacteria strains selected from the following two: TSF331 (Lactobacillus fermentum) and TSR332 (Lactobacillus reuteri).
    Type: Application
    Filed: June 16, 2021
    Publication date: April 7, 2022
    Inventors: PEI-SHAN HSIEH, HSIEH-HSUN HO, YI-CHUN TSAI, CHUNG-WEI KUO
  • Publication number: 20210401907
    Abstract: The present invention provides a topical composition having a fermented product of lactic acid bacteria synbiotics as an active ingredient. The fermented product of lactic acid bacteria synbiotics is obtained by performing a fermenting step with lactic acid bacteria and a deactivating step on a fermenting substrate. The lactic acid bacteria are consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9 and Lactobacillus acidophilus TYCA06. The fermenting substrate includes animal protein, plant protein and/or plant extracts. The aforementioned fermented product of lactic acid bacteria synbiotics can effectively inhibit the growth of Staphylococcus aureus and/or Propionibacterium acnes, and can be used in the topical composition.
    Type: Application
    Filed: March 18, 2021
    Publication date: December 30, 2021
    Inventors: Hsieh-Hsun Ho, Yi-Wei Kuo, Ching-Wei Chen, Yu-Fen Huang, Jia-Hung Lin
  • Publication number: 20210401906
    Abstract: A composition for promoting defecation includes a cell culture of at least one lactic acid bacterial strain which is substantially free of cells. The least one lactic acid bacterial strain is selected from the group consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus acidophilus TYCA06, which are respectively deposited at the Bioresource Collection and Research Center (BCRC) under accession numbers BCRC 910437, BCRC 910645 and BCRC 910813. Also disclosed is a method for promoting defecation, including administering to a subject in need thereof an effective amount of the composition.
    Type: Application
    Filed: March 17, 2021
    Publication date: December 30, 2021
    Inventors: Hsieh-Hsun Ho, Ching-Wei Chen, Yi-Wei Kuo, Yu-Fen Huang, Cheng-Chi Lin
  • Publication number: 20210401908
    Abstract: The present invention provides a composition for promoting defecation, which includes: a fermentation powder of lactic acid bacteria and a physiologically acceptable excipient, diluent, or carrier. The fermentation powder includes: a fermentation product of lactic acid bacteria, the fermentation product is obtained by incubating lactic acid bacterial strains in a culture medium containing milk, milk powders, casein, soy beans, bean products, or whey, and the lactic acid bacterial strains include: a Lactobacillus salivarius subsp. salicinius AP-32 strain, a Lactobacillus plantarum LPL28 strain, a Lactobacillus acidophilus TYCA06 strain, and a Bifidobacterium longum subsp. infantis BLI-02 strain.
    Type: Application
    Filed: May 3, 2021
    Publication date: December 30, 2021
    Inventors: Hsieh-Hsun HO, Ching-Wei CHEN, Yi-Wei KUO, Yu-Fen HUANG, Jui-Fen CHEN, Cheng-Chi LIN