Patents by Inventor Hsien C. Cheng
Hsien C. Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5739150Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.Type: GrantFiled: June 1, 1995Date of Patent: April 14, 1998Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5650416Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.Type: GrantFiled: May 24, 1995Date of Patent: July 22, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5631268Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.Type: GrantFiled: May 24, 1995Date of Patent: May 20, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5602147Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.Type: GrantFiled: June 1, 1995Date of Patent: February 11, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5596003Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.Type: GrantFiled: June 1, 1995Date of Patent: January 21, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5541200Abstract: Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.Type: GrantFiled: May 24, 1995Date of Patent: July 30, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5476861Abstract: Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.Type: GrantFiled: July 28, 1994Date of Patent: December 19, 1995Assignee: Merrell Dow Pharmaceuricals Inc.Inventors: Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5436246Abstract: The present invention is directed to a new class of 2-optionally substituted-4-piperazine-benzothiophene derivatives of the formula ##STR1## in which Y is represented by hydrogen or C.sub.1-3 alkyl; R is represented by a substituent selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, --CF.sub.3, --OCF.sub.3, and --OH; R.sub.1 is represented by hydrogen, cycloalkyl, C.sub.1-6 alkyl, phenyl optionally substituted, phenylalkyl, or phenylamidoalkyl; X is represented by hydrogen, --(CH.sub.2).sub.n X.sub.1, CH=CHX.sub.1 or CHX.sub.2 --(CH.sub.2).sub.q --CH.sub.3 ; n is an integer from 0-2; q is either the integer 0 or 1; X.sub.1 is represented by --OH--,--OR.sub.2, --NR.sub.2 R.sub.3, --CO.sub.2 R.sub.2, --CONR.sub.2 R.sub.3, --CN, or --COR.sub.2 ; R.sub.2 and R.sub.3 are each independently represented by hydrogen, C.sub.1-4 alkyl, phenyl optionally substituted, phenylalkyl, or R.sub.2 and R.sub.3 together form a (CH.sub.2).sub.m cycloalkyl, where m=2- 6; X.sub.2 is --OR.Type: GrantFiled: September 15, 1993Date of Patent: July 25, 1995Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Ronald C. Bernotas, Jeffrey S. Sprouse, Hsien C. Cheng
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Patent number: 5380731Abstract: The present invention is directed to a new class of piperidinyl benzimidazoles that are useful in the treatment of allergic disorders.Type: GrantFiled: August 17, 1993Date of Patent: January 10, 1995Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Albert A. Carr, John M. Kane, Hsien C. Cheng
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Patent number: 5371093Abstract: Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.Type: GrantFiled: February 24, 1994Date of Patent: December 6, 1994Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Albert A. Carr, George D. Maynard, John M. Kane, Hsien C. Cheng, Mark W. Dudley
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Patent number: 5198433Abstract: Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.Type: GrantFiled: July 21, 1992Date of Patent: March 30, 1993Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Norbert L. Wiech, Hsien C. Cheng, John M. Kane
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Patent number: 5158945Abstract: Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.Type: GrantFiled: March 11, 1992Date of Patent: October 27, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Hsien C. Cheng, Norbert L. Wiech, John M. Kane
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Patent number: 5128337Abstract: Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.Type: GrantFiled: September 23, 1991Date of Patent: July 7, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Norbert L. Wiech, Hsien C. Cheng, John M. Kane
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Patent number: 5106845Abstract: The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH.sub.2).sub.n in which n is an integer from 2-10, ##STR2## A is a substituent selected from the group consisting of --NH--(CH.sub.2).sub.m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar.sub.1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and trifluoromethyl; and R is represented by either hydrogen or a C.sub.1-4 alkyl; R.sub.1 is represented by hydrogen or a C.sub.1-4 alkyl; the optional isomers and tautomers thereof; and the pharmaceutically acceptable acid addition salts thereof, and their use as calcium antagonists.Type: GrantFiled: January 10, 1990Date of Patent: April 21, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Albert A. Carr, Hsien C. Cheng, John M. Kane
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Patent number: 5082837Abstract: Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activites associated with calcium antagonists.Type: GrantFiled: November 29, 1990Date of Patent: January 21, 1992Assignee: Merrell Dow PharmaceuticalsInventors: Michael G. Palfreyman, Norbert L. Wiech, Hsien C. Cheng, John M. Kane
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Patent number: 5010072Abstract: Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.Type: GrantFiled: June 28, 1988Date of Patent: April 23, 1991Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Norbert L. Wiech, Hsien C. Cheng, John M. Kane
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Patent number: 4999431Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.Type: GrantFiled: February 23, 1990Date of Patent: March 12, 1991Assignee: Merrell Dow PharmaceuticalsInventors: Winton D. Jones, Richard C. Dage, George P. Claxton, Hsien C. Cheng, Phillip J. Robinson
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Patent number: 4990519Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.Type: GrantFiled: February 23, 1990Date of Patent: February 5, 1991Assignee: Merrell Dow PharmaceuticalsInventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
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Patent number: 4908372Abstract: The present invention is directed to a new class of piperidinyl benzimidazole antihistamines which can be described by the following formula: ##STR1## wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy and hydrogen, X is represented by hydrogen, COOR.sub.2 in which R.sub.2 is represented by a C.sub.1-4 alkyl, or X is an alkylene phenyl radical of the formula: ##STR2## wherein T is represented by CHOH, CO, O, or a direct bond; R.sub.1 is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: October 13, 1988Date of Patent: March 13, 1990Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Albert A. Carr, Hsien C. Cheng, John M. Kane
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Patent number: 4886811Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.Type: GrantFiled: October 24, 1988Date of Patent: December 12, 1989Assignee: Merrell Dow PharmaceuticalsInventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson