Patents by Inventor Hsien C. Shih

Hsien C. Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inadone and tetralone compounds for inhibiting cell proliferation
    Patent number: 6162810
    Abstract: A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationary phase (non-dividing) malignant cells, yet do not impair the viability of normal nonproliferating cells; and, (2) they affect cells which have acquired MDR more powerfully than they affect cells without MDR. Thus, the TBs of the invention provide means to target malignant cells for chemotherapy, even after previous therapies have failed, without affecting normal cells and tissues in the host.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: December 19, 2000
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Hsien C. Shih, Howard B. Cottam, Lorenzo Leoni