Abstract: By regulating separation system's relative parameters, this broad and generalized separation process is disclosed to distinguish the fundament between this invention and chromatography for superior cost-effectiveness. A different mass transfer contacting method and differential set-up between two phases are applied on the disclosed apparatus to achieve purposed efficiency. This continuous separation process can be furnished as the integration of multiple partial fluidized beds or cells; operated under designated pressure level to instantaneous and simultaneous proceeding of determined mass-transfer phenomena. All zones within the process are simultaneously proceeded to isolate one product or multiple products from feed mixtures with other proceeding zones of feeding, impurity stripping, regeneration and washing. The differential mass transfer contact method is disclosed for efficient consumption of both solid phase and mobile phase.

Abstract: For sakes of eliminating displacement zone and fully utilizing the void volume in traditional chromatography, a separation process herein disclosed is for better efficiency in separation of mixed solution of glucose and fructose into glucose and fructose solution. More specifically, the process implements a new mass transfer method onto an alkaline-earth metal cation exchanger bed for proceeding like SMB process, yet, in a single bed or multiple beds in a bundle with batch operation mode. Said new method further integrates with differential set-up protocols between solid phase resin and a multiplicity of liquid mixtures, an operation protocol to implement all above indicated methods. By the virtue of said new mass transfer method and differential set-up, the process herein disclosed is capable of separation of glucose and fructose feed solution into 100% yield of respective pure component.

Abstract: By regulating separation system's relative parameters, this broad and generalized separation process is disclosed to distinguish the fundament between this invention and chromatography for superior cost-effectiveness. A different mass transfer contacting method and differential set-up between two phases are applied on the disclosed apparatus to achieve purposed efficiency. This continuous separation process can be furnished as the integration of multiple partial fluidized beds or cells; operated under designated pressure level to instantaneous and simultaneous proceeding of determined mass-transfer phenomena. All zones within the process are simultaneously proceeded to isolate one product or multiple products from feed mixtures with other proceeding zones of feeding, impurity stripping, regeneration and washing. The differential mass transfer contact method is disclosed for efficient consumption of both solid phase and mobile phase.

Abstract: The process implements a new mass transfer method by eliminating the displacement zone and fully utilizing the void volume in chromatography for proceeding prompt and efficient mass transfer proceeding between two phases. Said new method further integrates with a differential set-up protocols between solid phase resin and a multiplicity of liquid mixtures, an operation protocol, and an apparatus to implement all above indicated methods. By the virtue of said new mass transfer method and differential set-up, the process herein disclosed is capable of continuous separation of glucose and fructose feed solution into 100% yield of respective pure component. Said process is operated by simultaneously proceeding of feeding, fraction recovery, and enhancing concentration of separated fractions through a single stage recycle procedures. It cutbacks nearly 50% of resin stock compared under same feed throughput with SMB process that has separation of 88% recovery of 90% fructose purity in product stream.

Abstract: A continuous industrial separation process for biopolymer extracts each individual single component from a stream of cell extract. The process can be set up as a mixed flow reactor or fluidized bed in a continuous operation under normal pressure to treat a volume of cell extract in a short period of time. The separated single biopolymer is continuously withdrawn from the process and be easily condensed into the desired concentration. A resin, which can be an ion exchanger or affinity adsorbent or dye ligand adsorbent or hydrophobic adsorbent or immunoadsorbent, is evenly suspended in a well mixed reactor to equilibrate with the biopolymers in the liquid phase. The fundamental separation scheme is successive adsorption and desorption of biopolymer from liquid. Biopolymers are isolated into a single stream or multistreams for one component or many individual components. Each stream contains only one high purity biopolymer.