Patents by Inventor Hsieng Sen Lu

Hsieng Sen Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210040189
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Application
    Filed: September 9, 2020
    Publication date: February 11, 2021
    Applicant: AMGEN INC.
    Inventors: William Gleason RICHARDS, Hsieng Sen LU, Hua Zhu KE, Chaoyang LI, Frederick W. JACOBSEN
  • Patent number: 10800839
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: October 13, 2020
    Assignee: AMGEN INC.
    Inventors: William Gleason Richards, Hsieng Sen Lu, Hua Zhu Ke, Chaoyang Li, Frederick W. Jacobsen
  • Publication number: 20180142029
    Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 24, 2018
    Applicant: AMGEN INC.
    Inventors: Thomas C. BOONE, David W. BRANKOW, Colin V. GEGG, JR., Shaw-Fen Sylvia HU, Chadwick T. KING, Hsieng Sen LU, Licheng SHI, Cen XU
  • Publication number: 20180111985
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 26, 2018
    Applicant: Amgen Inc.
    Inventors: William Gleason RICHARDS, Hsieng Sen LU, Hua Zhu KE, Chaoyang LI, Frederick W. JACOBSEN
  • Patent number: 9879072
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: January 30, 2018
    Assignee: AMGEN INC.
    Inventors: William Gleason Richards, Hsieng Sen Lu, Hua Zhu Ke, Chaoyang Li, Frederick W. Jacobsen
  • Patent number: 9862771
    Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: January 9, 2018
    Assignee: AMGEN INC.
    Inventors: Thomas C. Boone, David W. Brankow, Colin V. Gegg, Jr., Shaw-Fen Sylvia Hu, Chadwick T. King, Hsieng Sen Lu, Licheng Shi, Cen Xu
  • Patent number: 9353174
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 31, 2016
    Assignee: AMGEN INC.
    Inventors: Christopher J. Paszty, Hsieng Sen Lu
  • Publication number: 20150376286
    Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
    Type: Application
    Filed: June 26, 2015
    Publication date: December 31, 2015
    Applicant: AMGEN INC.
    Inventors: Thomas C. BOONE, David W. BRANKOW, Colin V. GEGG, JR., Shaw-Fen Sylvia HU, Chadwick T. KING, Hsieng Sen LU, Licheng SHI, Cen XU
  • Publication number: 20150322144
    Abstract: There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them.
    Type: Application
    Filed: March 19, 2015
    Publication date: November 12, 2015
    Inventors: Huiquan Han, Taruna Arora, Qing Chen, Hsieng Sen Lu, Xiaolan Zhou
  • Patent number: 9102731
    Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 11, 2015
    Assignee: AMGEN INC.
    Inventors: Thomas C. Boone, David W. Brankow, Colin V. Gegg, Jr., Shaw-Fen Sylvia Hu, Chadwick T. King, Hsieng Sen Lu, Licheng Shi, Cen Xu
  • Patent number: 8999343
    Abstract: Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and methods of use.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: April 7, 2015
    Assignee: Amgen Inc.
    Inventors: Huiquan Han, Taruna Arora, Qing Chen, Hsieng Sen Lu, Xiaolan Zhou
  • Publication number: 20140248666
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: February 20, 2014
    Publication date: September 4, 2014
    Applicant: Amgen Inc.
    Inventors: Christopher J. Paszty, Hsieng Sen Lu
  • Patent number: 8715663
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 6, 2014
    Assignee: Amgen Inc.
    Inventors: Christopher J. Paszty, Hsieng Sen Lu
  • Publication number: 20130209489
    Abstract: There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60.
    Type: Application
    Filed: August 15, 2011
    Publication date: August 15, 2013
    Inventors: Huiquan Han, Taruna Arora, Qing Chen, Hsieng Sen Lu, Xiaolan Zhou
  • Publication number: 20130209475
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Application
    Filed: October 27, 2011
    Publication date: August 15, 2013
    Inventors: William Gleason Richards, Hsieng Sen Lu, Hua Zhu Ke, Chaoyang Li, Frederick W. Jacobsen
  • Publication number: 20130071410
    Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related, disorders including the treatment and/or prevention of migraine headaches.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 21, 2013
    Inventors: Thomas C. Boone, David W. Brankow, Colin V. Gegg, JR., Shaw-Fen Sylvia Hu, Chadwick T. King, Hsieng Sen Lu, Licheng Shi, Cen Xu
  • Publication number: 20120087912
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
    Type: Application
    Filed: December 12, 2011
    Publication date: April 12, 2012
    Applicant: AMGEN INC.
    Inventors: Ji Li, Wenyan Shen, Hsieng Sen Lu, William Gleason Richards
  • Patent number: 8101184
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: January 24, 2012
    Assignee: Amgen Inc.
    Inventors: Ji Li, Wenyan Shen, Hsieng Sen Lu, William Gleason Richards
  • Patent number: 8003108
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: August 23, 2011
    Assignees: Amgen Inc., UCB SA
    Inventors: Hsieng Sen Lu, Christpher Paszty, Martyn Kim Robinson, Alistair James Henry, Kelly Sue Warmington, John Latham, Alastair Lawson, David Winkler, Aaron George Winters
  • Patent number: 7794970
    Abstract: Methods for generating F(ab?)2 fragments from antibodies using thermolysin as well as F(ab?)2 fragments and compositions comprising F(ab?)2 fragments generated by the method are described.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: September 14, 2010
    Assignee: Amgen Inc.
    Inventors: John O. Hui, Mitsuru Haniu, Hsieng Sen Lu