Patents by Inventor HSIN-LIN LU

HSIN-LIN LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted integration sites in Chinese hamster ovary cell genome
    Patent number: 11499139
    Abstract: Described herein are specific CHO genomic sites for targeted insertion of exogenous genes. The sites are located within a sequence selected from SEQ ID NOs: 1-16.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 15, 2022
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Hsuan-Pu Chen, Hsin-Lin Lu, Chien-I Lin, Hsueh-Lin Lu, Tao-Tien Chen
  • TARGETED INTEGRATION SITES IN CHINESE HAMSTER OVARY CELL GENOME
    Publication number: 20200157509
    Abstract: Described herein are specific CHO genomic sites for targeted insertion of exogenous genes. The sites are located within a sequence selected from SEQ ID NOs: 1-16.
    Type: Application
    Filed: December 19, 2017
    Publication date: May 21, 2020
    Inventors: Hsuan-Pu CHEN, Hsin-Lin LU, Chien-I LIN, Hsueh-Lin LU, Tao-Tien CHEN
  • HOST CELLS WITH ENHANCED PROTEIN EXPRESSION EFFICIENCY AND USES THEREOF
    Publication number: 20190194686
    Abstract: A host cell for protein expression having a lower expression level of a gene, as compared to a wild-type cell, wherein the gene is selected from HDAC8, Dab2, Caspase3, Sys1, Ergic3, Grasp, Trim 23, or a combination thereof. The host cells are CHO cells. The lower expression level of the gene results from RNA interference, which may be achieved by transfecting a vector that contains an shRNA targeting the gene.
    Type: Application
    Filed: September 29, 2018
    Publication date: June 27, 2019
    Applicant: Development Center for Biotechnology
    Inventors: HSIN-LIN LU, CHIEN-I LIN, CHAO-YI TENG