Abstract: Provided is a pharmaceutical composition for delivery of an active agent to an eye. The pharmaceutical composition may comprise a lipid mixture; an active agent and a biocompatible hydrogel. The pharmaceutical composition achieves a prolonged therapeutic effect as well as reduced side effects. Also provided is a method of delivering an active agent in the pharmaceutical composition to an eye of a subject in need thereof.

Abstract: A method includes forming a dielectric layer over a contact pad of a device, forming a first polymer layer over the dielectric layer, forming a first conductive line and a first portion of a second conductive line over the first polymer layer, patterning a photoresist to form an opening over the first portion of the second conductive feature, wherein after patterning the photoresist the first conductive line remains covered by photoresist, forming a second portion of the second conductive line in the opening, wherein the second portion of the second conductive line physically contacts the first portion of the second conductive line, and forming a second polymer layer extending completely over the first conductive line and the second portion of the second conductive line.

Abstract: Crystalline 4-((L-valyl)oxy)butanoic acid, methods of preparing crystalline 4-((L-valyl)oxy)butanoic acid, pharmaceutical compositions of crystalline 4-((L-valyl)oxy)butanoic acid, and methods of treatment using crystalline 4-((L-valyl)oxy)butanoic acid are disclosed.

Abstract: A recuperated gas turbine engine. The gas turbine engine includes a heat exchanger, and gas turbine (including compressor, can-type combustor and turbine). The heat exchanger includes a compressed air passageway and a turbine exhaust gas passageway adjacent to each other within the casing which extend spirally throughout the heat exchanger and towards an inner cylindrical chamber in which the combustor is positioned approximately to the center of the casing. Improved engine fuel efficiency is achieved by preheating the compressed air before it reaches the combustor with the higher-temperature exhaust gas. A can-type combustor is used for alleviating heat-dissipation issues to improve efficiency of the combustion. A concentric back-to-back rotor arrangement significantly shortens the length of a conventional engine turbine rotor which improves on the operational stability of a gas turbine engine.

Abstract: A recuperated gas turbine engine is disclosed, comprising: a heat exchanger, and gas turbine (including compressor, can-type combustor and turbine); wherein, said heat exchanger comprises a compressed air passageway and a turbine exhaust gas passageway adjacent to each other within the casing which extend spirally throughout said heat exchanger and towards an inner cylindrical chamber in which said combustor is positioned approximately to the center of said casing. Improved engine fuel efficiency is achieved by preheating the compressed air before it reaches the combustor with the higher-temperature exhaust gas. A can-type combustor is used for alleviating heat-dissipation issues to improve efficiency of the combustion. A concentric back-to-back rotor arrangement significantly shortens the length of a conventional engine turbine rotor which improves on the operational stability of a gas turbine engine.