Patents by Inventor Hsing-Pang Hsieh
Hsing-Pang Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090149545Abstract: A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin, sanguinarine, amiodarone, chlorpromazine, clomiphene, dihydroergotamine, dipyridamole, emetine, ephedrine, prochlorperazine, promazine, propiomazine, aminacrine, fluphenazine, fenoterol, peruvoside, proglumide, atenolol, nerifolin, nefopam, cycloheximide, avermectin B1, bepridil, cinnarizine, ethisterone, pararosaniline, methylbenzethonium, niclosamide, pipobroman, homidium, calcimycin, anisomycin, metergoline, amodiaquine, danazol, danthron, ethopropazine, eucatropine, nortriptyline, resorcinol, mebhydrolin, mebeverine, trimipramine, triflupromazine, chlorprothixene, cyclobenzaprine, enoxacin, sulfanitran, monensin, nigericin, perphenazine, methoxamine, astemizole, trifluoperazine, acriflavinium, rotenone, acebutolol, quabain, methiothepin, convallatoxin, halcinonide, cyclosporin, pimethixene, mycophenolic acid, promethazine, mesoridazine,Type: ApplicationFiled: May 28, 2004Publication date: June 11, 2009Inventors: Tsu-An Hsu, Hsing-Pang Hsieh, Yu-Sheng Chao, Chi-Min Chen, Jia-Tsrong Jan, Hwan-Wun Liu
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Patent number: 7544712Abstract: A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin, sanguinarine, amiodarone, chlorpromazine, clomiphene, dihydroergotamine, dipyridamole, emetine, ephedrine, prochlorperazine, promazine, propiomazine, aminacrine, fluphenazine, fenoterol, peruvoside, proglumide, atenolol, nerifolin, nefopam, cycloheximide, avermectin B1, bepridil, cinnarizine, ethisterone, pararosaniline, methylbenzethonium, niclosamide, pipobroman, homidium, calcimycin, anisomycin, metergoline, amodiaquine, danazol, danthron, ethopropazine, eucatropine, nortriptyline, resorcinol, mebhydrolin, mebeverine, trimipramine, triflupromazine, chlorprothixene, cyclobenzaprine, enoxacin, sulfanitran, monensin, nigericin, perphenazine, methoxamine, astemizole, trifluoperazine, acriflavinium, rotenone, acebutolol, quabain, methiothepin, convallatoxin, halcinonide, cyclosporin, pimethixene, mycophenolic acid, promethazine, mesoridazine,Type: GrantFiled: May 28, 2004Date of Patent: June 9, 2009Assignee: National Health Research InsitutesInventors: Tsu-An Hsu, Hsing-Pang Hsieh, Yu-Sheng Chao, Chi-Min Chen, Jia-Tsrong Jan, Hwan-Wun Liu
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Patent number: 7528165Abstract: This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein.Type: GrantFiled: August 1, 2005Date of Patent: May 5, 2009Assignee: National Health Research InstitutesInventors: Hsing-Pang Hsieh, Jing-Ping Liou, Jang-Yang Chang, Chun-Wei Chang
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Publication number: 20090111876Abstract: This invention relates to an extract of Chlorella sorokiniana, which contains myristic acid, palmitic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, and stearic acid. Also related is use of this extract to treat diabetes, obesity, and dyslipidaemia.Type: ApplicationFiled: October 16, 2008Publication date: April 30, 2009Applicant: International Chlorella Co. Ltd.Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Yu-Sheng Chao, Yu-Cheng Chou, Shun Te Wang
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Patent number: 7456289Abstract: Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder with one of these compounds.Type: GrantFiled: December 15, 2005Date of Patent: November 25, 2008Assignee: National Health Research InstitutesInventors: Hsing-Pang Hsieh, Yu-Sheng Chao, Jing-Ping Liou, Jang-Yang Chang, Yen-Shih Tung
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Patent number: 7449478Abstract: This invention relates to treating peroxisome proliferator-activated receptors related diseases with certain indole compounds. The indole compounds are of formula (I) below. Each variable is defined in the specification.Type: GrantFiled: December 3, 2004Date of Patent: November 11, 2008Assignee: National Health Research InstitutesInventors: Hsing-Pang Hsieh, Neeraj Mahindroo, Tsu-An Hsu, Chien-Fu Huang, Xin Chen, Yu-Sheng Chao
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Patent number: 7425633Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting dipeptidyl peptidase IV or for treating Type II diabetes with such a compound.Type: GrantFiled: August 28, 2006Date of Patent: September 16, 2008Assignee: National Health Research InstitutesInventors: Weir-Torn Jiaang, Yu-Sheng Chao, Hsing-Pang Hsieh
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Publication number: 20080058386Abstract: A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O), or R?—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R? and R? independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3 is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.Type: ApplicationFiled: May 10, 2007Publication date: March 6, 2008Applicants: Taipei Medical University, National Health Research InstitutesInventors: Jing-Ping Liou, Jang-Yang Chang, Hsing-Pang Hsieh
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Publication number: 20070082932Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting dipeptidyl peptidase IV or for treating Type II diabetes with such a compound.Type: ApplicationFiled: August 28, 2006Publication date: April 12, 2007Inventors: Weir-Torn Jiaang, Yu-Sheng Chao, Hsing-Pang Hsieh
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Publication number: 20060148801Abstract: Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and ---- are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder with one of these compounds.Type: ApplicationFiled: December 15, 2005Publication date: July 6, 2006Inventors: Hsing-Pang Hsieh, Yu-Sheng Chao, Jing-Ping Liou, Jang-Yang Chang, Yen-Shih Tung
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Publication number: 20060019967Abstract: This invention relates to a method for modulating activity of SARS CoV main protease or an analogue thereof by contacting the protein with an effective amount of a compound of the following formula: A1-L-A2 wherein A1, A2, and L are defined herein, and use of the compound in treating coronavirus infection, hepatitis C virus infection, hemophilia, vascular restenosis, or hypertension.Type: ApplicationFiled: July 20, 2005Publication date: January 26, 2006Inventors: Su-Ying Wu, Hsing-Pang Hsieh, Tsu-An Hsu, I-Lin Lu
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Publication number: 20050267108Abstract: This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein.Type: ApplicationFiled: August 1, 2005Publication date: December 1, 2005Inventors: Hsing-Pang Hsieh, Jing-Ping Liou, Jang-Yang Chang, Chun-Wei Chang
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Publication number: 20050267194Abstract: Indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein. Also disclosed are methods of using of the indole compounds in inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders.Type: ApplicationFiled: August 1, 2005Publication date: December 1, 2005Inventors: Hsing-Pang Hsieh, Jing-Ping Liou, Jang-Yang Chang, Chun-Wei Chang
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Publication number: 20050222222Abstract: A compound of the following formula: wherein R1 R2, R3, R4, R5, R6, W, X, Y, Z, m, n, and p are as defined herein. This invention also covers methods for inhibiting dipeptidyl peptidase IV or VIII, or treating Type II diabetes with such a compound.Type: ApplicationFiled: March 9, 2005Publication date: October 6, 2005Inventors: Weir-Torn Jiaang, Xin Chen, Su-Ying Wu, Yu-Sheng Chao, Hsing-Pang Hsieh
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Patent number: 6933316Abstract: Indole compounds of the formula: wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR?, SO2R, SO3R, SO2NRR?, SR, NRR?, NRSO2NR?R?, NRSO2R?, NRSO3R?, NRC(O)R?, NRC(O)NR?R?, NRC(O)OR?, NRC(N)NR?R?, C(O)OR, or C(O)NRR?; each of Ra, Rb, Rc, and Rd, independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR?, SO2R, SO3R, SO2NRR?, SR, NRR?, NRSO2NR?R?, NRSO2R?, NRSO3R?, NRC(O)R?, NRC(O)NR?R?, NRC(O)OR?, NRC(N)NR?R?, C(O)R, C(O)OR, C(O)NRR?, or Rb and Rc, Ra and Rb, or Rc and Rd taken together are O(CH2)nO; and Rc is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR?, SO2R, SO3R, SO2NRR?, SR, NRR?, NRSO2NR?R?, NRSO2R?, NRSO3R?, NRC(O)R?, NRC(O)NR?R?, NRC(O)OR?, NRC(N)NR?R?, C(O)R, C(O)OR, or C(O)NRR?; in which each of R, R?, and R?, independently, is H, alkyl, alkenyl, alkyType: GrantFiled: December 12, 2002Date of Patent: August 23, 2005Assignee: National Health Research InstitutesInventors: Hsing-Pang Hsieh, Jing-Ping Liou, Jang-Yang Chang, Chun-Wei Chang
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Publication number: 20050124675Abstract: This invention relates to treating peroxisome proliferator-activated receptors related diseases with certain indole compounds. The indole compounds are of formula (I) below. Each variable is defined in the specification.Type: ApplicationFiled: December 3, 2004Publication date: June 9, 2005Inventors: Hsing-Pang Hsieh, Neeraj Mahindroo, Tsu-An Hsu, Chien-Fu Huang, Xin Chen, Yu-Sheng Chao
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Publication number: 20040229936Abstract: This invention relates to a method for treating HCV infection. The method includes administering to a subject in need thereof an effective amount of one or more of sesquiterpene lactones having a &ggr;-lactone fused with a 10-membered ring, an 8-membered ring that is further fused with a 4-membered ring, a 7-membered ring that is further fused with a 5-membered ring, or a 6-membered ring that is further fused with a 6-membered ring.Type: ApplicationFiled: April 2, 2004Publication date: November 18, 2004Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Der-Ren Hwang
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Publication number: 20040044069Abstract: This invention features a method for treating infection by herpesvirus.Type: ApplicationFiled: May 23, 2003Publication date: March 4, 2004Inventors: Tsu-An Hsu, Hsing-Pang Hsieh, Li-Jung Juan, Sui-Yuan Chang, Yueh-Hsiung Kuo
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Publication number: 20030195244Abstract: Indole compounds of the formula: 1Type: ApplicationFiled: December 12, 2002Publication date: October 16, 2003Inventors: Hsing-Pang Hsieh, Jing-Ping Liou, Jang-Yang Chang, Chun-Wei Chang
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Patent number: 5610149Abstract: New steroidal polyamines have the structure of formula I or formula II: ##STR1## wherein R.sub.1 and R.sub.2 are independently N(R').sub.3.sup.+ or H in the .alpha.- or .beta.- position except both R.sub.1 and R.sub.2 are not H;R.sub.3 is N(R').sub.3.sup.+ in the .alpha.- position or hydrogenR.sub.4 is OH, N(R').sub.3, or NHC(NH.sub.2)NH.sub.2.sup.+R' is hydrogen, alkyl of one to four carbons, aralkyl, or combinations thereof.Type: GrantFiled: May 12, 1995Date of Patent: March 11, 1997Assignee: The Research Foundation of State University of New YorkInventors: Cynthia J. Burrows, Hsing-Pang Hsieh