Abstract: A heat exchange cooling structure includes a LED module, a heat spreader plate bonded to the bottom surface of the substrate of the LED module, and an electronic ceramic cooling plate made of a nano-scale inorganic semiconductor material through a sintering process and bonded to the bottom side of the heat spreader plate for dissipating heat from the heat spreader plate by means of a thermoelectric effect produced in millions of parallel-connected and series-connected N-P interfaces in the nano-scale inorganic semiconductor material.