Patents by Inventor Hsing-Ying Lin
Hsing-Ying Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11125745Abstract: Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the potentiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate.Type: GrantFiled: January 27, 2017Date of Patent: September 21, 2021Assignees: The General Hospital Corporation, The Brigham and Women's Hospital, Inc.Inventors: Hakho Lee, Ralph Weissleder, Sangmoo Jeong, Jongmin Park, Cesar Castro, Hsing-Ying Lin, Jamil Azzi
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Patent number: 10975105Abstract: The present invention provides a composition for substrate surface modification and a method using the same, and the composition for substrate surface modification is composed of a compound of the general formula structure shown in formula 1: wherein n1 is an integer of 1 to 6, and R is a zwitterionic group. The composition for substrate surface modification uses water as a medium to perform modifying reaction over a substrate surface, and at the same time has biological modification characteristics, and abilities of immobilizing biomolecules and anti-biofouling.Type: GrantFiled: August 5, 2019Date of Patent: April 13, 2021Assignee: NATIONAL CENTRAL UNIVERSITYInventors: Chen-Han Huang, Wen-Hao Chen, Hsing-Ying Lin
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Publication number: 20200048283Abstract: The present invention provides a composition for substrate surface modification and a method using the same, and the composition for substrate surface modification is composed of a compound of the general formula structure shown in formula 1: wherein n1 is an integer of 1 to 6, and R is a zwitterionic group. The composition for substrate surface modification uses water as a medium to perform modifying reaction over a substrate surface, and at the same time has biological modification characteristics, and abilities of immobilizing biomolecules and anti-biofouling.Type: ApplicationFiled: August 5, 2019Publication date: February 13, 2020Inventors: Chen-Han HUANG, Wen-Hao CHEN, Hsing-Ying LIN
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Publication number: 20190346434Abstract: Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the potentiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate.Type: ApplicationFiled: January 27, 2017Publication date: November 14, 2019Inventors: Hakho Lee, Ralph Weissleder, Sangmoo Jeong, Jongmin Park, Caesar Castro, Hsing-Ying Lin, Jamil Azzi
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Patent number: 9829437Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.Type: GrantFiled: May 18, 2015Date of Patent: November 28, 2017Assignee: NATIONAL CHUNG CHENG UNIVERSITYInventors: Lai-Kwan Chau, Hsing-Ying Lin, Chen-Han Huang, Ling-Hsuan Liu, Wen-Hsin Hsieh
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Publication number: 20160139052Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.Type: ApplicationFiled: May 18, 2015Publication date: May 19, 2016Inventors: LAI-KWAN CHAU, HSING-YING LIN, CHEN-HAN HUANG, LING-HSUAN LIU, WEN-HSIN HSIEH
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Patent number: 9061083Abstract: The invention relates to an ultraviolet laser sterilization system, comprising an ultraviolet laser module and a scanning module. The ultraviolet laser module emits an ultraviolet laser light with a wavelength ranging from 200 nm to 280 nm. The scanning module includes a plurality of reflectors for receiving the ultraviolet laser light, and a controller for controlling rotation of the reflectors to adjust an angle of emergence of the ultraviolet laser light for sterilizing a target.Type: GrantFiled: January 7, 2014Date of Patent: June 23, 2015Assignee: National Cheng Kung UniversityInventors: Hsiang-Chen Chui, Sean Sung-Yen Juang, Hsing-Ying Lin, Chen-Han Huang, Hua-Hsien Liao
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Publication number: 20150048260Abstract: The invention relates to an ultraviolet laser sterilization system, comprising an ultraviolet laser module and a scanning module. The ultraviolet laser module emits an ultraviolet laser light with a wavelength ranging from 200 nm to 280 nm. The scanning module includes a plurality of reflectors for receiving the ultraviolet laser light, and a controller for controlling rotation of the reflectors to adjust an angle of emergence of the ultraviolet laser light for sterilizing a target.Type: ApplicationFiled: January 7, 2014Publication date: February 19, 2015Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: HSIANG-CHEN CHUI, SEAN SUNG-YEN JUANG, HSING-YING LIN, CHEN-HAN HUANG, HUA-HSIEN LIAO
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Patent number: 8902420Abstract: The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.Type: GrantFiled: December 27, 2011Date of Patent: December 2, 2014Assignee: National Cheng Kung UniversityInventors: Yon-Hua Tzeng, Chih-Yi Liu, Chen-Han Huang, Hsing-Ying Lin, Hsiang-Chen Chui, Kyaw-Oo Lau, Shih-Tse Chen, Cheng-Wen Huang
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Patent number: 8461511Abstract: A photo-sensitive composite film is disclosed, which includes plural metal nano-particles and a porous anodized aluminum oxide film. The nanoparticles can be hollow or solid with unrestricted shapes of varying diameters and lengths. The plural metal nanoparticles are completely contained in holes and attached to the bottom of the holes of the anodized aluminum oxide film, and the electrical conductivity of the photo-sensitive anodized aluminum oxide film can be changed by light exposure on the metal nanoparticles from surfaces of the anodized aluminum oxide film. The structure of the photo-sensitive anodized aluminum oxide film of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the photo-sensitive anodized aluminum oxide film of the present invention is of great commercial value. Also, a method of manufacturing the above photo-sensitive composite film and a photo-switched device including the same are disclosed.Type: GrantFiled: August 15, 2011Date of Patent: June 11, 2013Assignee: National Cheng Kung UniversityInventors: Yon-Hua Tzeng, Chih-Yi Liu, Kyaw-Oo Kyaw, Hsiang-Chen Chui, Chen-Han Huang, Hsing-Ying Lin
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Publication number: 20120194813Abstract: The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.Type: ApplicationFiled: December 27, 2011Publication date: August 2, 2012Applicant: National Cheng Kung UniversityInventors: Yon-Hua TZENG, Chih-Yi Liu, Chen-Han Huang, Hsing-Ying Lin, Hsiang-Chen Chui, Kyaw-Oo Lau, Shih-Tse Chen, Cheng-Wen Huang
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Publication number: 20120037792Abstract: A photo-sensitive composite film is disclosed, which includes plural metal nano-particles and a porous anodized aluminum oxide film. The nanoparticles can be hollow or solid with unrestricted shapes of varying diameters and lengths. The plural metal nanoparticles are completely contained in holes and attached to the bottom of the holes of the anodized aluminum oxide film, and the electrical conductivity of the photo-sensitive anodized aluminum oxide film can be changed by light exposure on the metal nanoparticles from surfaces of the anodized aluminum oxide film. The structure of the photo-sensitive anodized aluminum oxide film of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the photo-sensitive anodized aluminum oxide film of the present invention is of great commercial value. Also, a method of manufacturing the above photo-sensitive composite film and a photo-switched device including the same are disclosed.Type: ApplicationFiled: August 15, 2011Publication date: February 16, 2012Applicant: National Cheng Kung UniversityInventors: Yon-Hua TZENG, Chih-Yi Liu, Kyaw-Oo Kyaw, Hsiang-Chen Chui, Chen-Han Huang, Hsing-Ying Lin
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Publication number: 20040249616Abstract: A resource modeler system comprises a processor adapted to receive a desired time period for completing a processing task and a library having information associated with a plurality of processor speeds. The system also comprises a modeler adapted to determine a quantity of cycles for each of the processor speeds corresponding to the desired time period and a quantity of cycles for each of the processor speeds corresponding to completion of the processing task. The modeler is further adapted to compare the determined quantities of cycles to select one of the plurality of processor speeds for completing the processing task within the desired time period.Type: ApplicationFiled: April 16, 2003Publication date: December 9, 2004Inventors: Stephanie A. Vierus, John A. Hall, David J. Irish, Hsing-Ying Lin