Abstract: Provided is a method for diagnosing and monitoring progression of cancer or effectiveness of a therapeutic treatment. The method includes detecting a methylation level of at least one gene in a biological sample containing circulating free DNA. Also provided are primer pairs and probes for diagnosis or prognosis of cancer in a subject in need thereof.

Abstract: An itinerary planning system and method applicable to data processing systems is proposed, comprising: a database having travel information and itinerary planning conditions; a setting module for receiving information on itinerary planning conditions set by the user; a searching module for retrieving from the database the travel information that corresponds to itinerary planning conditions set by the user; and a planning module for creating an itinerary based on itinerary planning conditions and the correspondent travel information retrieved from the database, thereby building an itinerary from the database according to itinerary planning conditions set by the user.