Patents by Inventor Hsiu-Man Lien

Hsiu-Man Lien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11883418
    Abstract: A compound TSYI-ZAC (Zhankuic acid C) used in a method for treating dengue virus infection, in which a pharmaceutical composition can further comprise a 4,7-dimethoxy-5-methyl-1,3-benzodioxole compound capable of inhibiting dengue virus infection by down-regulating an expression of IL-6 and IL-8, and increasing a secretion of IFN-?.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: January 30, 2024
    Assignee: SYI BIOTECHNOLOGY CO., LTD.
    Inventors: Chia-Chang Chen, Guey-Chuen Perng, Hsiu-Man Lien, Yi-Ju Chen
  • Publication number: 20230285415
    Abstract: A compound TSYI-ZAC (Zhankuic acid C) used in a method for treating dengue virus infection, in which a pharmaceutical composition can further comprise a 4,7-dimethoxy-5-methyl-1,3-benzodioxole compound capable of inhibiting dengue virus infection by down-regulating an expression of IL-6 and IL-8, and increasing a secretion of IFN-?.
    Type: Application
    Filed: June 8, 2022
    Publication date: September 14, 2023
    Inventors: Chia-Chang Chen, Guey-Chuen Perng, Hsiu-Man Lien, Yi-Ju Chen
  • Publication number: 20230233629
    Abstract: A method to treat hepatoma with dengue viruses which infect liver tumor stem cells for annihilation of hepatocellular carcinoma tissues. The liver tumor stem cells expressing the biomarker of CD133 in a tumor part are the objects infected by dengue viruses preferentially and killed due to specific protein expressions for suppression of hepatoma.
    Type: Application
    Filed: July 22, 2022
    Publication date: July 27, 2023
    Inventors: Chia-Chang Chen, Guey-Chuen Perng, Hsiu-Man Lien, Yi-Ju Chen
  • Patent number: 11179431
    Abstract: Present invention provides a bioactive fraction of Anisomeles indica, TSYI-813, and its preparation which includes extracting Anisomeles indica using an alcohol solvent, fractioning the extract of Anisomeles indica by an organic solvent and water, and purifying via a silica column chromatography with 10:1˜10:5 hexane/ethyl acetate for sequential elution to give the bioactive fraction of Anisomeles indica, TSYI-813. The bioactive fraction of Anisomeles indica, TSYI-813, disclosed in present invention can can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: November 23, 2021
    Assignee: SYI BIOTECHNOLOGY CO., LTD.
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Sheau-Jiun Chang, Chao-Lu Huang
  • Publication number: 20210205392
    Abstract: Present invention provides an Anisomeles indica extract comprising ovatodiolide, apigenin-7-glucuronide, acteoside or scutellarin which can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.
    Type: Application
    Filed: December 29, 2020
    Publication date: July 8, 2021
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Chao-Lu Huang
  • Publication number: 20210205391
    Abstract: Present invention provides a bioactive fraction of Anisomeles indica, TSYI-813, and its preparation which includes extracting Anisomeles indica using an alcohol solvent, fractioning the extract of Anisomeles indica by an organic solvent and water, and purifying via a silica column chromatography with 10:1˜10:5 hexane/ethyl acetate for sequential elution to give the bioactive fraction of Anisomeles indica, TSYI-813. The bioactive fraction of Anisomeles indica, TSYI-813, disclosed in present invention can can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.
    Type: Application
    Filed: February 26, 2020
    Publication date: July 8, 2021
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Sheau-Jiun Chang, Chao-Lu Huang
  • Publication number: 20190358198
    Abstract: A use of ovatodiolide for preparing a composition used for inhibiting protein synthesis of gastric Helicobacter pylori, wherein the ovatodiolide achieves an effect of inhibiting gastric Helicobacter pylori by inhibiting the expression of 30S ribosomes RpsB of gastric Helicobacter pylori and further inhibiting its protein synthesis.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 28, 2019
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Chih-Ho Lai, Sheau-Jiun Chang, Hui-Yu Wu
  • Publication number: 20190209638
    Abstract: A natural composition that includes C. osmophloeum and C. pinnatifida. The C. osmophloeum is an aqueous extract of Cinnamomum osmophloeum leaves. The Crataegus pinnatifida is an aqueous extract of C. pinnatifida fruit. The weight ratio of the C. osmophloeum to the C. pinnatifida is 1:0.05-2, the preferred ratio is 1:0.5-1.5, and the optimal ratio is 1:0.9-1.1. The pharmaceutical composition has an ?-glucosidase inhibition effect. The natural composition can further inhibit ?-amylase to regulate the absorption of blood glucose and carbohydrate.
    Type: Application
    Filed: January 5, 2018
    Publication date: July 11, 2019
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Sheau-Jiun Chang, Chao-Lu Huang, Jui-Ting Hsu
  • Patent number: 9480722
    Abstract: A composition for use in inhibiting or killing Porphyromonas gingivalis, comprising an effective amount of Antrodia camphorata powder or extract and acceptable carriers thereof for inhibiting or killing Porphyromonas gingivalis. Also provided is a method of inhibiting or killing Porphyromonas gingivalis by using aforementioned composition. Further provided is a method of alleviating or treating diseases derived from Porphyromonas gingivalis by administrating a therapeutically effective amount of aforementioned composition. The Antrodia camphorata extract in accordance with the present invention have been proved having the efficacy of inhibiting or killing Porphyromonas gingivalis, and thus can be easily applied to various fields, particularly, health foods, drinks and applications of daily supplies. Moreover, advantages in accordance with the present invention include no side effects, easy fabricating and low cost.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: November 1, 2016
    Assignee: Yushen Biotechnology & Medical Co., Ltd.
    Inventors: Hsiu-Man Lien, Chia-Chang Chen, Chin-Jui Tseng
  • Publication number: 20130189296
    Abstract: A composition for use in inhibiting or killing Porphyromonas gingivalis, comprising an effective amount of Antrodia camphorata powder or extract and acceptable carriers thereof for inhibiting or killing Porphyromonas gingivalis. Also provided is a method of inhibiting or killing Porphyromonas gingivalis by using aforementioned composition. Further provided is a method of alleviating or treating diseases derived from Porphyromonas gingivalis by administrating a therapeutically effective amount of aforementioned composition. The Antrodia camphorata extract in accordance with the present invention have been proved having the efficacy of inhibiting or killing Porphyromonas gingivalis, and thus can be easily applied to various fields, particularly, health foods, drinks and applications of daily supplies. Moreover, advantages in accordance with the present invention include no side effects, easy fabricating and low cost.
    Type: Application
    Filed: March 5, 2012
    Publication date: July 25, 2013
    Applicant: YUSHEN BIOTECHNOLOGY & MEDICAL CO., LTD.
    Inventors: HSIU-MAN LIEN, Chia-Chang Chen, Chin-Jui Tseng
  • Publication number: 20110319485
    Abstract: The present invention provides a composition having anti-Helicobacter pylori activity and the composition contains ovatodiolide with effective dosage to inhibit Helicobacter pylori growth or ovatodiolide related substances and its acceptable carrier. The present invention also provides a method for treating ovatodiolide to produce a composition for killing Helicobacter pylori. The present invention also provides an application of ovatodiolide to produce pharmaceuticals for curing gastric ulcers. The ovatodiolide isolated from natural material extract has been confirmed able to inhibit the growth of Helicobacter pylori or to kill Helicobacter pylori. The ovatodiolide can be used in various industries related to the inhibiting or killing of Helicobacter pylori with few side effects and is easy to obtain with low cost.
    Type: Application
    Filed: April 29, 2011
    Publication date: December 29, 2011
    Applicant: Yushen Biotechnology & Medical Co, Ltd.
    Inventors: Hsiu-Man Lien, Chin-Jui Tseng, Ya-Yun Lai, Chao-Lu Huang, Chia-Chang Chen