Patents by Inventor Hsiu-Ming Shih

Hsiu-Ming Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USP37 inactivation as a treatment for PLZF/RARA-associated acute promyelocytic leukemia
    Patent number: 9353422
    Abstract: Method of regulating the stability and/or the level of the fusion protein PLZF/RARA are disclosed. Also disclosed are methods for identifying an agent as a regulator of the stability and/or the level of the fusion protein PLZF/RARA. Methods for identifying a therapeutic agent for treating PLZF/RARA-associated acute promyelocytic leukemia (APL) is also disclosed.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: May 31, 2016
    Assignee: ACADEMIA SINICA
    Inventors: Hsiu-Ming Shih, Wei-Chih Yang
  • USP37 INACTIVATION AS A TREATMENT FOR PLZF/RARA-ASSOCIATED ACUTE PROMYELOCYTIC LEUKEMIA
    Publication number: 20150148403
    Abstract: Method of regulating the stability and/or the level of the fusion protein PLZF/RARA are disclosed. Also disclosed are methods for identifying an agent as a regulator of the stability and/or the level of the fusion protein PLZF/RARA. Methods for identifying a therapeutic agent for treating PLZF/RARA-associated acute promyelocytic leukemia (APL) is also disclosed.
    Type: Application
    Filed: May 31, 2013
    Publication date: May 28, 2015
    Applicant: Academia Sinica
    Inventors: Hsiu-Ming Shih, Wei-Chih Yang
  • Split-hybrid system
    Publication number: 20030219831
    Abstract: A split-hybrid system that contains a nucleic acid including a promoter, a transcriptional regulatory sequence operably linked to the promoter and having a protein-binding domain, and a reporter gene operably linked to the promoter; a first recombinant polypeptide including a DNA-binding domain that binds to the protein-binding domain and a bait polypeptide; and a second recombinant polypeptide including a transcriptional repression domain and a prey polypeptide that interacts with the bait polypeptide. Interaction between the bait and prey polypeptides represses the expression of the reporter gene, and disruption of the interaction between the bait and prey polypeptides activates the expression of the reporter gene.
    Type: Application
    Filed: May 23, 2003
    Publication date: November 27, 2003
    Inventor: Hsiu-Ming Shih