Abstract: The present invention discloses an automatic stock and requisition administration system and method for medical and nursing application. The system comprises a cloud platform, at least one intelligent handheld device, and at least one automatic material supply machine. The automatic material supply machine links to the cloud platform through a network. The cloud platform generates requisition forms automatically according to nursing requirements or physician orders and provides the requisition forms for the automatic material supply machine and the intelligent handheld devices according to nursing schedules in user information. The users confirmed by a user recognition process can fast pick required materials from the automatic material supply machine in correct types and quantities. The information of the picked materials is transmitted to the cloud platform, and the cloud platform undertakes statistics and administration of materials.