Patents by Inventor Hua Gao

Hua Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11077130
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 3, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • Patent number: 11040091
    Abstract: The invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient having or at risk of having heart disease or heart failure, or decreased cardiac function, comprising: providing a cyclic adenosine monophosphate-incompetent (cAMP-incompetent) adenylyl cyclase type 6 (AC6) protein or polypeptide (also called “an AC6mut”), or an AC6mut-encoding nucleic acid or a gene operatively linked to a transcriptional regulatory sequence.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: H. Kirk Hammond, Mei Hua Gao
  • Patent number: 11030074
    Abstract: A method and associated computer system. A first machine executes machine code in a debugging session on the first machine. The machine code had been previously received by the first machine from a second machine. The machine code includes machine executable instructions. The machine code was generated from compilation of source code developed and compiled on the second machine. In response to a change in the machine code having detected by the first machine in the debugging session on the first machine, the first machine determines a portion of the source code associated with the change in the machine code based on a profile. The profile indicates a mapping between the source code and the machine code. The first machine, while communicating with the second machine, causes the portion of the source code to be updated on the second machine based on the change in the machine code.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: June 8, 2021
    Assignee: International Business Machines Corporation
    Inventors: Jun Hua Gao, Cheng Fang Wang, Xue Yong Zhang, Xi Bo Zhu
  • Publication number: 20210167870
    Abstract: Provided are a method, apparatus and system for measuring total radiated power of an array antenna. The method includes: determining a Rayleigh resolution of the array antenna in an angle space, and setting a stepping grid spacing of sampling points according to the Rayleigh resolution; determining the sampling points according to the stepping grid spacing, measuring equivalent isotropic radiated power (EIRP) at positions of the sampling points, and determining the TRP according to the EIRP. Compared with a traditional test mode using an angle stepping grid ?grid and ?grid of 15°, this reduces measurement errors; and additionally, through a normalized wave vector space transformation, the number of sampling points is further reduced, and the measurement efficiency is improved.
    Type: Application
    Filed: November 5, 2020
    Publication date: June 3, 2021
    Applicant: ZTE Corporation
    Inventors: Yanchun ZHUANG, Hua GAO, Kunjing ZHONG, Fei XUE
  • Patent number: 10918738
    Abstract: In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained therein a paracrine-encoding nucleic acid or gene, and the expression vehicle, vector, recombinant virus, or equivalent can express the paracrine-encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence, or the expression vehicle, vector, recombinant virus, or equivalent, to an individual or a patient in need thereof, thereby treating, ameliorating or protecting (preventing) the individual or patient a
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 16, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: H. Kirk Hammond, Mei Hua Gao
  • Publication number: 20200327136
    Abstract: An automated predictive analytics system disclosed herein provides a novel technique for industry classification. In one implementation, the analytic system provides a method of matching company names, the method including generating a provider-side company dataset, for each record in a client's company records, identify a list of match candidates from the provider-side company dataset that has overlapping company signature fragments, for each client-side company, compute match scores against the list of provider-side match candidates on each signature fragment and form an overall match score, for each client-side company, use the match scores to rank candidates and keep a predetermined number of top predetermined matches, and display the predetermined number of top predetermined matches using a user interface.
    Type: Application
    Filed: April 14, 2020
    Publication date: October 15, 2020
    Inventors: Hua Gao, Amit Rai
  • Publication number: 20200308145
    Abstract: The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
    Type: Application
    Filed: October 18, 2018
    Publication date: October 1, 2020
    Applicant: Amgen Inc.
    Inventors: Michael D. BARTBERGER, Nagasree CHAKKA, Hua GAO, Angel GUZMAN-PEREZ, Daniel B. HORNE, Zihao HUA, Madeleine KIEFFER, Daniel C. H. Lin, Benjamin Charles MILGRAM, Jane PANTELEEV, Laurie SCHENKEL, John STELLWAGEN, Matthew WEISS, Ryan D. WHITE, Wei ZHAO
  • Patent number: 10698785
    Abstract: A computer-implemented method, a computer program product, and a computer system for parallel task management. A computer system receives a new task that requests to access a resource may be received. In response to an access workload being above a first threshold, the computer system dispatches the new task to at least one predefined processing unit, wherein the access workload may be associated with the resource that is in parallel accessed by a plurality of existing tasks.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 30, 2020
    Assignee: International Business Machines Corporation
    Inventors: Ping Ping Cheng, Jun Hua Gao, Guan Jun Liu, Xue Yong Zhang, Xi Bo Zhu, Bei Chun Zhou
  • Publication number: 20200190210
    Abstract: Use of the extracellular loop 1 (ECL 1) of TM4SF1 as a target for cancer treatment. More specifically, specific binding of antibodies of the ECL1 of TM4SF1 and peptides of ECL1.
    Type: Application
    Filed: September 12, 2018
    Publication date: June 18, 2020
    Inventors: Jianmin FANG, Hua GAO, Guang CHEN, Yanxin YIN, Jia GUO
  • Patent number: 10666495
    Abstract: According to an embodiment of the present disclosure, there is provided a method for a distributed transaction processing environment. The method includes in response to determining that a state of a first node acting as a first coordinating node is not performing properly, selecting a second node from a first plurality of participating nodes communicatively coupled to the first node. The method further includes activating the selected second node to be a second coordinating node while deactivating the first node to be a participating node. In addition, the method includes performing a transaction based on a cooperation between the first and second nodes.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: May 26, 2020
    Assignee: International Business Machines Corporation
    Inventors: Ping Ping Cheng, Jun Hua Gao, Guan Jun Liu, Xue Yong Zhang, Bei Chun Zhou, Xi Bo Zhu
  • Patent number: 10666496
    Abstract: According to an embodiment of the present disclosure, there is provided a method for a distributed transaction processing environment. The method includes in response to determining that a state of a first node acting as a first coordinating node is not performing properly, selecting a second node from a first plurality of participating nodes communicatively coupled to the first node. The method further includes activating the selected second node to be a second coordinating node while deactivating the first node to be a participating node. In addition, the method includes performing a transaction based on a cooperation between the first and second nodes.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: May 26, 2020
    Assignee: International Business Machines Corporation
    Inventors: Ping Ping Cheng, Jun Hua Gao, Guan Jun Liu, Xue Yong Zhang, Bei Chun Zhou, Xi Bo Zhu
  • Publication number: 20200143241
    Abstract: An automated predictive analytics system disclosed herein provides a novel technique for industry classification. Leveraging specific API to construct a database of companies labeled with the industries to which they belong, the automated predictive analytics system trains a deep neural network to predict the industries of novel companies. The automated predictive analytics system examines the capacity of the model to predict six-digit NAICS codes, as well as the ability of the model architecture to adapt to other industry segmentation schemas. Additionally, the automated predictive analytics system investigates the ability of the model to generalize despite the presence of noise in the labels in the training set. Finally, the automated predictive analytics system explores the possibility of increasing predictive precision by thresholding based on the confidence scores that the model outputs along with its predictions.
    Type: Application
    Filed: October 29, 2019
    Publication date: May 7, 2020
    Inventors: Hua Gao, Amit Rai, Yi Jin, Rakesh Gowda, Joseph James Kardwell
  • Publication number: 20200104589
    Abstract: Some implementations of the disclosure involve, at a device having one or more processors, one or more image sensors, and an illumination source, detecting a first attribute of an eye based on pixel differences associated with different wavelengths of light in a first image of the eye. These implementations next determine a first location associated with the first attribute in a three dimensional (3D) coordinate system based on depth information from a depth sensor. Various implementations detect a second attribute of the eye based on a glint resulting from light of the illumination source reflecting off a cornea of the eye. These implementations next determine a second location associated with the second attribute in the 3D coordinate system based on the depth information from the depth sensor, and determine a gaze direction in the 3D coordinate system based on the first location and the second location.
    Type: Application
    Filed: September 13, 2019
    Publication date: April 2, 2020
    Inventors: Tom Sengelaub, Hua Gao, Hao Qin, Julia Benndorf
  • Publication number: 20190378149
    Abstract: An automated predictive analytics system disclosed herein provides for generating sales leads with lead engagement recommendations. In one implementation, the system determines similarities between fitness, engagement, and intent characteristics of a plurality of target clients and fitness, engagement, and intent characteristics of an entity's existing clients. Subsequently, the system generates recommendations for engagement with the plurality of target clients, wherein components of the recommendations for engagement are based on determined similarities between the fitness, engagement, and intent characteristics of the plurality of target clients and the fitness, engagement, and intent characteristics of the entity's existing clients. The system presents the plurality of leads with the recommendations of engagement to using a graphical user interface (GUI) at the application layer of the system.
    Type: Application
    Filed: July 31, 2019
    Publication date: December 12, 2019
    Inventors: Hua Gao, Vincent Yang, Yi Jin, Amit Rai
  • Publication number: 20190367945
    Abstract: In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained therein a paracrine-encoding nucleic acid or gene, and the expression vehicle, vector, recombinant virus, or equivalent can express the paracrine-encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence, or the expression vehicle, vector, recombinant virus, or equivalent, to an individual or a patient in need thereof, thereby treating, ameliorating or protecting (preventing) the individual or patient a
    Type: Application
    Filed: December 27, 2018
    Publication date: December 5, 2019
    Inventors: H. Kirk HAMMOND, Mei Hua GAO
  • Publication number: 20190264189
    Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating a heart failure in a subject in need thereof comprising administering to the subject an isolated or recombinant nucleic acid, an isolated or recombinant or chimeric polypeptide, or an engineered cell, as provided herein, thereby treating the subject. In alternative embodiments, the administration reduces left ventricular (LV) hypertrophy, increases LV peak pressure development, reduced cAMP production and/or improves LV peak pressure decay in a pressure-overload in the subject. In alternative embodiments, provided are compositions and methods for: treating, ameliorating, or slowing the progress of, or protecting (preventing) an individual or a patient against heart failure; or, reducing LV hypertrophy, increasing LV peak pressure development, and/or improving LV peak pressure decay in a pressure-overload in an individual in need thereof.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 29, 2019
    Inventors: H. Kirk HAMMOND, Mei Hua GAO, Ngai Chin LAI
  • Patent number: 10380609
    Abstract: An automated predictive analytics system disclosed herein provides for generating sales leads with lead engagement recommendations. In one implementation, the system determines similarities between fitness, engagement, and intent characteristics of a plurality of target clients and fitness, engagement, and intent characteristics of an entity's existing clients. Subsequently, the system generates recommendations for engagement with the plurality of target clients, wherein components of the recommendations for engagement are based on determined similarities between the fitness, engagement, and intent characteristics of the plurality of target clients and the fitness, engagement, and intent characteristics of the entity's existing clients. The system presents the plurality of leads with the recommendations of engagement to using a graphical user interface (GUI) at the application layer of the system.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: August 13, 2019
    Assignee: EVERSTRING INNOVATION TECHNOLOGY
    Inventors: Hua Gao, Vincent Yang, Yi Jin, Amit Rai
  • Patent number: 10353874
    Abstract: The present invention belongs to the information processing field and discloses a method and apparatus for associating information. The method for associating information comprises: obtaining identification information of a first content; associating the identification information of the first content with a second content, wherein the second content is created for the first content; obtaining identification information of a third content, wherein the third content is an updated version of the first content, the third content containing revision made according to the second content; and associating the identification information of the third content with the second content. With the method and system for associating information as provided by the present invention, contents of a plurality of versions can be managed and traced efficiently without a need to modify the existing code review flow.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 16, 2019
    Assignee: International Business Machines Corporation
    Inventors: Si Bin Fan, Jun Hua Gao, Guo Qiang Li, Wen Li, Cheng Fang Wang, Xiao Lin Zhang
  • Publication number: 20190205239
    Abstract: A method and associated computer system. A first machine executes machine code in a debugging session on the first machine. The machine code had been previously received by the first machine from a second machine. The machine code includes machine executable instructions. The machine code was generated from compilation of source code developed and compiled on the second machine. In response to a change in the machine code having detected by the first machine in the debugging session on the first machine, the first machine determines a portion of the source code associated with the change in the machine code based on a profile. The profile indicates a mapping between the source code and the machine code. The first machine, while communicating with the second machine, causes the portion of the source code to be updated on the second machine based on the change in the machine code.
    Type: Application
    Filed: March 8, 2019
    Publication date: July 4, 2019
    Inventors: Jun Hua Gao, Cheng Fang Wang, Xue Yong Zhang, Xi Bo Zhu
  • Patent number: 10318403
    Abstract: A method, and associated computer system and computer program product. A change of runtime code is detected by one or more processors of the computer system. The change is detected in a debugging session on a first machine. The runtime code is obtained from source code that is developed on a second machine that is different from the first machine. In response to the change being detected, a portion of the source code associated with the detected change is determined, by the one or more processors, based on a profile. The profile indicates a mapping between the source code and the runtime code. The portion of the source code is caused, by the one or more processors, to be updated based on the detected change in the runtime code.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 11, 2019
    Assignee: International Business Machines Corporation
    Inventors: Jun Hua Gao, Cheng Fang Wang, Xue Yong Zhang, Xi Bo Zhu