Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: Methods and apparatus for providing eye model matching in a device are disclosed. When a user activates a device and the presence of the user's eye is detected, an image of the user's eye is captured. An eye model matching process is then implemented to determine a stored eye model (e.g., an eye model stored after enrollment of the eye on the device) that best matches the eye in the captured image. Determination of the best matching eye model may be based on matching between properties of the user's eye in the captured image (such as cornea and pupil features) and properties of the user's eye determined by the eye model. The best matching eye model may then be implemented in, for example, an eye gaze tracking process. In certain instances, the best matching eye model satisfies a threshold for matching before being implemented in the downstream process.

Abstract: Methods and apparatus for correcting the gaze direction and the origin (entrance pupil) in gaze tracking systems. During enrollment after an eye model is obtained, the pose of the eye when looking at a target prompt is determined. This information is used to estimate the true visual axis of the eye. The visual axis may then be used to correct the point of view (PoV) with respect to the display during use. If a clip-on lens is present, a corrected gaze axis may be calculated based on the known optical characteristics and pose of the clip-on lens. A clip-on corrected entrance pupil may then be estimated by firing two or more virtual rays through the clip-on lens to determine the intersection between the rays and the corrected gaze axis.

Abstract: Systems and methods are disclosed to enable performance of a lens distance test in head-mounted displays (HMDs) to determine the distance between a user's eye and a lens of the HMD (e.g. the display lens in a virtual or augmented reality device). In embodiments, the HMD is configured to determine a current pose of the eye based on a series of captured eye images. The pose information is used to determine the distance from the apex of the cornea to a closest point on the lens. If the determined distance is too small or too large, an alert or notification is generated instructing to adjust the HMD or change the light seal to achieve better distancing, in order to reduce the risk of eye injury and/or improve user experience. In embodiments, the lens distance test may be repeated during a user session to reevaluate and/or monitor the lens distance.

Abstract: A personalized eye model is used to generate synthetic gaze features at ground-truth eye poses Gg. Corresponding synthetic gaze poses Gs are estimated from the synthetic gaze features using an average eye model. A linear regression is applied between Gg and Gs to generate a gaze correction function. The gaze correction function represents differences between the synthetic gaze Gs of the subject eye at the display and that of the average eye model Gg at the display, but does not contain security- or privacy-sensitive information. Further, the personalized eye model cannot be recovered from the gaze correction function, and thus the gaze correction function can be stored unencrypted and available for use during a cold boot of a device prior to login. On a cold boot of the device, the gaze correction function may be accessed and used with an average eye model to improve gaze-based interactions.

Abstract: A system for detecting a proximate object includes one or more cameras and one or more illuminators. The proximate object is detected by obtaining image data captured by the one or more cameras, where the image data is captured when at least one of the one or more illuminators are illuminated, determining brightness statistics from the image data, and determining whether the brightness statistics satisfies a predetermined threshold. The proximate object is determined to be detected in accordance with a determination that the brightness statistics satisfies the predetermined threshold.

Abstract: A method for control of a pixel array based on a temperature estimate is provided. A method includes sampling an anode voltage of each LED of a plurality of pixels resulting in sampled voltages, determining an average voltage based on the sample voltages, and determining a total voltage to provide to the pixels based on the average voltage and voltage data from a memory coupled to the controller, the voltage data including one or more of a 3-sigma value, a driver headroom value, a resistance value, or a k-factor value.

Abstract: For the problem of difficult roof anchor withdrawal at the end of a working face, a static crushing directional anchor withdrawal method at the end of a large-mining-height working face is provided. The method includes the following steps: designing key parameters of boreholes for static crushing, including a borehole position, a spacing between boreholes, a borehole depth, and a borehole diameter at the end of a working face; then determining parameters of a static crushing agent grouting technology device for the construction of a static crushing process; and carrying out an anchor withdrawal operation at the end.

Abstract: Provided are a coupling device, a surface wave coupling method, and an open wire surface wave wireless coverage system. The coupling device comprises: a high-order mode direct coupling module configured to couple a first electromagnetic wave from a transmitter to form a second electromagnetic wave propagating in a preset high-order guided wave mode; a mode converting and filtering module configured to convert the second electromagnetic wave into a third electromagnetic wave propagating in a superposition of a plurality of guided wave modes, and to filter the high-order guided wave mode in the third electromagnetic wave to obtain a fourth electromagnetic wave propagating in the preset low-order guided wave mode; and a mode matching module configured to convert the fourth electromagnetic wave into a fifth electromagnetic wave propagating along a surface of an open wire in a target guided wave mode.

Abstract: Disclosed are a method, apparatus, system and terminal device for measuring the total radiated power of an array antenna, and a non-transitory computer-readable storage medium. The method includes: dividing an array antenna to be measured into N antenna sub-arrays, the N being greater than or equal to 2; determining a sampling interval according to the sizes of the N antenna sub-arrays; determining sampling points according to the sampling interval; and determining the total radiated power of the entire array antenna according to the equivalent isotropic radiated power of the sampling points.

Abstract: Provided are a method, apparatus and system for measuring total radiated power of an array antenna. The method includes: determining a Rayleigh resolution of the array antenna in an angle space, and setting a stepping grid spacing of sampling points according to the Rayleigh resolution; determining the sampling points according to the stepping grid spacing, measuring equivalent isotropic radiated power (EIRP) at positions of the sampling points and determining the TRP according to the EIRP. Compared with a traditional rest mode using an angle stepping grid ?grid and ?grid of 15°, this reduces measurement errors; and additionally, through a normalized wave vector space transformation, the number of sampling points is further reduced, and the measurement efficiency is improved.

Abstract: Methods and apparatus for using polarized light (e.g., infrared (IR) light) to improve eye-related functions such as iris recognition. An eye camera system includes one or more IR cameras that capture images of the user's eyes that are processed to perform iris recognition, gaze tracking, or other functions. At least one polarizing element may be located in the path of the light which is used to capture images of the user's eye. The user's eye may be illuminated by IR light emitted by one or more LEDs. At least one of the LEDs may be an LED with a polarizing filter. Instead or in addition, at least one polarizer may be located at the eye camera sensor, in the eye camera optics, or as or in an additional optical element located on the light path between the eye camera and the user's eye.

Abstract: A light emission control device includes at least one processor. The processor performs dimming control on a light emitting device by interrupt processing.

Abstract: Various implementations disclosed herein include an inconspicuous eye enrollment for user devices through the simultaneous or near-simultaneous eye characteristic tracking and eye model updating. The implementations disclosed herein direct light towards an eye of a user to produce glint reflections and obtain, via one or more sensors, image frames comprising depictions of the glint reflections. Based on those image frames, the implementations disclosed herein track eye characteristics and update an eye model of the eye during a period of time between obtaining a first image frame of the image frames and obtaining a second image frame of the image frames.

Abstract: Provided are a method, apparatus and system for measuring total radiated power of an array antenna. The method includes: determining a Rayleigh resolution of the array antenna in an angle space, and setting a stepping grid spacing of sampling points according to the Rayleigh resolution; determining the sampling points according to the stepping grid spacing, measuring equivalent isotropic radiated power (EIRP) at positions of the sampling points, and determining the TRP according to the EIRP. Compared with a traditional test mode using an angle stepping grid ?grid and ?grid of 15°, this reduces measurement errors; and additionally, through a normalized wave vector space transformation, the number of sampling points is further reduced, and the measurement efficiency is improved.

Abstract: Methods and apparatus for stray light mitigation in optical systems that include two or more illumination sources (e.g., point light sources such as light-emitting diodes (LEDs)) that illuminate an object to be imaged, and a camera configured to capture images of light from the point light sources reflected by the object when illuminated. To mitigate “occlusions” or artifacts caused by, for example, stray light or reflections of the illumination sources off of other components of the system, multiple images of the object are captured with different groups of the illumination sources enabled. The captured images can then be processed and merged to generate an output image with the occlusions or artifacts caused by stray light or reflections mitigated or eliminated.

Abstract: The present invention is directed to 3-(1H-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating a heart failure in a subject in need thereof comprising administering to the subject an isolated or recombinant nucleic acid, an isolated or recombinant or chimeric polypeptide, or an engineered cell, as provided herein, thereby treating the subject. In alternative embodiments, the administration reduces left ventricular (LV) hypertrophy, increases LV peak pressure development, reduced cAMP production and/or improves LV peak pressure decay in a pressure-overload in the subject. In alternative embodiments, provided are compositions and methods for: treating, ameliorating, or slowing the progress of, or protecting (preventing) an individual or a patient against heart failure; or, reducing LV hypertrophy, increasing LV peak pressure development, and/or improving LV peak pressure decay in a pressure-overload in an individual in need thereof.

Abstract: Some implementations of the disclosure involve, at a device having one or more processors, one or more image sensors, and an illumination source, detecting a first attribute of an eye based on pixel differences associated with different wavelengths of light in a first image of the eye. These implementations next determine a first location associated with the first attribute in a three dimensional (3D) coordinate system based on depth information from a depth sensor. Various implementations detect a second attribute of the eye based on a glint resulting from light of the illumination source reflecting off a cornea of the eye. These implementations next determine a second location associated with the second attribute in the 3D coordinate system based on the depth information from the depth sensor, and determine a gaze direction in the 3D coordinate system based on the first location and the second location.

Abstract: A tundish, wherein a steel passing hole (43) is provided at a lower portion of a gas-curtain weir refractory body (42); an argon duct (46), a gas chamber (45) and a gas-permeable brick (44) are connected to form a gas-curtain generating device, and the gas-curtain generating device is installed at the lower portion of the gas-curtain weir refractory body (42); the gas-permeable brick (44) is provided in association with the position of the steel passing hole (43), and a length of the gas-permeable brick is designed larger than a width of the steel passing hole (43); and a gas-curtain weir plate (4) is provided in a tundish container, the gas-curtain weir refractory body (42) crosses the tundish container horizontally, and divides the tundish container into a first region and a second region.