Patents by Inventor Hua Kuang
Hua Kuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Hybridoma cell line of secreting clarithromycin monoclonal antibodies and preparation method thereof
Publication number: 20190284304Abstract: A hybridoma cell line of secreting clarithromycin monoclonal antibodies with a preservation number of hybridoma cell line of CGMCC No. 14696 belongs to the field of food safety immunological detection. BALB/c mice are immunized through one time immunization with complete freund's adjuvant, three times of booster immunization with incomplete freund's adjuvant and one time of rush immunization with clarithromycin complete antigen without adjuvant; the spleen cells from BALB/C mice immunized with high potency and low value of IC50 are fused with murine myeloma cells; and then the hybridoma cell line is obtained through indirect competitive ELISA screening and three subclones. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to clarithromycin (value of IC50 is 0.3 ng/ml), being suitable for detection of clarithromycin in food.Type: ApplicationFiled: April 25, 2019Publication date: September 19, 2019Inventors: Chuanlai XU, Hua KUANG, Lu ZENG, Liguang XU, Liqiang LIU, Shanshan SONG, Xiaoling WU, Yongming HU -
Publication number: 20190217344Abstract: A cup wash disk for cleaning a photoresist process tool is provided. An upper plate is arranged over a lower plate to define a cavity between the upper and lower plates. The lower plate comprises peripheral openings in fluid communication with the cavity and arranged along a periphery of the lower plate. A plurality of shims is arranged between the upper and lower plates to space the upper and lower plates and to define slits between the upper and lower plates. The slits are in fluid communication with the cavity. A method for cleaning the photoresist process tool using the cup wash disk is also provided.Type: ApplicationFiled: March 21, 2019Publication date: July 18, 2019Inventors: Hua-Kuang Teng, Yu-Xiang Lin, Tien-Zeng Fang
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Hybridoma cell line of secreting clarithromycin monoclonal antibodies and preparation method thereof
Patent number: 10323100Abstract: A hybridoma cell line of secreting clarithromycin monoclonal antibodies with a preservation number of hybridoma cell line of CGMCC No. 14696 belongs to the field of food safety immunological detection. BALB/c mice are immunized through one time immunization with complete freund's adjuvant, three times of booster immunization with incomplete freund's adjuvant and one time of rush immunization with clarithromycin complete antigen without adjuvant; the spleen cells from BALB/C mice immunized with high potency and low value of IC50 are fused with murine myeloma cells; and then the hybridoma cell line is obtained through indirect competitive ELISA screening and three subclones. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to clarithromycin (value of IC50 is 0.3 ng/ml), being suitable for detection of clarithromycin in food.Type: GrantFiled: December 17, 2018Date of Patent: June 18, 2019Assignee: JIANGNAN UNIVERSITYInventors: Chuanlai Xu, Hua Kuang, Lu Zeng, Liguang Xu, Liqiang Liu, Shanshan Song, Xiaoling Wu, Yongming Hu -
Patent number: 10265735Abstract: A cup wash disk for cleaning a photoresist process tool is provided. An upper plate is arranged over a lower plate to define a cavity between the upper and lower plates. The lower plate comprises peripheral openings in fluid communication with the cavity and arranged along a periphery of the lower plate. A plurality of shims is arranged between the upper and lower plates to space the upper and lower plates and to define slits between the upper and lower plates. The slits are in fluid communication with the cavity. A method for cleaning the photoresist process tool using the cup wash disk is also provided.Type: GrantFiled: January 14, 2016Date of Patent: April 23, 2019Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Hua-Kuang Teng, Yu-Xiang Lin, Tien-Zeng Fang
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Patent number: 9720325Abstract: A method includes rotating a wafer at a first speed for a first time duration. The wafer is rotated at a second speed that is lower than the first speed for a second time duration after the first time duration. The wafer is rotated at a third speed that is higher than the second speed for a third time duration after the second time duration. A photoresist is dispensed on the wafer during the first time duration and at least a portion of a time interval that includes the second time duration and the third time duration.Type: GrantFiled: September 17, 2013Date of Patent: August 1, 2017Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Chih-Hsien Hsu, Hong-Hsing Chou, Hu-Wei Lin, Chi-Jen Hsieh, Jr-Wei Ye, Yuan-Ting Huang, Ching-Hsing Chiang, Hua-Kuang Teng, Yen-Chen Lin, Carolina Poe, Tsung-Cheng Huang, Chia-Hung Chu
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Publication number: 20170203341Abstract: A cup wash disk for cleaning a photoresist process tool is provided. An upper plate is arranged over a lower plate to define a cavity between the upper and lower plates. The lower plate comprises peripheral openings in fluid communication with the cavity and arranged along a periphery of the lower plate. A plurality of shims is arranged between the upper and lower plates to space the upper and lower plates and to define slits between the upper and lower plates. The slits are in fluid communication with the cavity. A method for cleaning the photoresist process tool using the cup wash disk is also provided.Type: ApplicationFiled: January 14, 2016Publication date: July 20, 2017Inventors: Hua-Kuang Teng, Yu-Xiang Lin, Tien-Zeng Fang
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Patent number: 9575012Abstract: In semiconductor fabrication processes, one or more wafers are often exposed to processes such as chemical vapor deposition to form semiconductor components thereupon. Often, some of the wafers exhibit flaws due to contamination or processing errors occurring before, during, or after component formation. Inspection of the wafers is often performed by direct visual inspection of humans, which is prone to errors due to flaws that are too small to view directly; to particles naturally arising in the human eye; and to fatigue caused by inspection of large numbers of wafers. Presented herein are inspection techniques involving positioning the wafer in a dark chamber exposing the surface of the wafer to a light source at a first angle, and capturing with a camera an image of the light source reflected from the surface of the wafer at a second angle. Wafers identified as exhibiting flaws are removed from the wafer set.Type: GrantFiled: September 27, 2013Date of Patent: February 21, 2017Assignee: Taiwan Semiconductor Manufacturing Company LimitedInventors: Hu-Wei Lin, Hsiao-Yu Chen, Jr-Wei Ye, Hong-Hsing Chou, Chih-Hsien Hsu, Tsung-Cheng Huang, Hua-Kuang Teng, Hsieh Chi-Jen, Chun-Chih Chen
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Publication number: 20150079806Abstract: A method includes rotating a wafer at a first speed for a first time duration. The wafer is rotated at a second speed that is lower than the first speed for a second time duration after the first time duration. The wafer is rotated at a third speed that is higher than the second speed for a third time duration after the second time duration. A photoresist is dispensed on the wafer during the first time duration and at least a portion of a time interval that includes the second time duration and the third time duration.Type: ApplicationFiled: September 17, 2013Publication date: March 19, 2015Inventors: Chih-Hsien Hsu, Hong-Hsing Chou, Hu-Wei Lin, Chi-Jen Hsieh, Jr-Wei Ye, Yuan-Ting Huang, Ching-Hsing Chiang, Hua-Kuang Teng, Yen-Chen Lin, Carolina Poe, Tsung-Cheng Huang, Chia-Hung Chu
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Patent number: 8926808Abstract: An electrochemical paper-immunosensor and method for detecting aminoglycoside antibiotics is developed in the present invention. Single-walled carbon nanotubes are coated on the common filtration paper by dip-dry cycles. With antibody against neomycin adding to the coating solution, a high sensitive biosensor for specific detection of neomycin is prepared, satisfying to the rigid authority regulations. The sensor is not only sensitive but also rapid, comparing with the classic ELISA method, with LOD of 0.04 ng mL?1 and the whole detection process lasting less than 30 min. Another notable advantage of this invention is the versatility of the sensor, similar method is engaged to prepare the versatile sensor for other aminoglycoside antibiotics, replacement with relevant antibodies.Type: GrantFiled: November 25, 2011Date of Patent: January 6, 2015Assignee: Jiangnan UniversityInventors: Chuanlai Xu, Libing Wang, Xiaoling Wu, Hua Kuang, Wei Chen, Wei Ma
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Publication number: 20140267692Abstract: In semiconductor fabrication processes, one or more wafers are often exposed to processes such as chemical vapor deposition to form semiconductor components thereupon. Often, some of the wafers exhibit flaws due to contamination or processing errors occurring before, during, or after component formation. Inspection of the wafers is often performed by direct visual inspection of humans, which is prone to errors due to flaws that are too small to view directly; to particles naturally arising in the human eye; and to fatigue caused by inspection of large numbers of wafers. Presented herein are inspection techniques involving positioning the wafer in a dark chamber exposing the surface of the wafer to a light source at a first angle, and capturing with a camera an image of the light source reflected from the surface of the wafer at a second angle. Wafers identified as exhibiting flaws are removed from the wafer set.Type: ApplicationFiled: September 27, 2013Publication date: September 18, 2014Applicant: Taiwan Semiconductor Manufacturing Company LimitedInventors: Lin Hu-Wei, Hsiao-Yu Chen, Jr-Wei Ye, Hong-Hsing Chou, Chih-Hsien Hsu, Tsung-Cheng Huang, Teng Hua-Kuang, Hsieh Chi-Jen, Chun-Chih Chen
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Publication number: 20120325681Abstract: An electrochemical paper-immunosensor and method for detecting aminoglycoside antibiotics is developed in the present invention. Single-walled carbon nanotubes are coated on the common filtration paper by dip-dry cycles. With antibody against neomycin adding to the coating solution, a high sensitive biosensor for specific detection of neomycin is prepared, satisfying to the rigid authority regulations. The sensor is not only sensitive but also rapid, comparing with the classic ELISA method, with LOD of 0.04 ng mL?1 and the whole detection process lasting less than 30 min. Another notable advantage of this invention is the versatility of the sensor, similar method is engaged to prepare the versatile sensor for other aminoglycoside antibiotics, replacement with relevant antibodies.Type: ApplicationFiled: November 25, 2011Publication date: December 27, 2012Inventors: Chuanlai Xu, Libing Wang, Xiaoling Wu, Hua Kuang, Wei Chen, Wei Ma
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Patent number: 5544280Abstract: A unipolar terminal-attractor based neural associative memory (TABAM) system with adaptive threshold for perfect convergence is presented. By adaptively setting the threshold values for the dynamic iteration for the unipolar binary neuron states with terminal-attractors for the purpose of reducing the spurious states in a Hopfield neural network for associative memory and using the inner-product approach, perfect convergence and correct retrieval is achieved. Simulation is completed with a small number of stored states (M) and a small number of neurons (N) but a large M/N ratio. An experiment with optical exclusive-OR logic operation using LCTV SLMs shows the feasibility of optoelectronic implementation of the models. A complete inner-product TABAM is implemented using a PC for calculation of adaptive threshold values to achieve a unipolar TABAM (UIT) in the case where there is no crosstalk, and a crosstalk model (CRIT) in the case where crosstalk corrupts the desired state.Type: GrantFiled: June 7, 1993Date of Patent: August 6, 1996Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Hua-Kuang Liu, Jacob Barhen, Nabil H. Farhat, Chwan-Hwa Wu
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Patent number: 5539543Abstract: A system for optically providing one-to-many irregular interconnections, and strength-adjustable many-to-many irregular interconnections which may be provided with strengths (weights) w.sub.ij using multiple laser beams which address multiple holograms and means for combining the beams modified by the holograms to form multiple interconnections, such as a cross-bar switching network. The optical means for interconnection is based on entering a series of complex computer-generated holograms on an electrically addressed spatial light modulator for real-time reconfigurations, thus providing flexibility for interconnection networks for large-scale practical use. By employing multiple sources and holograms, the number of interconnection patterns achieved is increased greatly.Type: GrantFiled: January 27, 1994Date of Patent: July 23, 1996Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Hua-Kuang Liu, Shaomin Zhou
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Patent number: 5412755Abstract: An optical implementation of an inner-product neural associative memory is realized with a first spatial light modulator for entering an initial two-dimensional N-tuple vector and for entering a thresholded output vector image after each iteration until convergence is reached, and a second spatial light modulator for entering M weighted vectors of inner-product scalars multiplied with each of the M stored vectors, where the inner-product scalars are produced by multiplication of the initial input vector in the first iterative cycle (and thresholded vectors in subsequent iterative cycles) with each of the M stored vectors, and the weighted vectors are produced by multiplication of the scalars with corresponding ones of the stored vectors. A Hughes liquid crystal light valve is used for the dual function of summing the weighted vectors and thresholding the sum vector.Type: GrantFiled: February 8, 1994Date of Patent: May 2, 1995Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventor: Hua-Kuang Liu
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Patent number: 5282067Abstract: A self amplifying optical pattern recognizer includes a geometric system configuration similar to that of a Vander Lugt holographic matched filter configuration with a photorefractive crystal specifically oriented with respect to the input beams. An extraordinarily polarized, spherically converging object image beam is formed by laser illumination of an input object image and applied through a photorefractive crystal, such as a barium titanite (BaTiO.sub.3) crystal. A volume or thin-film difORIGIN OF THE INVENTIONThe invention described herein was made in the performance of work under a NASA contract, and is subject to the provisions of Public Law 96-517 (35 USC 202) in which the Contractor has elected to retain title.Type: GrantFiled: October 7, 1991Date of Patent: January 25, 1994Assignee: California Institute of TechnologyInventor: Hua-Kuang Liu
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Patent number: 5257389Abstract: An inner-product array processor is provided with thresholding of the inner product during each iteration to make more significant the inner product employed in estimating a vector to be used as the input vector for the next iteration. While stored vectors and estimated vectors are represented in bipolar binary (1,-1), only those elements of an initial partial input vector that are believed to be common with those of a stored vector are represented in bipolar binary; the remaining elements of a partial input vector are set to 0. This mode of representation, in which the known elements of a partial input vector are in bipolar binary form and the remaining elements are set equal to 0, is referred to as trinary representation. The initial inner products corresponding to the partial input vector will then be equal to the number of known elements. Inner-product thresholding is applied to accelerate convergence and to avoid convergence to a negative input product.Type: GrantFiled: April 27, 1990Date of Patent: October 26, 1993Assignee: California Institute of TechnologyInventors: Hua-Kuang Liu, Abdul A. S. Awwal, Mohammad A. Karim
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Patent number: 5161027Abstract: A relatively small and low-cost system is provided for projecting a large and bright television image onto a screen. A minature liquid crystal array is driven by video circuitry to produce a pattern of transparencies in the array corresponding to a television image. Light is directed against the rear surface of the array to illuminate it, while a projection lens lies in front of the array to project the image of the array onto a large screen. Grid lines in the liquid crystal array are eliminated by a spacial filter which comprises a negative of the Fourier transform of the grid.Type: GrantFiled: December 21, 1990Date of Patent: November 3, 1992Assignee: The United States of America as represented by the Administrator, National Aeronautics and Space AdministrationInventor: Hua-Kuang Liu
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Patent number: 5130530Abstract: A real-time, pre-detection optical dynamic range compression system uses a photorefractive crystal, such as BaTiO.sub.3 or LiNbO.sub.3, in which light induced scattering from crystal inhomogeneities of the optical input occurs as a nonlinear function of the input intensity. The greater the intensity, the faster random interference gratings are created to scatter the incident light. The unscattered portion of the optical signal is therefore reduced in dynamic range over time. The amount or range of dynamic range compression may be controlled by adjusting the time of application of the unscattered crystal output to the photodetector with regard to the time of application of the optical input to the crystal.Type: GrantFiled: December 19, 1990Date of Patent: July 14, 1992Assignee: The United States of America as represented by the Administrator, National Aeronautics and Space AdministrationInventor: Hua-Kuang Liu
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Patent number: 5019898Abstract: A method and apparatus are disclosed for real-time optical broadband pseudocolor encoding of an image. A light polarization spatial modulator is utilized to density encode an incident beam of plane-polarized light; the beam is dispersed into its primary colors; the polarizations of the dispersed beams are analyzed to produce positive, negative, and bidirectionally modualated images which are each separately encoded with a primary color; and the primary-color encoded beams are combined to produce a pseudocolored image. In a preferred embodiment the pseudocolor encoding apparatus comprises a compact white-light projection system and a liquid-crystal television spatial light polarization modulator. The invention makes possible the large-screen display of broadband pseudocolor images from real-world input scenes from a television camera.Type: GrantFiled: April 26, 1989Date of Patent: May 28, 1991Assignee: The California Institute of TechnologyInventors: Tien-Hsin Chao, Hua-Kuang Liu
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Patent number: 5005954Abstract: A method and apparatus for generation of second-rank tensors using a photorefractive crystal to perform the outer-product between two vectors via four-wave mixing, thereby taking 2n input data to a control n.sup.2 output data points. Two orthogonal amplitude modulated coherent vector beams x and y are expanded and then collimated before directing them onto two opposing parallel sides of the photorefractive crystal in exact opposition. A beamsplitter is used to direct a coherent pumping beam onto the crystal at an appropriate angle so as to produce a conjugate beam that is the matrix product of the vector beams x and y, and to separate the resulting conjugate beam that propagates in the exact opposite direction from the pumping beam. The conjugate beam thus separated is the tensor output xy.sup.T.Type: GrantFiled: February 16, 1989Date of Patent: April 9, 1991Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventor: Hua-Kuang Liu