Patents by Inventor Hualiang Huang

Hualiang Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene Engineering Recombinant Anti-CEA, Anti-CD3, And Anti-CD28 Single-Chain Tri-Specific Antibody
    Publication number: 20090117108
    Abstract: The invention is related to a recombinant single-chain tri-specific antibody made from anti-Tumor Associated Antigen (TAA) antibody, FC interlinker, anti-CD3 antibody, HSA interlinker and anti-CD28 antibody in turn. Particularly, the invention relates to an anti-CEA, anti-CD3, anti-CD28 recombinant single-chain tri-specific antibody, CEA-scTsAb, which was constructed with three tandem antibody fragments (anti-CEA scFv, anti-CD3 scFv and anti-CD28 single-domain antibody) linked by two interlinkers (FC interlinker, HSA interlinker), and could be appended by C myc tag or histidine tag ((His)6-tag) at the C terminal. It also concerns a method for construction, expression and purification of the antibody. It also offers the encoded DNA sequence of the antibody, expression vectors and host cells for the vectors.
    Type: Application
    Filed: March 29, 2005
    Publication date: May 7, 2009
    Inventors: Xiangbin Wang, Hualiang Huang, Baofeng Zhao, Qi Zhao, Jinhua Piao, Qing Lin
  • Anti human ovarian cancer-anti CD3 bispecific antibody
    Publication number: 20080138339
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Application
    Filed: August 22, 2007
    Publication date: June 12, 2008
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Jie Feng, Ping Zhou, Xiaocong Yu, Qing Lin
  • Anti human ovarian cancer-anti CD3 bispecific antibody
    Patent number: 7262276
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: August 28, 2007
    Assignee: Beijing ABT Genetic Engineering Technology Co. Ltd.
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Xiaocong Yu, Jie Feng, Ping Zhou, Qing Lin
  • Anti human ovarian cancer-anti cd3 bispecific antibody
    Publication number: 20050255115
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Application
    Filed: May 23, 2002
    Publication date: November 17, 2005
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Jie Feng, Ping Zhou, Xiaocong Yu, Qing Lin