Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: An apparatus for use in a high-definition media interface (HDMI) source device includes an HDMI interface for transmitting video data and metadata to a sink device. The apparatus is configured to encode the metadata in an auxiliary video information (AVI) information frame (InfoFrame). The apparatus is further configured to transmit the AVI InfoFrame during a frame synchronous transmission window (FSTW) of the video data, wherein the FSTW begins during a video blanking interval (VBI) of the video data, on a first video blank pixel that immediately follows a last active video pixel of a preceding video frame or video field and ends a predetermined number of video lines after a start of the VBI.

Abstract: A circuit structure for improving the harmonic suppression capability of a radio frequency power amplifier includes an output stage unit, a high-order harmonic suppression unit, and a low-order harmonic suppression unit. The output stage unit outputs a signal to be subjected to harmonic suppression; the high-order harmonic suppression unit comprises a first filter capacitor and a back hole, and is used for suppressing fifth or higher harmonics; the output stage unit and the first filter capacitor are connected to the ground in series by means of the back hole; the low-order harmonic suppression unit is connected to the output stage unit to suppress second, third and fourth harmonics. According to the design, the high-harmonic suppression capability of the radio frequency power amplifier is improved.

Abstract: Ozone generating machine for generating ozone in a ship, comprising: an ozone generator (OG), a liquid cooling circuit portion, a frame, comprising a base (B) for laying on the ground, a top subframe (TSF) supporting the ozone generator (OG), and at least one pair of pillars (P) arranged between the base (B) and the top subframe (TSF), characterized in that the frame comprises: at least one pair of cross-brace beams (CB), for linking the pillars (P), a plurality of dampers (D) attached to a bottom of the base (B).

Abstract: A method for determining a bonding pad spacing on the surface of a bonding wire chip includes the steps of setting a loop height (“K”); selecting a capillary, measuring an expansion angle of a capillary sharp mouth (“C”); measuring the diameter of the capillary sharp mouth (“T”); measuring the hole diameter of the capillary (“H”); and determining a bonding pad spacing on the surface of a bonding wire chip (“P”). The formula is as follows: P=(T+H)/2+[tan(C/2)]*K. This method more accurately determines bonding pad spacing on the surface of a bonding wire chip, thereby providing a wider performance adjustment space. Additionally, problems, such as mutual inductance abnormalities caused by wire deformation or even by short circuits with other circuits due to the contact between a packaged capillary and a bonded wire can be lowered, thereby improving the working efficiency and reducing the number of times verification is performed.

Abstract: An embodiment provides a packet transmission method and apparatus, to resolve a problem that occurs when a packet cannot traverse a NAT device when VTEPs communicate with each other through the NAT device. The method is applied to a VXLAN including a first VTEP, a second VTEP, and a NAT device. The method includes: performing, by the first VTEP, VXLAN encapsulation on a first packet, obtaining a second packet; sending, by the first VTEP, the second packet to the second VTEP through the NAT device; and performing, by the second VTEP, VXLAN decapsulation on the received second packet, to obtain the first packet. The first packet is a packet to be sent by the first VTEP, a destination port number of the second packet is obtained based on a destination IP address of the second packet, and a source port number of the second packet is a preset port number.

Abstract: An apparatus for use in a high-definition media interface (HDMI) source device includes an HDMI interface for transmitting video data and metadata to a sink device. The apparatus is configured to encode the metadata in an auxiliary video information (AVI) information frame (InfoFrame). The apparatus is further configured to transmit the AVI InfoFrame during a frame synchronous transmission window (FSTW) of the video data, wherein the FSTW begins during a video blanking interval (VBI) of the video data, on a first video blank pixel that immediately follows a last active video pixel of a preceding video frame or video field and ends a predetermined number of video lines after a start of the VBI.

Abstract: An apparatus for use in a high-definition media interface (HDMI) source device includes an HDMI interface for transmitting video data and metadata to a sink device. The apparatus is configured to encode the metadata in an auxiliary video information (AVI) information frame (InfoFrame). The apparatus is further configured to transmit the AVI InfoFrame during a frame synchronous transmission window (FSTW) of the video data, wherein the FSTW begins during a video blanking interval (VBI) of the video data, on a first video blank pixel that immediately follows a last active video pixel of a preceding video frame or video field and ends a predetermined number of video lines after a start of the VBI.

Abstract: The present disclosure describes combination therapies comprising an agonist of OX40 and an agonist of 4-1BB, and the use of the combination therapies for the treatment of cancer.

Abstract: A power amplifier gain attenuation circuit includes: a gain attenuation (reduction) circuit configured to receive an input signal, an external drive signal and a bias voltage, and output a secondary input signal after attenuating the input signal depending on the drive signal and bias voltage; an amplifier including: a bias input terminal configured to receive a bias voltage; a signal input terminal configured to receive a secondary input signal, and an output terminal configured to output a gained output signal. The power amplifier gain attenuation circuit can reduce a gain effectively, and the amount of phase jump caused by the attenuation is quite small.

Abstract: A multi-mode multi-band power amplifier includes a controller, a wide-band amplifier channel and a fundamental impedance transformer. The controller receives an external signal and outputs a control signal according to the external signal. The wide-band amplifier channel receives single-band or multi-band RF signals through the input terminal, performs power amplification on the RF signals and outputs the RF signals through the output terminal. The fundamental impedance transformer includes a first segment shared by RF signals in all bands, second segments respectively special for RF signals in all bands, and a switching circuit controlled by the controller to separate RF signals subject to power amplification to the second segment in a switchable manner for multiplexed outputs.

Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death Ligand 1 receptor (PD-L1) and another therapeutic agent, and the use of the combination therapies for the treatment of cancer.

Abstract: A power amplifier gain attenuation circuit includes: a gain attenuation (reduction) circuit configured to receive an input signal, an external drive signal and a bias voltage, and output a secondary input signal after attenuating the input signal depending on the drive signal and bias voltage; an amplifier including: a bias input terminal configured to receive a bias voltage; a signal input terminal configured to receive a secondary input signal, and an output terminal configured to output a gained output signal. The power amplifier gain attenuation circuit can reduce a gain effectively, and the amount of phase jump caused by the attenuation is quite small.

Abstract: A power amplifier output power control circuit includes a first operational amplifier with a negative input terminal configured to receive a power control signal; a first PMOS transistor with a grid electrode connected to an output terminal of the first operational amplifier, a source electrode connected to an external power source, and a drain electrode grounded via a voltage dividing network; a power amplifier with a power end connected to the drain electrode of the first PMOS transistor, an input terminal configured to access to a signal to be amplified, and an output terminal configured to amplify the signal; and a current sampling circuit configured to produce sampling current after sampling current across the first PMOS transistor and providing a negative feedback signal for the positive input terminal of the first operational amplifier according to the sampling current such that total output power of the power amplifier keeps unchanged.

Abstract: A power amplifier output power control circuit includes a first operational amplifier with a negative input terminal configured to receive a power control signal; a first PMOS transistor with a grid electrode connected to an output terminal of the first operational amplifier, a source electrode connected to an external power source, and a drain electrode grounded via a voltage dividing network; a power amplifier with a power end connected to the drain electrode of the first PMOS transistor, an input terminal configured to access to a signal to be amplified, and an output terminal configured to amplify the signal; and a current sampling circuit configured to produce sampling current after sampling current across the first PMOS transistor and providing a negative feedback signal for the positive input terminal of the first operational amplifier according to the sampling current such that total output power of the power amplifier keeps unchanged.

Abstract: A multi-mode multi-band power amplifier includes a controller, a wide-band amplifier channel and a fundamental impedance transformer. The controller receives an external signal and outputs a control signal according to the external signal. The wide-band amplifier channel receives single-band or multi-band RF signals through the input terminal, performs power amplification on the RF signals and outputs the RF signals through the output terminal. The fundamental impedance transformer includes a first segment shared by RF signals in all bands, second segments respectively special for RF signals in all bands, and a switching circuit controlled by the controller to separate RF signals subject to power amplification to the second segment in a switchable manner for multiplexed outputs.

Abstract: A power amplifier gain switching circuit includes: a gain controller configured to receive an external input signal, output a first input signal, receive an external drive signal, and output a control signal based on the drive signal; an amplifier including: a bias input terminal configured to receive an external bias voltage; a signal input terminal configured to receive the first input signal; a control terminal configured to receive the control signal; and an output terminal configured to output an output signal with a gain; wherein the amplifier is configured to switch a gain factor of the output signal based on the control signal.

Abstract: A power amplifier gain switching circuit includes: a gain controller configured to receive an external input signal, output a first input signal, receive an external drive signal, and output a control signal based on the drive signal; an amplifier including: a bias input terminal configured to receive an external bias voltage; a signal input terminal configured to receive the first input signal; a control terminal configured to receive the control signal; and an output terminal configured to output an output signal with a gain; wherein the amplifier is configured to switch a gain factor of the output signal based on the control signal.

Abstract: A multi-mode multi-band power amplifier and its circuits are provided. The power amplifier comprises a controller, a wide-band amplifier channel, and a fundamental impedance transformer. The controller receives an external signal and outputs a control signal according to the external signal. The wide-band amplifier channel receives a single-band or a multi-band RF signals through the input terminal, performs power amplification on the RF signals and outputs the RF signals through the output terminal. The fundamental impedance transformer comprises a first segment shared by RF signals in all bands, second segments respectively specific to RF signals in all bands, and a switching circuit controlled by the controller to separate a RF signal which is subject to power amplification to the second segment in a switchable manner for multiplexed outputs. A power amplifier output power control circuit, a gain switching circuit, and a gain attenuation circuit are also provided.

Abstract: The present disclosure provides an image generation method and apparatus, and a terminal device. The image generation method includes the steps of: obtaining an environmental color temperature; adjusting proportions of light intensities of a first flash lamp (LED A), a second flash lamp (LED B) and a third flash lamp (LED C) to obtain a first mixed light after the adjustment, so that a chromaticity coordinate of the first mixed light (Mix 1) is located on a planckian locus, and a color temperature of the first mixed light is equal to the environmental color temperature; taking the first mixed light as flash lamp light to generate an image. Through the embodiments of the present disclosure, the color temperature of the flash lamp is matched with the environmental color temperature, and it is beneficial for the mobile terminal to perform an automatic white balance processing, thereby improving the quality of the generated image, and providing the user with better experiences.