Patents by Inventor Hua-Xin Liao

Hua-Xin Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV-1 neutralizing antibodies and uses thereof
    Patent number: 11944681
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: April 2, 2024
    Assignees: Duke University, University of Maryland
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, LaTonya Williams, Kevin J. Wiehe, Gilad Adi Ofek
  • Methods of inhibiting complement factor H (CFH) comprising administering an antibody that binds CFH
    Patent number: 11897946
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: February 13, 2024
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 11884704
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 30, 2024
    Assignees: DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin O. Saunders
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF
    Publication number: 20220096632
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Application
    Filed: June 24, 2021
    Publication date: March 31, 2022
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, M. Anthony MOODY, LaTonya WILLIAMS, Kevin J. WIEHE, Gilad Adi OFEK
  • INHIBITORS OF COMPLEMENT FACTOR H
    Publication number: 20210395353
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Application
    Filed: August 26, 2021
    Publication date: December 23, 2021
    Inventors: Edward F. Patz, JR., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • Anti-complement factor H antibodies
    Patent number: 11136380
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: October 5, 2021
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20210277065
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 9, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin O. SAUNDERS
  • Methods for reducing HIV-1 mother-to-child transmission by inducing V3-specific or CD4 binding site-specific antibodies
    Patent number: 11077130
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 3, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • HIV-1 neutralizing antibodies and uses thereof
    Patent number: 11071783
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 27, 2021
    Assignees: DUKE UNIVERSITY, UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, LaTonya Williams, Kevin J. Wiehe, Gilad Adi Ofek
  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 10968255
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 6, 2021
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • Consensus/ancestral immunogens
    Patent number: 10946090
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 16, 2021
    Assignees: Duke University, The University of Alabama at Birmingham Research Foundation, Triad National Security, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise L. Monti, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • COMPLEMENT FACTOR H ANTIBODIES
    Publication number: 20210061891
    Abstract: Disclosed herein are Complement factor H (CFH) antibodies and methods of using the antibodies.
    Type: Application
    Filed: October 21, 2020
    Publication date: March 4, 2021
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody
  • Complement factor H antibodies
    Patent number: 10865238
    Abstract: Disclosed herein are Complement factor H (CFH) antibodies and methods of using the antibodies.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 15, 2020
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody
  • Antibody evolution immunogens
    Patent number: 10849970
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 1, 2020
    Assignees: Duke University, Triad National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John R. Mascola
  • HIV-1 INCIDENCE BIOMARKERS
    Publication number: 20200095646
    Abstract: The invention is directed to methods, reagents and kits for detecting incident HIV-1 infection.
    Type: Application
    Filed: July 5, 2017
    Publication date: March 26, 2020
    Inventors: Georgia Tomaras, Kelly Seaton, Xiaoying Shen, Nicole Yates, Hua-xin Liao, Barton F. Haynes, Nathan Vandergrift, Wes Rountree, John Bainbridge
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 10588960
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 17, 2020
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • Method of inducing the production of protective anti-HIV-1 antibodies
    Patent number: 10561725
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: February 18, 2020
    Assignees: DUKE UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Barton F. Haynes, Hua-Xin Liao, Li-Hua Ping, Ronald Swanstrom, Beatrice H. Hahn, George M. Shaw
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20200002383
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 1, 2017
    Publication date: January 2, 2020
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies)
    Patent number: 10450368
    Abstract: The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding site (CD4bs) of HIV-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies of the invention or fragments thereof or any combination thereof. In certain aspects the invention provides methods to treat or prevent HIV-1 infection in a subject comprising administering to the subject a pharmaceutical composition comprising any one of the inventive antibodies or fragments thereof.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: October 22, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Hua-Xin Liao, Mattia Bonsignori
  • INHIBITORS OF COMPLEMENT FACTOR H
    Publication number: 20190315842
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Application
    Filed: November 20, 2018
    Publication date: October 17, 2019
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody