Patents by Inventor Huafang Lai

Huafang Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PLANT-PRODUCED mABs AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY
    Publication number: 20220298211
    Abstract: Disclosed are monoclonal antibodies against Chikungunya virus having enhanced effector function and efficacy, methods of producing them, and methods of treatment of Chikungunya viral infection using the antibodies.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 22, 2022
    Inventors: Qiang Chen, Jonathan Hurtado, Haiyan Sun, Huafang Lai
  • Reducing the toxicity of agrobacterium endotoxin
    Patent number: 11130956
    Abstract: The present invention relates to the fields of genetically modified Agrobacterium strains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modified Agrobacterium strains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologies. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: September 28, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang Chen, Ming Yang, Huafang Lai
  • Vaccines against Zika virus based on Zika structure proteins
    Patent number: 11078491
    Abstract: Compositions including a virus-like particle (VLP)-based vaccine displaying a portion of ZIKV envelope protein (E) domain III (DIII) and a portion of ZIKV envelope protein (E) and related methods are disclosed herein. Further, compositions including vaccines comprising a portion of ZIKA virus E protein, wherein the portion of ZIKA virus E protein is either a full-length version of ZIKA virus E protein or a functionally equivalent version of the full-length ZIKA virus E protein, are disclosed.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: August 3, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang Chen, Haiyan Sun, Huafang Lai, Ming Yang
  • Plant-derived antibodies and derivatives that reduce risk of antibody-dependent enhancement (ADE) of infection
    Patent number: 10982221
    Abstract: The present invention describes the plant-based production of a therapeutic anti-virus antibody.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: April 20, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang Chen, Huafang Lai, Jonathan Hurtado
  • Reducing the Toxicity of Agrobacterium Endotoxin
    Publication number: 20200190525
    Abstract: The present invention relates to the fields of genetically modified Agrobacterium strains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modified Agrobacterium strains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologics. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.
    Type: Application
    Filed: May 31, 2018
    Publication date: June 18, 2020
    Inventors: Qiang Chen, Ming Yang, Huafang Lai
  • VACCINES AGAINST ZIKA VIRUS BASED ON ZIKA STRUCTURE PROTEINS
    Publication number: 20180340181
    Abstract: Compositions including a virus-like particle (VLP)-based vaccine displaying a portion of ZIKV envelope protein (E) domain III (DIII) and a portion of ZIKV envelope protein (E) and related methods are disclosed herein. Further, compositions including vaccines comprising a portion of ZIKA virus E protein, wherein the portion of ZIKA virus E protein is either a full-length version of ZIKA virus E protein or a functionally equivalent version of the full-length ZIKA virus E protein, are disclosed.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 29, 2018
    Inventors: Qiang Chen, Haiyan Sun, Huafang Lai, Ming Yang
  • PLANT-DERIVED ANTIBODIES AND DERIVATIVES THAT REDUCE RISK OF ANTIBODY-DEPENDENT ENHANCEMENT (ADE) OF INFECTION
    Publication number: 20170275639
    Abstract: The present invention describes the plant-based production of a therapeutic anti-virus antibody.
    Type: Application
    Filed: January 27, 2015
    Publication date: September 28, 2017
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang CHEN, Huafang LAI, Jonathan HURTADO
  • Bispecific monoclonal antibody therapeutics against West Nile virus with improved CNS penetration
    Patent number: 9499608
    Abstract: The plant-based production of a therapeutic antibody against West Nile Virus is disclosed.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: November 22, 2016
    Assignee: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang Chen, Huafang Lai, Junyun He
  • BISPECIFIC MONOCLONAL ANTIBODY THERAPEUTICS AGAINST WEST NILE VIRUS WITH IMPROVED CNS PENETRATION
    Publication number: 20140112927
    Abstract: The plant-based production of a therapeutic antibody against West Nile Virus is disclosed.
    Type: Application
    Filed: June 6, 2012
    Publication date: April 24, 2014
    Applicants: Arizona State of University
    Inventors: Qiang Chen, Huafang Lai, Junyun He
  • Production of a monoclonal antibody therapeutic against west nile virus in plants
    Patent number: 8663950
    Abstract: The present invention describes the plant-based production of a therapeutic antibody against West Nile Virus.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: March 4, 2014
    Assignee: Arizona Board of Regents
    Inventors: Qiang Chen, Huafang Lai
  • Production of a Monoclonal Antibody Therapeutic Against West Nile Virus in Plants
    Publication number: 20120329994
    Abstract: The present invention describes the plant-based production of a therapeutic antibody against West Nile Virus.
    Type: Application
    Filed: January 10, 2011
    Publication date: December 27, 2012
    Inventors: Qiang Chen, Huafang Lai