Abstract: Provided is a weakly supervised pathological image tissue segmentation method based on an online noise suppression strategy, including: acquiring a hematoxylin-eosin (H&E) stained graph, processing the H&E stained graph to obtain a data set, dividing the data set, training a classification network based on a divided data set, and generating a pseudo-label; suppressing a noise existing in the pseudo-label based on the online noise suppression strategy, and training a semantic segmentation network through the pseudo-label after noise suppression and a training set corresponding to the pseudo-label to obtain a prediction result of the semantic segmentation network after the training, and taking the prediction result as a final segmentation result.