Patents by Inventor Huaigeng Xu

Huaigeng Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230062476
    Abstract: A production method for a genetically modified megakaryocyte, the method including a step of introducing a CRISPR-associated (Cas) family protein and guide RNA (gRNA) into a megakaryocyte to modify a subject gene, in which the Cas family protein and the gRNA to be introduced into the megakaryocyte in the step form a complex beforehand. This production method is useful as a technique for producing a genetically modified megakaryocyte and a modified platelet.
    Type: Application
    Filed: March 1, 2021
    Publication date: March 2, 2023
    Inventors: Yasuo HARADA, Akitsu HOTTA, Huaigeng XU, Naoshi SUGIMOTO, Koji ETO
  • Publication number: 20220017888
    Abstract: A production method of genomic DNA in which a deletion of more than 100 bases of nucleotides is introduced into a target region of the genomic DNA, the method includes a contact step of bringing a type I CRISPR associated complex for anti-viral defense (type I Cascade complex), CRISPR RNA (crRNA), and Cas3 protein into contact with the genomic DNA.
    Type: Application
    Filed: December 11, 2019
    Publication date: January 20, 2022
    Inventors: Akitsu HOTTA, Yuya OKUZAKI, Huaigeng XU, Peter David GEE, Yuto KITA, Tomoji MASHIMO, Kazuto YOSHIMI
  • Publication number: 20200407693
    Abstract: A method for producing, from a donor cell, a low-antigenic cell in which a rejection reaction is reduced in a case where the cell is allogeneically transplanted into a recipient, the method including: determining human leukocyte antigen (HLA) alleles for the donor cell and the recipient, respectively; specifying an HLA allele that is present in the donor cell but is not present in the recipient; and disrupting or modifying the specified HLA allele to obtain a cell population including a cell not expressing an HLA protein specific to the donor cell, in which the cell not expressing the HLA protein specific to the donor cell is the low-antigenic cell.
    Type: Application
    Filed: February 15, 2019
    Publication date: December 31, 2020
    Inventors: Akitsu Hotta, Huaigeng Xu, Shin Kaneko, Bo Wang