Patents by Inventor HUAIYU GU

HUAIYU GU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active peptide for inhibiting AMPA receptor and preparation method and use thereof
    Patent number: 10800810
    Abstract: Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises the following steps: 1) soaking a salmon skin and crushing, adding water and beating, and then adjusting pH to 6.5-7.5; 2) subjecting to a first enzymolysis using a neutral protease; 3) subjecting to a second enzymolysis using papain enzyme and then inactivating enzyme; and 4) centrifuging the enzymatic hydrolysate, and then subjecting the centrifuged supernatant to membrane filtration, concentration and decoloration, to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has good solubility, can selectively inhibit neuronal synaptic transmission caused by an AMPA receptor, and has a significant antiepileptic effect.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: October 13, 2020
    Assignee: CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES
    Inventors: Muyi Cai, Huaiyu Gu, Jun Lu, Xingchang Pan, Yong Ma, Liang Chen
  • ACTIVE PEPTIDE FOR INHIBITING AMPA RECEPTOR AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20180094028
    Abstract: Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises the following steps: 1) soaking a salmon skin and crushing, adding water and beating, and then adjusting pH to 6.5-7.5; 2) subjecting to a first enzymolysis using a neutral protease; 3) subjecting to a second enzymolysis using papain enzyme and then inactivating enzyme; and 4) centrifuging the enzymatic hydrolysate, and then subjecting the centrifuged supernatant to membrane filtration, concentration and decoloration, to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has good solubility, can selectively inhibit neuronal synaptic transmission caused by an AMPA receptor, and has a significant antiepileptic effect.
    Type: Application
    Filed: December 6, 2017
    Publication date: April 5, 2018
    Inventors: MUYI CAI, HUAIYU GU, JUN LU, XINGCHANG PAN, YONG MA, LIANG CHEN