Patents by Inventor Huaizhong Pan

Huaizhong Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric drug delivery conjugates and methods of making and using thereof
    Patent number: 9289510
    Abstract: Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: March 22, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Huaizhong Pan, Jiyuan Yang, Pavla Kopeckova, Kui Luo, Jindrich Kopecek
  • CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
    Publication number: 20140212357
    Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
    Type: Application
    Filed: April 2, 2014
    Publication date: July 31, 2014
    Applicants: University of Utah Research Foundation, Ramot at Tel-Aviv University Ltd.
    Inventors: RONIT SATCHI-FAINARO, EHUD SEGAL, JINDRICH KOPECEK, PAVLA KOPECKOVA, HUAIZHONG PAN
  • Conjugate of a polymer, an anti-angiogenesis agent and a targeting moiety, and uses thereof in the treatment of bone related angiogenesis conditions
    Patent number: 8703114
    Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: April 22, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., University of Utah Research Foundation
    Inventors: Ronit Satchi-Fainaro, Ehud Segal, Jindrich Kopecek, Pavla Kopeckova, Huaizhong Pan
  • POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20130156722
    Abstract: Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 20, 2013
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Pavla Kopecková, Huaizhong Pan, Jiyuan Yang, Jindrich Kopecek, Kui Luo
  • CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
    Publication number: 20110085979
    Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
    Type: Application
    Filed: May 21, 2009
    Publication date: April 14, 2011
    Applicants: Ramot at Tel-Aviv University Ltd., University of Utah Research Foundation
    Inventors: Ronit Satchi-Fainaro, Ehud Segal, Jindrich Kopecek, Pavla Kopeckova, Huaizhong Pan