Abstract: The present disclosure relates to a method for determining oil and gas relative permeabilities of a reservoir. The method includes: drilling a cylindrical core from a to-be-tested reservoir; injecting an oil and gas mixture into the cylindrical core through the piston container at a set flow rate by using the relative permeability testing device, and reducing pressures at a control end of the back pressure valve in sequence to obtain experimental values acquired under each pressure at the control end of the back pressure valve; equivalently simulating developing performance of a producing well of the to-be-tested reservoir using a one-dimensional numerical simulation grid model based on current oil and gas phase relative permeability curves, so as to obtain simulation values at different times; constructing an objective function according to the experimental and simulation values; determining whether a value of the objective function reaches a preset target value.

Abstract: The present invention discloses a protein transformation method based on an amino acid knowledge graph and active learning, including: building an amino acid knowledge graph based on biochemical attributes of amino acids; enhancing protein data in combination with the amino acid knowledge graph to obtain enhanced protein data, and performing representation learning to obtain first enhanced protein representations; performing representation learning on the protein data or the protein data and the amino acid knowledge graph by using a pre-trained protein model to obtain second enhanced protein representations; synthesizing the first enhanced protein representations and the second enhanced protein representations to obtain enhanced protein representations; taking the enhanced protein representations as samples, and through active learning, screening out representative samples from the samples, manually annotating protein properties, and training a protein property prediction model by using the manually annotated

Abstract: The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.

Abstract: The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.

Abstract: Methods, systems, and computer-readable storage media are disclosed that facilitate flow design for multimodal communication applications. Aspects for selecting, generating, and/or arranging application modules are described which include providing a graphical user interface (GUI) and receiving a user input via the GUI. The application modules are interchangeable within an interchangeable sequence of application modules based on the user input. The interchangeable sequence includes a first application module configured to receive data via a first communication channel, and a second application module configured to receive data via a second communication channel disparate from the first communication channel.

Abstract: Methods, apparatuses, and computer program products are disclosed that facilitate providing and managing location-based interactive campaigns. With respect to facilitating providing location-based interactive campaigns, a geographic location is defined within a virtual fence, and associated with an interactive campaign. Location data identifying a current location of a wireless device is then received and processed to determine whether to include or exclude the wireless device from participating in the interactive campaign based on the current location relative to the defined geographic location. With respect to facilitating the management of location-based interactive campaigns, a configurable campaign profile is stored and configured according to a first configuration. The configurable campaign profile is then reconfigured according to a second configuration in response to receiving an input associated with the configurable campaign profile.

Abstract: Electronic and automatic gifting techniques are provided for messages, such as short message service (SMS) or multimedia messaging service (MMS) messages, wherein a gifter designates a recipient for one or more gift(s) offered in a set of gifts. Based on a selection of gift(s), message(s) are automatically generated for the gift(s) having unique identifier(s) that correspond to products or services of an enabling entity that enables the products or services. The message(s) including the unique identifier(s) are then automatically transmitted to the recipient. The unique identifier(s) can be encrypted/hashed with a secret provided by the recipient for an additional layer of security. Any of gifter information, giftee information, context of the service, or external information, such as global positioning service (GPS) location, can be used to make recommendations for gifts in the set of gifts.

Abstract: User information is displayed as a multi-sided user object for different sides of the multi-sided user object on a device having a limited display. The user object can be a user profile and the multi-sided user object can be a multi-sided user profile object where updates to the user profile can be made directly via a PC, or via the device via changes made to side(s) of the multi-sided user profile object. The multi-sided user object can be displayed as part of any client process, e.g., an application, a networked service or web widget display system.