Abstract: A method for synthesizing nature-identical raspberry ketone is provided, belonging to the technical field of pharmaceutical synthesis. The nature-identical raspberry ketone is obtained by using natural p-anisaldehyde and natural acetone as initial raw materials to allow three-step continuous reactions of basic resin-catalyzed Claisen-Schmidt condensation, enzyme-catalyzed reduction, and demethylation of sodium ethanethiolate. The synthesis method is safe and clean, and has a stable yield reaching approximately 85%, providing a basis for industrial continuous production. The synthesis method not only meets the requirements for clean production, but also saves labor costs by virtue of the continuous process, and is suitable for large-scale industrial production.